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6921. Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review.
作者: Nami Sato.;Shigetsugu Takano.;Hideyuki Yoshitomi.;Katsunori Furukawa.;Tsukasa Takayashiki.;Satoshi Kuboki.;Daisuke Suzuki.;Nozomu Sakai.;Shingo Kagawa.;Takashi Mishima.;Eri Nakadai.;Rintaro Mikata.;Naoya Kato.;Masayuki Ohtsuka.
来源: BMC Gastroenterol. 2020年20卷1期13页
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has high accuracy and a low complication rate; therefore, it has been widely used as a useful tool for diagnosis of and to determine treatment strategies for pancreatic tumors. Recently, reports of the recurrence of needle tract seeding after EUS-FNA are emerging.
6922. Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication.
作者: Shuangshuang Xie.;Hanxiong Qi.;Qing Li.;Kun Zhang.;Longjiang Zhang.;Yue Cheng.;Wen Shen.
来源: BMC Gastroenterol. 2020年20卷1期14页
To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl4)-induced rat model.
6923. Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.
作者: Toshiharu Sakurai.;Hiroki Nishiyama.;Tomoyuki Nagai.;Susumu Goto.;Hiroyuki Ogata.;Masatoshi Kudo.
来源: BMC Gastroenterol. 2020年20卷1期12页
Gankyrin (GK) is an oncoprotein which regulates inflammatory responses and its inhibition is considered as a possible anti-inflammatory therapy for inflammatory bowel disease (IBD).
6924. Associations between disease activity, social support and health-related quality of life in patients with inflammatory bowel diseases: the mediating role of psychological symptoms.
作者: Hanlin Fu.;Atipatsa Chiwanda Kaminga.;Yan Peng.;Tiejian Feng.;Tingting Wang.;Xiaobing Wu.;Tubao Yang.
来源: BMC Gastroenterol. 2020年20卷1期11页
Previous studies have indicated that disease activity, psychological symptoms and social support were associated with health-related quality of life (HRQoL) in patients with inflammatory bowel diseases(IBD). However, it is unclear how disease activity, psychological symptoms and social support interact to affect HRQoL. The main purpose of this study was to examine the mediation effect of psychological symptoms in the relationship between disease activity, social support and HRQoL.
6925. Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis.
作者: Xuefeng Ma.;Shousheng Liu.;Jie Zhang.;Mengzhen Dong.;Yifen Wang.;Mengke Wang.;Yongning Xin.
来源: BMC Gastroenterol. 2020年20卷1期10页
ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the summarized proportion of NAFLD patients with normal ALT value in the overall NAFLD patients.
6926. Approaching treatment for immunological rejection of living-donor liver transplantation in rats.
作者: Yanhu Feng.;Zhijian Han.;Zedong Feng.;Bofang Wang.;Huijuan Cheng.;Luxi Yang.;Yangbing Li.;Baohong Gu.;Xuemei Li.;Yahao Li.;Yumin Li.;Chen Wang.;Hao Chen.
来源: BMC Gastroenterol. 2020年20卷1期7页
The anti-immunological rejection therapy for small-for-size syndrome (SFSS) after live donor liver transplantation (LDLT) play a central role in keeping graft survival. The hepatocyte number and grafts function has undergone real-time changes with the proliferation and apoptosis of the grafts after reperfusion. Lacking an accurate and effective treatment regiments or indicators to guide the use of immunosuppressive drugs in SFS liver transplantation has made immunotherapy after SFS liver transplantation an urgent problem to be solved. Herein, we established small-for-size (SFS) and normal size liver transplantation model in rats to explore the effective indicators in guiding immunotherapy, to find an effective way for overcoming SFSS.
6927. A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.
作者: Nozomi Morita.;Chiaki Okuse.;Keigo Suetani.;Hiroyasu Nakano.;Tetsuya Hiraishi.;Shinya Ishigooka.;Shuzo Mori.;Tsukasa Shimamura.;Takeshi Asakura.;Junki Koike.;Fumio Itoh.;Michihiro Suzuki.
