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7021. Clinical Utility of Obtaining Endoscopic Ultrasound-Guided Fine-Needle Biopsies for Histologic Analyses of Pancreatic Cystic Lesions.
作者: Jennifer Phan.;David Dawson.;Alireza Sedarat.;M Phillip Fejleh.;Neil Marya.;Adarsh M Thaker.;Melinda Rogers.;Stephen Kim.;V Raman Muthusamy.
来源: Gastroenterology. 2020年158卷3期475-477.e1页 7024. Prostaglandin E2 Induces miR675-5p to Promote Colorectal Tumor Metastasis via Modulation of p53 Expression.
作者: Bo Cen.;Jessica D Lang.;Yuchen Du.;Jie Wei.;Ying Xiong.;Norma Bradley.;Dingzhi Wang.;Raymond N DuBois.
来源: Gastroenterology. 2020年158卷4期971-984.e10页
Prostaglandin E2 (PGE2) promotes colorectal tumor formation and progression by unknown mechanisms. We sought to identify microRNAs (miRNAs) that might mediate the effects of PGE2 on colorectal cancer (CRC) development.
7026. Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis.
作者: Andreana N Holowatyj.;Biljana Gigic.;Esther Herpel.;Augustin Scalbert.;Martin Schneider.;Cornelia M Ulrich.; .; .
来源: Gastroenterology. 2020年158卷4期1155-1158.e2页 7029. AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
作者: Prateek Sharma.;Nicholas J Shaheen.;David Katzka.;Jacques J G H M Bergman.
来源: Gastroenterology. 2020年158卷3期760-769页
The purpose of this best practice advice article is to describe the role of Barrett's endoscopic therapy (BET) in patients with Barrett's esophagus (BE) with dysplasia and/or early cancer and appropriate follow-up of these patients.
7031. Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells.
作者: Dipankar Ray.;Paramita Ray.;Daysha Ferrer-Torres.;Zhuwen Wang.;Derek Nancarrow.;Hee-Won Yoon.;May San Martinho.;Tonaye Hinton.;Scott Owens.;Dafydd Thomas.;Hui Jiang.;Theodore S Lawrence.;Jules Lin.;Kiran Lagisetty.;Andrew C Chang.;David G Beer.
来源: Gastroenterology. 2020年158卷3期583-597.e1页
Barrett's esophagus (BE) can progress to dysplasia and esophageal adenocarcinoma (EAC), accompanied by mutations in TP53 that increase the stability of its product, p53. We analyzed BE tissues for messenger RNAs (mRNAs) that associate with BE progression and identified one that affects the stabilization of p53.
7032. Development and Validation of a Test to Monitor Endoscopic Activity in Patients With Crohn's Disease Based on Serum Levels of Proteins.
作者: Geert D'Haens.;Orlaith Kelly.;Robert Battat.;Mark S Silverberg.;David Laharie.;Edouard Louis.;Edoardo Savarino.;Giorgia Bodini.;Andres Yarur.;Brigid S Boland.;Waqqas Afif.;Xiao-Jun Li.;Michael Hale.;Jessica Ho.;Venkateswarlu Kondragunta.;Benjamin Huang.;Crystal Kuy.;Lauren Okada.;Kelly D Hester.;Kurtis R Bray.;Larry Mimms.;Anjali Jain.;Siddharth Singh.;Angelina Collins.;Mark A Valasek.;William J Sandborn.;Severine Vermeire.;Parambir S Dulai.
来源: Gastroenterology. 2020年158卷3期515-526.e10页
Noninvasive tests to measure endoscopic activity in patients with Crohn's disease (CD) have limitations. We aimed to develop a test to identify patients in remission, based on endoscopic analysis, and monitor CD activity based on serum levels of proteins.
7033. ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells.
作者: Mingyang Liu.;Yuqing Zhang.;Jingxuan Yang.;Xiaobo Cui.;Zhijun Zhou.;Hanxiang Zhan.;Kai Ding.;Xiang Tian.;Zhibo Yang.;Kar-Ming A Fung.;Barish H Edil.;Russell G Postier.;Michael S Bronze.;Martin E Fernandez-Zapico.;Marc P Stemmler.;Thomas Brabletz.;Yi-Ping Li.;Courtney W Houchen.;Min Li.
来源: Gastroenterology. 2020年158卷3期679-692.e1页
Pancreatic tumors undergo rapid growth and progression, become resistant to chemotherapy, and recur after surgery. We studied the functions of the solute carrier family 39 member 4 (SLC39A4, also called ZIP4), which regulates concentrations of intracellular zinc and is increased in pancreatic cancer cells, in cell lines and mice.
7034. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa.
作者: Jasper B J Kamphuis.;Bruno Guiard.;Mathilde Leveque.;Maiwenn Olier.;Isabelle Jouanin.;Sophie Yvon.;Valerie Tondereau.;Pauline Rivière.;Françoise Guéraud.;Sylvie Chevolleau.;Maria-Helena Noguer-Meireles.;Jean-François Martin.;Laurent Debrauwer.;Helene Eutamène.;Vassilia Theodorou.
来源: Gastroenterology. 2020年158卷3期652-663.e6页
Irritable bowel syndrome (IBS) is characterized by abdominal pain, bloating, and erratic bowel habits. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) can reduce symptoms of IBS, possibly by reducing microbial fermentation products. We investigated whether ingestion of FODMAPs can induce IBS-like visceral hypersensitivity mediated by fermentation products of intestinal microbes in mice.
7035. Use of Treatments for Irritable Bowel Syndrome and Patient Satisfaction Based on the IBS in America Survey.
作者: Vikram Rangan.;Sarah Ballou.;Andrea Shin.;Michael Camilleri.; .;Anthony Lembo.
来源: Gastroenterology. 2020年158卷3期786-788.e1页
Many treatments for irritable bowel syndrome are available to those with the disease. Satisfaction with these treatments is low, and a need exists for further effective treatments for the condition.
7036. Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
作者: William J Sandborn.;Laurent Peyrin-Biroulet.;Jinkun Zhang.;Michael Chiorean.;Séverine Vermeire.;Scott D Lee.;Tanja Kühbacher.;Bruce Yacyshyn.;Christopher H Cabell.;Snehal U Naik.;Preston Klassen.;Julián Panés.
来源: Gastroenterology. 2020年158卷3期550-561页
Etrasimod (APD334) is an oral, selective sphingosine 1-phosphate receptor modulator in development for immune-mediated inflammatory disorders. We assessed the efficacy and safety of etrasimod in patients with moderately to severely active ulcerative colitis (UC).
7037. Circulating Tumor DNA Analysis for Detection of Minimal Residual Disease After Chemoradiotherapy for Localized Esophageal Cancer.
作者: Tej D Azad.;Aadel A Chaudhuri.;Penny Fang.;Yawei Qiao.;Mohammad S Esfahani.;Jacob J Chabon.;Emily G Hamilton.;Yi D Yang.;Alex Lovejoy.;Aaron M Newman.;David M Kurtz.;Michael Jin.;Joseph Schroers-Martin.;Henning Stehr.;Chih Long Liu.;Angela Bik-Yu Hui.;Viren Patel.;Dipen Maru.;Steven H Lin.;Ash A Alizadeh.;Maximilian Diehn.
来源: Gastroenterology. 2020年158卷3期494-505.e6页
Biomarkers are needed to risk stratify after chemoradiotherapy for localized esophageal cancer. These could improve identification of patients at risk for cancer progression and selection of additional therapy.
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