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7001. Clinical value of amyloid-beta1-40 as a marker of thrombo-inflammation in antiphospholipid syndrome.
作者: Maria G Tektonidou.;Evrydiki Kravvariti.;Nikolaos I Vlachogiannis.;Georgios Georgiopoulos.;Aimilia Mantzou.;Petros P Sfikakis.;Konstantinos Stellos.;Kimon Stamatelopoulos.
来源: Rheumatology (Oxford). 2021年60卷4期1669-1675页
Amyloid-beta1-40 (Aβ40) is a pro-inflammatory peptide under investigation as a novel biomarker of vascular inflammation, endothelial dysfunction and atherothrombosis in the general population. Herein we tested the hypothesis that Aβ40 is deregulated in APS, a systemic autoimmune disease characterized by a thrombo-inflammatory state.
7002. Corrigendum to: Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register.
作者: Katie Bechman.;Anuoluwapo Oke.;Mark Yates.;Sam Norton.;Elaine Dennison.;Andrew P Cope.;James B Galloway.
来源: Rheumatology (Oxford). 2021年60卷4期2033页 7003. Skewed peripheral B- and T-cell compartments in patients with ANCA-associated vasculitis.
作者: Jonathan London.;Nicolas Dumoitier.;Sébastien Lofek.;Jérémie Dion.;Benjamin Chaigne.;Julie Mocek.;Nathalie Thieblemont.;Pascal Cohen.;Claire Le Jeunne.;Loïc Guillevin.;Véronique Witko-Sarsat.;Nadine Varin-Blank.;Benjamin Terrier.;Luc Mouthon.; .
来源: Rheumatology (Oxford). 2021年60卷5期2157-2168页
To characterize lymphocytes dysregulation in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).
7004. Neutrophil subpopulations and their activation potential in patients with antiphospholipid syndrome and healthy individuals.
作者: Lisa-Marie Mauracher.;Moritz Krall.;Johanna Roiß.;Lena Hell.;Silvia Koder.;Thomas M Hofbauer.;Johanna Gebhart.;Hubert Hayden.;Christine Brostjan.;Cihan Ay.;Ingrid Pabinger.
来源: Rheumatology (Oxford). 2021年60卷4期1687-1699页
Patients with APS are at increased risk of thromboembolism. Neutrophils have been shown to play a role in inducing thrombosis. We aimed to investigate differences in neutrophil subpopulations, their potential of activation and neutrophil extracellular trap (NET) formation comparing high and low-density neutrophils (HDNs/LDNs) as well as subpopulations in patients with APS and controls to gain deeper insight into their potential role in thrombotic manifestations in patients with APS.
7005. Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies.
作者: Didem Saygin.;Chester V Oddis.;Siamak Moghadam-Kia.;Bonny Rockette-Wagner.;Nicole Neiman.;Diane Koontz.;Rohit Aggarwal.
来源: Rheumatology (Oxford). 2021年60卷5期2146-2156页
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis.
7006. Successful management with Janus kinase inhibitor tofacitinib in refractory juvenile dermatomyositis: a pilot study and literature review.
作者: Zhongxun Yu.;Lin Wang.;Meiying Quan.;Tiannan Zhang.;Hongmei Song.
来源: Rheumatology (Oxford). 2021年60卷4期1700-1707页
JDM is a rare autoimmune inflammatory muscle disease with a pronounced IFN signature. Treatment for children with JDM has improved over the years with the use of steroids and immunosuppressive agents. However, there remains a subset of children who have refractory disease. Janus kinase and type I IFN signalling production are suspected to contribute to the pathogenesis of JDM. Our pilot study investigated the use of tofacitinib, a Janus kinase inhibitor, in refractory JDM cases to provide new therapeutic options for better treatment.
7007. A randomized prospective open-label controlled trial comparing the performance of a connected monitoring interface versus physical routine monitoring in patients with rheumatoid arthritis.
作者: Yves-Marie Pers.;Verushka Valsecchi.;Thibault Mura.;Safa Aouinti.;Nathalie Filippi.;Sarah Marouen.;Hind Letaief.;Pierre Le Blay.;Michel Autuori.;Dominique Fournet.;Grégoire Mercier.;Rosanna Ferreira.;Christian Jorgensen.