来源: BMC Gastroenterol. 2020年20卷1期9页
Epstein-Barr virus-positive mucocutaneous ulcer (EBV-MCU) is a new category of mature B-cell neoplasms. Ulcers occur in the oropharyngeal mucosa, skin, and gastrointestinal tract. The onset of EBV-MCU is suggested to be related to the decreased immunity of the patient, the causes of which include the use of immunosuppressive agents and aging. EBV-MCU may regress spontaneously and it often has a benign course after the dose reduction or discontinuation of immunosuppressive agents or during follow-up. Here, we report the case of a patient who required surgical resection for the intestinal obstruction arising from EBV-MCU.
6928. Complications of enterostomy and related risk factor analysis of very early onset inflammatory bowel disease with interleukin-10 signalling deficiency: a single-centre retrospective analysis.
作者: Zifei Tang.;Zhiheng Huang.;Weili Yan.;Yi Zhang.;Peng Shi.;Kuiran Dong.;Ying Gong.;Min Ji.;Yuhuan Wang.;Zhuowe Yu.;Ying Huang.
来源: BMC Gastroenterol. 2020年20卷1期8页
Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies in these surgical populations are lacking. This study aims to determine the enterostomy characteristics, postoperative complications and related risk factors in enterostomy patients.
6929. Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
作者: Atsushi Masamune.;Hiroshi Kotani.;Franziska Lena Sörgel.;Jian-Min Chen.;Shin Hamada.;Reiko Sakaguchi.;Emmanuelle Masson.;Eriko Nakano.;Yoichi Kakuta.;Tetsuya Niihori.;Ryo Funayama.;Matsuyuki Shirota.;Tatsuya Hirano.;Tetsuya Kawamoto.;Atsuki Hosokoshi.;Kiyoshi Kume.;Lara Unger.;Maren Ewers.;Helmut Laumen.;Peter Bugert.;Masayuki X Mori.;Volodymyr Tsvilovskyy.;Petra Weißgerber.;Ulrich Kriebs.;Claudia Fecher-Trost.;Marc Freichel.;Kalliope N Diakopoulos.;Alexandra Berninger.;Marina Lesina.;Kentaro Ishii.;Takao Itoi.;Tsukasa Ikeura.;Kazuichi Okazaki.;Tom Kaune.;Jonas Rosendahl.;Masao Nagasaki.;Yasuhito Uezono.;Hana Algül.;Keiko Nakayama.;Yoichi Matsubara.;Yoko Aoki.;Claude Férec.;Yasuo Mori.;Heiko Witt.;Tooru Shimosegawa.
来源: Gastroenterology. 2020年158卷6期1626-1641.e8页
Changes in pancreatic calcium levels affect secretion and might be involved in development of chronic pancreatitis (CP). We investigated the association of CP with the transient receptor potential cation channel subfamily V member 6 gene (TRPV6), which encodes a Ca2+-selective ion channel, in an international cohort of patients and in mice.
6930. LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.
作者: Yajing Gao.;Yan Yan.;Sushil Tripathi.;Nalle Pentinmikko.;Ana Amaral.;Pekka Päivinen.;Eva Domènech-Moreno.;Simon Andersson.;Iris P L Wong.;Hans Clevers.;Pekka Katajisto.;Tomi P Mäkelä.
来源: Gastroenterology. 2020年158卷5期1389-1401.e10页
In addition to the Notch and Wnt signaling pathways, energy metabolism also regulates intestinal stem cell (ISC) function. Tumor suppressor and kinase STK11 (also called LKB1) regulates stem cells and cell metabolism. We investigated whether loss of LKB1 alters ISC homeostasis in mice.
