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6961. Composite Metric for Benchmarking Site Performance in Transcatheter Aortic Valve Replacement: Results From the STS/ACC TVT Registry.
作者: Nimesh D Desai.;Sean M O'Brien.;David J Cohen.;John Carroll.;Sreekanth Vemulapalli.;Suzanne V Arnold.;John K Forrest.;Vinod H Thourani.;Ajay J Kirtane.;Brian O'Neil.;Pratik Manandhar.;David M Shahian.;Vinay Badhwar.;Joseph E Bavaria.
来源: Circulation. 2021年144卷3期186-194页
Transcatheter aortic valve replacement (TAVR) is a transformative therapy for aortic stenosis. Despite rapid improvements in technology and techniques, serious complications remain relatively common and are not well described by single outcome measures. The purpose of this study was to determine whether there is site-level variation in TAVR outcomes in the United States using a novel 30-day composite measure.
6962. Framework to Classify Reverse Cardiac Remodeling With Mechanical Circulatory Support: The Utah-Inova Stages.
作者: Palak Shah.;Mitchell Psotka.;Iosif Taleb.;Rami Alharethi.;Mortada A Shams.;Omar Wever-Pinzon.;Michael Yin.;Federica Latta.;Josef Stehlik.;James C Fang.;Guoqing Diao.;Ramesh Singh.;Naila Ijaz.;Christos P Kyriakopoulos.;Wei Zhu.;Christopher W May.;Lauren B Cooper.;Shashank S Desai.;Craig H Selzman.;Abdallah G Kfoury.;Stavros G Drakos.
来源: Circ Heart Fail. 2021年14卷5期e007991页
Variable definitions and an incomplete understanding of the gradient of reverse cardiac remodeling following continuous flow left ventricular assist device (LVAD) implantation has limited the field of myocardial plasticity. We evaluated the continuum of LV remodeling by serial echocardiographic imaging to define 3 stages of reverse cardiac remodeling following LVAD.
6965. Response by Waldmann et al to Letter Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry".
作者: Victor Waldmann.;Nicolas Combes.;Kumar Narayanan.;Eloi Marijon.
来源: Circulation. 2021年143卷18期e900-e901页 6966. Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism: A Multinational Prospective Real-Life Study (the RELAX-PE Study).
作者: Helia Robert-Ebadi.;Philippe Robin.;Olivier Hugli.;Franck Verschuren.;Albert Trinh-Duc.;Pierre-Marie Roy.;Jeannot Schmidt.;Thierry Fumeaux.;Guy Meyer.;Daniel Hayoz.;Pierre-Nicolas Carron.;Pierre-Yves Salaun.;François Sarasin.;Olivier Rutschmann.;Grégoire Le Gal.;Marc Righini.
来源: Circulation. 2021年143卷18期1828-1830页 6969. Letter by Ferrero and Chessa Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry".6971. Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.
作者: Dries A M Feyen.;Isaac Perea-Gil.;Renee G C Maas.;Magdalena Harakalova.;Alexandra A Gavidia.;Jennifer Arthur Ataam.;Ting-Hsuan Wu.;Aryan Vink.;Jiayi Pei.;Nirmal Vadgama.;Albert J Suurmeijer.;Wouter P Te Rijdt.;Michelle Vu.;Prashila L Amatya.;Maricela Prado.;Yuan Zhang.;Logan Dunkenberger.;Joost P G Sluijter.;Karim Sallam.;Folkert W Asselbergs.;Mark Mercola.;Ioannis Karakikes.
来源: Circulation. 2021年144卷5期382-392页
Phospholamban (PLN) is a critical regulator of calcium cycling and contractility in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy with a high prevalence of ventricular arrhythmias. How the R14 deletion causes dilated cardiomyopathy is poorly understood, and there are no disease-specific therapies.
6972. Provider Care Team Segregation and Operative Mortality Following Coronary Artery Bypass Grafting.
作者: John M Hollingsworth.;Xianshi Yu.;Phyllis L Yan.;Hyesun Yoo.;Dana A Telem.;Ekow N Yankah.;Ji Zhu.;Akbar K Waljee.;Brahmajee K Nallamothu.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷5期e007778页
Studies have shown that Black patients die more frequently following coronary artery bypass grafting than their White counterparts for reasons not fully explained by disease severity or comorbidity. To examine whether provider care team segregation within hospitals contributes to this inequity, we analyzed national Medicare data.
6973. Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Dual antiplatelet treatment (DAPT) with aspirin plus clopidogrel for a limited time is recommended after minor noncardioembolic stroke.
6974. Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 to 2016.
作者: Maxwell Birger.;Alexander S Kaldjian.;Gregory A Roth.;Andrew E Moran.;Joseph L Dieleman.;Brandon K Bellows.
来源: Circulation. 2021年144卷4期271-282页
Spending on cardiovascular disease and cardiovascular risk factors (cardiovascular spending) accounts for a significant portion of overall US health care spending. Our objective was to describe US adult cardiovascular spending patterns in 2016, changes from 1996 to 2016, and factors associated with changes over time.
