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7002. Intravenous Bevacizumab Reduces Transfusion Requirements and Endoscopic Interventions in Patients With Gastric Antral Vascular Ectasia and Small Bowel Angioectasia.
作者: Hasan Ahmad Hasan Albitar.;Yahya Almodallal.;Konstantinos A Papadakis.;Elizabeth Rajan.;Patrick S Kamath.;Vivek N Iyer.
来源: Gastroenterology. 2020年158卷4期1162-1163.e4页 7003. A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice.
作者: Adam M Zahm.;Amber W Wang.;Yue J Wang.;Jonathan Schug.;Kirk J Wangensteen.;Klaus H Kaestner.
来源: Gastroenterology. 2020年158卷4期1044-1057.e17页
Liver regeneration is impaired in mice with hepatocyte-specific deficiencies in microRNA (miRNA) processing, but it is not clear which miRNAs regulate this process. We developed a high-throughput screen to identify miRNAs that regulate hepatocyte repopulation after toxic liver injury using fumarylacetoacetate hydrolase-deficient mice.
7004. Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice.
Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic trypsinogen, can accelerate its autoactivation and cause hereditary or sporadic chronic pancreatitis. Disruption of the locus that encodes cationic trypsinogen in mice (T7) causes loss of expression of the protein, but only partially decreases the severity of secretagogue-induced acute pancreatitis and has no effect on chronic pancreatitis. We investigated whether trypsinogen becomes pathogenic only when its activation is promoted by mutation.
7008. Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.
作者: Sasha Jardine.;Sierra Anderson.;Stephen Babcock.;Gabriella Leung.;Jie Pan.;Neel Dhingani.;Neil Warner.;Conghui Guo.;Iram Siddiqui.;Daniel Kotlarz.;James J Dowling.;Roman A Melnyk.;Scott B Snapper.;Christoph Klein.;Jay R Thiagarajah.;Aleixo M Muise.
来源: Gastroenterology. 2020年158卷4期1000-1015页
Mutations in the tetratricopeptide repeat domain 7A gene (TTC7A) cause intestinal epithelial and immune defects. Patients can become immune deficient and develop apoptotic enterocolitis, multiple intestinal atresia, and recurrent intestinal stenosis. The intestinal disease in patients with TTC7A deficiency is severe and untreatable, and it recurs despite resection or allogeneic hematopoietic stem cell transplant. We screened drugs for those that prevent apoptosis of in cells with TTC7A deficiency and tested their effects in an animal model of the disease.
7016. Routine Prophylactic Clip Closure Is Cost Saving After Endoscopic Resection of Large Colon Polyps in a Medicare Population.
作者: Eric D Shah.;Heiko Pohl.;Douglas K Rex.;Shannon J Morales.;Linda A Feagins.;Ryan Law.
来源: Gastroenterology. 2020年158卷4期1164-1166.e3页 |