6932. Microbial Diversity in Clinical Microbiome Studies: Sample Size and Statistical Power Considerations.
作者: Climent Casals-Pascual.;Antonio González.;Yoshiki Vázquez-Baeza.;Se Jin Song.;Lingjing Jiang.;Rob Knight.
来源: Gastroenterology. 2020年158卷6期1524-1528页 6933. Risk Factors for Early-Onset Colorectal Cancer.
作者: Eric E Low.;Joshua Demb.;Lin Liu.;Ashley Earles.;Ranier Bustamante.;Christina D Williams.;Dawn Provenzale.;Tonya Kaltenbach.;Andrew J Gawron.;Maria Elena Martinez.;Samir Gupta.
来源: Gastroenterology. 2020年159卷2期492-501.e7页
Colorectal cancer (CRC) incidence and mortality are increasing among persons younger than 50 years old in the United States, but risk factors associated with early-onset CRC (EOCRC) have not been widely studied.
6936. Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.
作者: Christoph Engel.;Aysel Ahadova.;Toni T Seppälä.;Stefan Aretz.;Marloes Bigirwamungu-Bargeman.;Hendrik Bläker.;Karolin Bucksch.;Reinhard Büttner.;Wouter T de Vos Tot Nederveen Cappel.;Volker Endris.;Elke Holinski-Feder.;Stefanie Holzapfel.;Robert Hüneburg.;Maarten A J M Jacobs.;Jan J Koornstra.;Alexandra M Langers.;Anna Lepistö.;Monika Morak.;Gabriela Möslein.;Päivi Peltomäki.;Kirsi Pylvänäinen.;Nils Rahner.;Laura Renkonen-Sinisalo.;Karsten Schulmann.;Verena Steinke-Lange.;Albrecht Stenzinger.;Christian P Strassburg.;Paul C van de Meeberg.;Mariette van Kouwen.;Monique van Leerdam.;Deepak B Vangala.;Juda Vecht.;Marie-Louise Verhulst.;Magnus von Knebel Doeberitz.;Jürgen Weitz.;Silke Zachariae.;Markus Loeffler.;Jukka-Pekka Mecklin.;Matthias Kloor.;Hans F Vasen.; .; .
来源: Gastroenterology. 2020年158卷5期1326-1333页
Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with Lynch syndrome, CRCs can develop via different pathways. We studied associations between Lynch syndrome-associated variants in MMR genes and risks of adenoma and CRC and somatic mutations in APC and CTNNB1 in tumors in an international cohort of patients.
6938. Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-Analysis.
作者: Pablo A Olivera.;Juan S Lasa.;Stefanos Bonovas.;Silvio Danese.;Laurent Peyrin-Biroulet.
来源: Gastroenterology. 2020年158卷6期1554-1573.e12页
Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative colitis, but there are safety concerns. We performed a systematic review and meta-analysis to investigate the safety profile of tofacitinib, upadacitinib, filgotinib, and baricitinib in patients with rheumatoid arthritis, inflammatory bowel diseases, psoriasis, or ankylosing spondylitis.
6939. Causes of Post-Colonoscopy Colorectal Cancers Based on World Endoscopy Organization System of Analysis.
作者: Rebecca Anderson.;Nicholas E Burr.;Roland Valori.
来源: Gastroenterology. 2020年158卷5期1287-1299.e2页
Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cases of PCCRC and the factors that cause them, test the WEO system of categorization, quantify the proportion of avoidable PCCRCs, and propose a target rate for PCCRCs detected within 3 years of a colonoscopy that did not detect CRC.
6940. Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study.
作者: Hamed Khalili.;Kristin E Burke.;Bjorn Roelstraete.;Michael C Sachs.;Ola Olén.;Jonas F Ludvigsson.
来源: Gastroenterology. 2020年158卷6期1574-1583.e2页
Microscopic colitis shares pathogenetic mechanisms with inflammatory bowel disease (IBD). We studied the association between microscopic colitis and risk of incident IBD using data from a nationwide cohort study.
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