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6942. Aspirin decreases hepatocellular carcinoma risk in hepatitis C virus carriers: a nationwide cohort study.
作者: Yen-Hsiang Liao.;Ren-Jun Hsu.;Tzu-Hwei Wang.;Chen-Ta Wu.;Sheng-Yao Huang.;Chung-Y Hsu.;Yuan-Chih Su.;Wen-Lin Hsu.;Dai-Wei Liu.
来源: BMC Gastroenterol. 2020年20卷1期6页
Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers. However, the association, if any, between aspirin use and HCC in hepatitis C virus (HCV) carriers is unknown. Therefore, this study compared the occurrence rates of HCC in HCV carriers treated with or without aspirin.
6943. Prevalence of Rome IV Functional Bowel Disorders Among Adults in the United States, Canada, and the United Kingdom.
作者: Olafur S Palsson.;William Whitehead.;Hans Törnblom.;Ami D Sperber.;Magnus Simren.
来源: Gastroenterology. 2020年158卷5期1262-1273.e3页
Little is known about the population prevalence or demographic distributions of Rome IV functional bowel disorders (FBDs) or their effects on quality of life. We examined these in a multinational survey.
6944. Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice.
作者: Sydney Lavoie.;Eunyoung Chun.;Sena Bae.;Caitlin A Brennan.;Carey Ann Gallini Comeau.;Jessica K Lang.;Monia Michaud.;Hamid R Hoveyda.;Graeme L Fraser.;Miles H Fuller.;Brian T Layden.;Jonathan N Glickman.;Wendy S Garrett.
来源: Gastroenterology. 2020年158卷5期1359-1372.e9页
Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free fatty acid receptor 2 (FFAR2), a receptor for short-chain fatty acids that can affect the composition of the intestinal microbiome, contributes to the pathogenesis of CRC.
6946. Autophagy of Intestinal Epithelial Cells Inhibits Colorectal Carcinogenesis Induced by Colibactin-Producing Escherichia coli in ApcMin/+ Mice.
作者: Cécily Lucas.;Laurène Salesse.;My Hanh Thi Hoang.;Mathilde Bonnet.;Pierre Sauvanet.;Anaïs Larabi.;Catherine Godfraind.;Johan Gagnière.;Denis Pezet.;Philip Rosenstiel.;Nicolas Barnich.;Richard Bonnet.;Guillaume Dalmasso.;Hang Thi Thu Nguyen.
来源: Gastroenterology. 2020年158卷5期1373-1388页
Colibactin-producing Escherichia coli (CoPEC) colonize the colonic mucosa of a higher proportion of patients with vs without colorectal cancer (CRC) and promote colorectal carcinogenesis in susceptible mouse models of CRC. Autophagy degrades cytoplasmic contents, including intracellular pathogens, via lysosomes and regulates intestinal homeostasis. We investigated whether inhibiting autophagy affects colorectal carcinogenesis in susceptible mice infected with CoPEC.
6947. The challenging diagnosis and treatment of duodenal diverticulum perforation: a report of two cases.
作者: Moysis Moysidis.;Daniel Paramythiotis.;Anestis Karakatsanis.;Evropi Amanatidou.;Elisavet Psoma.;Xanthippi Mavropoulou.;Antonios Michalopoulos.
来源: BMC Gastroenterol. 2020年20卷1期5页
The duodenum is a common site for diverticulum formation. Most of the duodenal diverticula are asymptomatic, incidental findings. Perforation is a rare but potentially lethal complication of duodenal diverticular disease. Surgery remains the mainstay of treatment for perforated duodenal diverticula. In recent years, a few cases were successfully managed either conservatively or with endoscopy.
6951. Non-selective beta blocker use is associated with improved short-term survival in patients with cirrhosis referred for liver transplantation.
作者: Taiwo Ngwa.;Eric Orman.;Eduardo Vilar Gomez.;Raj Vuppalanchi.;Chandrashekhar Kubal.;Naga Chalasani.;Marwan Ghabril.
来源: BMC Gastroenterol. 2020年20卷1期4页
Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in patients with cirrhosis referred for liver transplantation.
6954. Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.
作者: Neil Murphy.;Robert Carreras-Torres.;Mingyang Song.;Andrew T Chan.;Richard M Martin.;Nikos Papadimitriou.;Niki Dimou.;Konstantinos K Tsilidis.;Barbara Banbury.;Kathryn E Bradbury.;Jelena Besevic.;Sabina Rinaldi.;Elio Riboli.;Amanda J Cross.;Ruth C Travis.;Claudia Agnoli.;Demetrius Albanes.;Sonja I Berndt.;Stéphane Bézieau.;D Timothy Bishop.;Hermann Brenner.;Daniel D Buchanan.;N Charlotte Onland-Moret.;Andrea Burnett-Hartman.;Peter T Campbell.;Graham Casey.;Sergi Castellví-Bel.;Jenny Chang-Claude.;María-Dolores Chirlaque.;Albert de la Chapelle.;Dallas English.;Jane C Figueiredo.;Steven J Gallinger.;Graham G Giles.;Stephen B Gruber.;Andrea Gsur.;Jochen Hampe.;Heather Hampel.;Tabitha A Harrison.;Michael Hoffmeister.;Li Hsu.;Wen-Yi Huang.;Jeroen R Huyghe.;Mark A Jenkins.;Temitope O Keku.;Tilman Kühn.;Sun-Seog Kweon.;Loic Le Marchand.;Christopher I Li.;Li Li.;Annika Lindblom.;Vicente Martín.;Roger L Milne.;Victor Moreno.;Polly A Newcomb.;Kenneth Offit.;Shuji Ogino.;Jennifer Ose.;Vittorio Perduca.;Amanda I Phipps.;Elizabeth A Platz.;John D Potter.;Conghui Qu.;Gad Rennert.;Lori C Sakoda.;Clemens Schafmayer.;Robert E Schoen.;Martha L Slattery.;Catherine M Tangen.;Cornelia M Ulrich.;Franzel J B van Duijnhoven.;Bethany Van Guelpen.;Kala Visvanathan.;Pavel Vodicka.;Ludmila Vodickova.;Veronika Vymetalkova.;Hansong Wang.;Emily White.;Alicja Wolk.;Michael O Woods.;Anna H Wu.;Wei Zheng.;Ulrike Peters.;Marc J Gunter.
来源: Gastroenterology. 2020年158卷5期1300-1312.e20页
Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development.
6960. Prevalence of Gastroesophageal Reflux Disease and Proton Pump Inhibitor-Refractory Symptoms.
作者: Sean D Delshad.;Christopher V Almario.;William D Chey.;Brennan M R Spiegel.
来源: Gastroenterology. 2020年158卷5期1250-1261.e2页
There are few data on the prevalence of gastroesophageal reflux disease (GERD) in the United States. We performed a population-based study to determine the prevalence of GERD symptoms and persistent GERD symptoms despite use of proton pump inhibitors (PPIs).
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