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6861. Elobixibat alleviates chronic constipation in hemodialysis patients: a questionnaire-based study.
作者: Daigo Kamei.;Yuiko Kamei.;Masashi Nagano.;Michio Mineshima.;Kosaku Nitta.;Ken Tsuchiya.
来源: BMC Gastroenterol. 2020年20卷1期26页
Hemodialysis patients are prone to constipation, which can adversely affect their quality of life (QOL). Elobixibat, a highly selective inhibitor of the ileal bile acid transporter, can increase the bile acid level in the colon and, subsequently, enhance colonic motility and secretion. In hemodialysis patients with chronic constipation, it may have a novel action mechanism. However, the effect of elobixibat on such patients' QOL had not been reported. This study aimed to evaluate the effect of elobixibat on the QOL of hemodialysis patients with chronic constipation.
6862. Prevention and management of diarrhea associated with naldemedine among patients receiving opioids: a retrospective cohort study.
作者: Yusuke Takagi.;Gakuji Osawa.;Yoriko Kato.;Eri Ikezawa.;Chika Kobayashi.;Etsuko Aruga.
来源: BMC Gastroenterol. 2020年20卷1期25页
Naldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, which can cause abdominal pain and often leads to treatment discontinuation. We aimed to identify risk factors and appropriate management strategies for key adverse events including diarrhea associated with naldemedine, since those have not been extensively studied.
6864. Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice.
作者: Thomas Michler.;Anna D Kosinska.;Julia Festag.;Till Bunse.;Jinpeng Su.;Marc Ringelhan.;Hortenzia Imhof.;Dirk Grimm.;Katja Steiger.;Carolin Mogler.;Mathias Heikenwalder.;Marie-Louise Michel.;Carlos A Guzman.;Stuart Milstein.;Laura Sepp-Lorenzino.;Percy Knolle.;Ulrike Protzer.
来源: Gastroenterology. 2020年158卷6期1762-1775.e9页
Hepatitis B virus (HBV) infection persists because the virus-specific immune response is dysfunctional. Therapeutic vaccines might be used to end immune tolerance to the virus in patients with chronic infection, but these have not been effective in patients so far. In patients with chronic HBV infection, high levels of virus antigens might prevent induction of HBV-specific immune responses. We investigated whether knocking down expression levels of HBV antigens in liver might increase the efficacy of HBV vaccines in mice.
6865. Gastric tuberculosis mimicking submucosal tumor: a case series.
作者: Rong Zhu.;Yuankun Zhou.;Haibo Wang.;Lianjun Di.;Kui Zhao.;Biguang Tuo.;Huichao Wu.
来源: BMC Gastroenterol. 2020年20卷1期23页
Gastric tuberculosis mimicking submucosal tumors is extremely rare and often misdiagnosed.
6866. Patient characteristics, clinical manifestations, prognosis, and factors associated with gastrointestinal cytomegalovirus infection in immunocompetent patients.
作者: Thanaboon Chaemsupaphan.;Julajak Limsrivilai.;Chenchira Thongdee.;Asawin Sudcharoen.;Ananya Pongpaibul.;Nonthalee Pausawasdi.;Phunchai Charatcharoenwitthaya.
来源: BMC Gastroenterol. 2020年20卷1期22页
Gastrointestinal (GI) cytomegaloviral (CMV) infection is common among patients with immunocompromised status; however, data specific to GI-CMV infection in immunocompetent patients are comparatively limited.
6867. High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: longitudinal analysis of a German cohort.
作者: Jan-Hendrik Bockmann.;Marcel Grube.;Vanessa Hamed.;Johann von Felden.;Johanna Landahl.;Malte Wehmeyer.;Katja Giersch.;Michaela T Hall.;John M Murray.;Maura Dandri.;Stefan Lüth.;Ansgar W Lohse.;Marc Lütgehetmann.;Julian Schulze Zur Wiesch.
来源: BMC Gastroenterol. 2020年20卷1期24页
Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognostic factors for disease outcome by analysing frequencies of clinical events and their correlation with baseline virological and biochemical parameters as well as interferon and nucleos(t)ide analogue treatment choice.