来源: Rheumatology (Oxford). 2021年60卷4期1659-1668页
In RA, telemedicine may allow tight control of disease activity while reducing hospital visits. We developed a smartphone application connected with a physician's interface to monitor RA patients. We aimed to assess the performance of this e-Health solution in comparison with routine practice in the management of patients with RA.
7008. The impact of COVID-19 on rheumatology practice across Africa.
作者: Richard O Akintayo.;Akpabio A Akpabio.;Asgar A Kalla.;Dzifa Dey.;Angela N Migowa.;Hakeem Olaosebikan.;Rachid Bahiri.;Yasser El Miedany.;Djohra Hadef.;Wafa Hamdi.;Omondi Oyoo.;Samy Slimani.;Abubakar Yerima.;Yassmin Taha.;Adewale O Adebajo.;Olufemi O Adelowo.;Mohammed Tikly.;Imad Ghozlani.;Kawther Ben Abdelghani.;Nermeen A Fouad.;Doaa Mosad.;Dalia El Mikkawy.;Mohamed Hassan Abu-Zaid.;Rasha A Abdel-Magied.
来源: Rheumatology (Oxford). 2021年60卷1期392-398页
To identify the changes in rheumatology service delivery across the five regions of Africa from the impact of the COVID-19 pandemic.
7009. Otological aspects of NLRP3-related autoinflammatory disorder focusing on the responsiveness to anakinra.
作者: Bong Jik Kim.;Young Ho Kim.;Seungmin Lee.;Jin Hee Han.;Sang-Yeon Lee.;Jeon Seong.;Dong-Han Lee.;Bonggi Kim.;Hye-Rim Park.;Marge Carandang.;Dooyi Oh.;Seung Ha Oh.;Joong Gon Kim.;Soyoung Lee.;Byung Yoon Choi.
来源: Rheumatology (Oxford). 2021年60卷3期1523-1532页
Gradually progressive sensorineural hearing loss (SNHL) is a prevalent sensory defect. It is generally untreatable, making rehabilitation by hearing aid or cochlear implantation the only option. However, SNHL as one of the symptoms of the hereditary autoinflammatory systemic disease cryopyrin-associated periodic syndrome, or as the only symptom of the cochlea-specific form (DFNA34), was suggested to respond to IL-1 antagonist (anakinra) therapy, which ameliorates NLRP3 variants-induced over-secretion of IL-1β. We analysed genotypic and phenotypic spectrum of cryopyrin-associated periodic syndrome or DFNA34, specifically focusing on the responsiveness of SNHL to anakinra.
7010. Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study.
作者: Jose Luis Rodriguez-Garcia.;Gines Sanchez-Nievas.;Juan Arevalo-Serrano.;Cristina Garcia-Gomez.;Jose Maria Jimenez-Vizuete.;Elisa Martinez-Alfaro.
来源: Rheumatology (Oxford). 2021年60卷1期399-407页
The Janus kinase (JAK) inhibitor baricitinib may block viral entry into pneumocytes and prevent cytokine storm in patients with SARS-CoV-2 pneumonia. We aimed to assess whether baricitinib improved pulmonary function in patients treated with high-dose corticosteroids for moderate to severe SARS-CoV-2 pneumonia.
7011. Comment on: 'It can't be zero!' difficulties in completing patient global assessment in rheumatoid arthritis: a mixed methods study: reply.
作者: Ricardo J O Ferreira.;Maarten de Wit.;Cátia Duarte.;José A P da Silva.;Mwidimi Ndosi.
来源: Rheumatology (Oxford). 2021年60卷1期e30-e31页 7012. Comment on: 'It can't be zero!' Difficulties in completing patient global assessment in rheumatoid arthritis: a mixed methods study.
作者: Theodore Pincus.;Kathryn A Gibson.;Yusuf Yazici.;Martin Bergman.;Juan Schmukler.;Joel A Block.
来源: Rheumatology (Oxford). 2021年60卷1期e28-e29页 7013. Construct validity of the ASAS health index in psoriatic arthritis: a cross-sectional analysis.