6975. Hemodynamic Benefits From Left Atrial Pacing to Treat Interatrial Conduction Delay Following Atrial Fibrillation Ablation.
作者: Madeline K Mahowald.;Yogesh N V Reddy.;Juan A Crestanello.;Samuel J Asirvatham.;Rick A Nishimura.
来源: Circ Heart Fail. 2021年14卷5期e008191页 6976. Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial.
作者: Tania A Pawade.;Mhairi K Doris.;Rong Bing.;Audrey C White.;Laura Forsyth.;Emily Evans.;Catriona Graham.;Michelle C Williams.;Edwin J R van Beek.;Alison Fletcher.;Philip D Adamson.;Jack P M Andrews.;Timothy R G Cartlidge.;William S A Jenkins.;Maaz Syed.;Takeshi Fujisawa.;Christophe Lucatelli.;William Fraser.;Stuart H Ralston.;Nicholas Boon.;Bernard Prendergast.;David E Newby.;Marc R Dweck.
来源: Circulation. 2021年143卷25期2418-2427页
Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone turnover and osteoblastic differentiation of valvular interstitial cells are important contributory mechanisms. We aimed to establish whether inhibition of these pathways with denosumab or alendronic acid could reduce disease progression in aortic stenosis.
6977. In Vivo Function of Flow-Responsive Cis-DNA Elements of eNOS Gene: A Role for Chromatin-Based Mechanisms.
作者: Kyung Ha Ku.;Michelle K Dubinsky.;Aravin N Sukumar.;Noeline Subramaniam.;Manon Y M Feasson.;Ranju Nair.;Eileen Tran.;Brent M Steer.;Britta J Knight.;Philip A Marsden.
来源: Circulation. 2021年144卷5期365-381页
eNOS (endothelial nitric oxide synthase) is an endothelial cell (EC)-specific gene predominantly expressed in medium- to large-sized arteries where ECs experience atheroprotective laminar flow with high shear stress. Disturbed flow with lower average shear stress decreases eNOS transcription, which leads to the development of atherosclerosis, especially at bifurcations and curvatures of arteries. This prototypic arterial EC gene contains 2 distinct flow-responsive cis-DNA elements in the promoter, the shear stress response element (SSRE) and the KLF (Krüppel-like factor) element. Previous in vitro studies suggested their positive regulatory functions on flow-induced transcription of EC genes including eNOS. However, the in vivo function of these cis-DNA elements remains unknown.
6978. Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction.
作者: Joyce C K Man.;Fernanda M Bosada.;Koen T Scholman.;Joost A Offerhaus.;Roddy Walsh.;Karel van Duijvenboden.;Vincent W W van Eif.;Connie R Bezzina.;Arie O Verkerk.;Bastiaan J Boukens.;Phil Barnett.;Vincent M Christoffels.
来源: Circulation. 2021年144卷3期229-242页
Genetic variants in SCN10A, encoding the neuronal voltage-gated sodium channel NaV1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate. The cardiac function of SCN10A has not been resolved, however, and diverging mechanisms have been proposed. Here, we investigated the cardiac expression of SCN10A and the function of a variant-sensitive intronic enhancer previously linked to the regulation of SCN5A, encoding the major essential cardiac sodium channel NaV1.5.
6979. Racial Disparities in In-Hospital Adverse Events Among Patients With Atrial Fibrillation Implanted With a Watchman Left Atrial Appendage Occlusion Device: A US National Perspective.
作者: Muhammad Zia Khan.;Muhammad Bilal Munir.;Douglas Darden.;Deepak Kumar Pasupula.;Sudarshan Balla.;Frederick T Han.;Ryan Reeves.;Jonathan C Hsu.
来源: Circ Arrhythm Electrophysiol. 2021年14卷5期e009691页
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6980. Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
作者: Sabrina Geisberger.;Hendrik Bartolomaeus.;Patrick Neubert.;Ralf Willebrand.;Christin Zasada.;Thomas Bartolomaeus.;Victoria McParland.;Dries Swinnen.;Anneleen Geuzens.;András Maifeld.;Luka Krampert.;Marion Vogl.;Anja Mähler.;Nicola Wilck.;Lajos Markó.;Ekin Tilic.;Sofia K Forslund.;Katrina J Binger.;Johannes Stegbauer.;Ralf Dechend.;Markus Kleinewietfeld.;Jonathan Jantsch.;Stefan Kempa.;Dominik N Müller.
来源: Circulation. 2021年144卷2期144-158页
Dietary high salt (HS) is a leading risk factor for mortality and morbidity. Serum sodium transiently increases postprandially but can also accumulate at sites of inflammation affecting differentiation and function of innate and adaptive immune cells. Here, we focus on how changes in extracellular sodium, mimicking alterations in the circulation and tissues, affect the early metabolic, transcriptional, and functional adaption of human and murine mononuclear phagocytes.
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