7099. A comparison of sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary renal cell carcinoma: a randomised, open-label, phase 2 trial.
作者: Sumanta K Pal.;Catherine Tangen.;Ian M Thompson.;Naomi Balzer-Haas.;Daniel J George.;Daniel Y C Heng.;Brian Shuch.;Mark Stein.;Maria Tretiakova.;Peter Humphrey.;Adebowale Adeniran.;Vivek Narayan.;Georg A Bjarnason.;Ulka Vaishampayan.;Ajjai Alva.;Tian Zhang.;Scott Cole.;Melissa Plets.;John Wright.;Primo N Lara.
来源: Lancet. 2021年397卷10275期695-703页
MET (also known as hepatocyte growth factor receptor) signalling is a key driver of papillary renal cell carcinoma (PRCC). Given that no optimal therapy for metastatic PRCC exists, we aimed to compare an existing standard of care, sunitinib, with the MET kinase inhibitors cabozantinib, crizotinib, and savolitinib for treatment of patients with PRCC.
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