作者: Isla Morante.;Elena Aurrecoechea.;Ignacio Villa.;Montserrat Santos.;Leyre Riancho.;Rubén Queiro.
来源: Rheumatology (Oxford). 2021年60卷3期1465-1473页
The Assessment of SpondyloArthritis international Society health index (ASAS-HI) was designed to assess the global health of patients with spondyloarthritis, but its performance in psoriatic arthritis (PsA) is hardly known. We addressed the clinimetric properties of this instrument in patients with PsA.
7014. Acquired low immunoglobulin levels and risk of clinically relevant infection in adult patients with systemic lupus erythematosus: a cohort study.
作者: Ibrahim Almaghlouth.;Jiandong Su.;Sindhu R Johnson.;Eleanor Pullenayegum.;Dafna Gladman.;Murray Urowitz.
来源: Rheumatology (Oxford). 2021年60卷3期1456-1464页
Infection is a leading cause of death in the SLE population. Low immunoglobulin levels might be a potential risk for infection. We aimed to assess whether acquired low levels of any type of immunoglobulin increase the risk of clinically relevant infection in adult patients with SLE.
7015. Interferon activation status underlies higher antibody response to viral antigens in patients with systemic lupus erythematosus receiving no or light treatment.
作者: Albin Björk.;Rui Da Silva Rodrigues.;Elina Richardsdotter Andersson.;Jorge I Ramírez Sepúlveda.;Johannes Mofors.;Marika Kvarnström.;Vilija Oke.;Elisabet Svenungsson.;Iva Gunnarsson.;Marie Wahren-Herlenius.
来源: Rheumatology (Oxford). 2021年60卷3期1445-1455页
Infections have been proposed as an environmental risk factor for autoimmune disease. Responses to microbial antigens may be studied in vivo during vaccination. We therefore followed patients with SLE and controls during split-virion influenza vaccination to quantify antibody responses against viral antigens and associated cellular and proteome parameters.
7016. Sustained-release diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate) for knee osteoarthritis: a randomized phase 2 study.
作者: Yoshihiro Nishida.;Kazuyuki Kano.;Yuji Nobuoka.;Takayuki Seo.
来源: Rheumatology (Oxford). 2021年60卷3期1435-1444页
To evaluate the efficacy and safety of diclofenac etalhyaluronate (DF-HA) (ONO-5704/SI-613), a novel DF-conjugated hyaluronate, in patients with knee OA in Japan.
7017. Systemic vascular distensibility relates to exercise capacity in connective tissue disease.
作者: Inderjit Singh.;Rudolf K F Oliveira.;Robert Naeije.;William M Oldham.;Mariana Faria-Urbina.;Aaron B Waxman.;David M Systrom.
来源: Rheumatology (Oxford). 2021年60卷3期1429-1434页
Exercise intolerance is a common clinical manifestation of CTD. Frequently, CTD patients have associated cardio-pulmonary disease, including pulmonary hypertension or heart failure that impairs aerobic exercise capacity (pVO2). The contribution of the systemic micro-vasculature to reduced exercise capacity in CTD patients without cardiopulmonary disease has not been fully described. In this study, we sought to examine the role of systemic vascular distensibility, α in reducing exercise capacity (i.e. pVO2) in CTD patients.
7018. Genetic diversity of Staphylococcus aureus influences disease phenotype of systemic lupus erythematosus.
作者: Fulvia Ceccarelli.;Alessandra Lo Presti.;Giulio Olivieri.;Silvia Angeletti.;Carlo Perricone.;Cristina Garufi.;Giancarlo Iaiani.;Lucia De Florio.;Francesca Antonelli.;Marina De Cesaris.;Alessandra Giordano.;Luigino Amori.;Francesca Romana Spinelli.;Cristiano Alessandri.;Guido Valesini.;Massimo Ciccozzi.;Fabrizio Conti.
来源: Rheumatology (Oxford). 2021年60卷2期958-966页
We investigated the genetic diversity, molecular epidemiology and evolutionary dynamics of Staphylococcus aureus (SA) isolated from SLE patients by means of phylogenetic analysis.
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