6868. Evaluation of ultrasound-guided Freka-Trelumina enteral nutrition tube placement in the treatment of acute pancreatitis.
作者: Zhijun Liu.;Jintao Guo.;Weidong Ren.;Shaoshan Tang.;Ying Huang.;Liping Huang.;Siyu Sun.;Lianjie Lin.
来源: BMC Gastroenterol. 2020年20卷1期21页
Enteral nutrition should be implemented as early as possible in patients with moderate or severe acute pancreatitis. This study was designed to evaluate the feasibility and Deffectiveness of ultrasound-guided Freka-Trelumina tube placement for enteral nutrition in acute pancreatitis.
6869. Efficacy of artichoke and ginger extracts with simethicone to treat gastrointestinal symptoms in endurance athletes: a pilot study.
作者: Franchek Drobnic.;Sergi Fonts.;Iker García-Alday.;Giovanna Petrangolini.;Antonella Riva.;Elisabetta Frattini.;Pietro Allegrini.;Stefano Togni.;Jacopo Vitale.
来源: Minerva Gastroenterol (Torino). 2022年68卷1期77-84页
Exercise-induced gastrointestinal (GI) symptoms are frequently reported by athletes during training and competitions. A standardized combination of artichoke leaves and ginger root extracts has shown beneficial effects in managing GI discomfort in otherwise healthy subjects.
6870. Comparison of the effects of adjuvant concurrent chemoradiotherapy and chemotherapy for resected biliary tract cancer.
Biliary tract cancers (BTC) have a poor prognosis even after curative resection because of frequent local and distant recurrences. Therefore, the importance of adjuvant therapy in BTC has been advocated to improve outcomes. However, the choice of adjuvant therapy is still controversial. The aim of this study was to compare the effects of adjuvant concurrent chemoradiotherapy (CCRT) and chemotherapy on resected BTC.
6871. Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease.
作者: Eleonora Scorletti.;Paul R Afolabi.;Elizabeth A Miles.;Debbie E Smith.;Amal Almehmadi.;Albandri Alshathry.;Caroline E Childs.;Stefania Del Fabbro.;Josh Bilson.;Helen E Moyses.;Geraldine F Clough.;Jaswinder K Sethi.;Janisha Patel.;Mark Wright.;David J Breen.;Charles Peebles.;Angela Darekar.;Richard Aspinall.;Andrew J Fowell.;Joanna K Dowman.;Valerio Nobili.;Giovanni Targher.;Nathalie M Delzenne.;Laure B Bindels.;Philip C Calder.;Christopher D Byrne.
来源: Gastroenterology. 2020年158卷6期1597-1610.e7页
Dysbiosis of the intestinal microbiota has been associated with nonalcoholic fatty liver disease (NAFLD). We investigated whether administration of a synbiotic combination of probiotic and prebiotic agents affected liver fat content, biomarkers of liver fibrosis, and the composition of the fecal microbiome in patients with NAFLD.
6872. Peritoneal Level of CD206 Associates With Mortality and an Inflammatory Macrophage Phenotype in Patients With Decompensated Cirrhosis and Spontaneous Bacterial Peritonitis.
作者: Sven Stengel.;Stefanie Quickert.;Philipp Lutz.;Oluwatomi Ibidapo-Obe.;Arndt Steube.;Nilay Köse-Vogel.;Melina Yarbakht.;Philipp A Reuken.;Martin Busch.;Annette Brandt.;Ina Bergheim.;Sachin D Deshmukh.;Andreas Stallmach.;Tony Bruns.
来源: Gastroenterology. 2020年158卷6期1745-1761页
Peritoneal macrophages (PMs) regulate inflammation and control bacterial infections in patients with decompensated cirrhosis. We aimed to characterize PMs and associate their activation with outcomes of patients with spontaneous bacterial peritonitis (SBP).
6876. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.
作者: Xiao Liu.;Jun Xu.;Sara Rosenthal.;Ling-Juan Zhang.;Ryan McCubbin.;Nairika Meshgin.;Linshan Shang.;Yukinori Koyama.;Hsiao-Yen Ma.;Sonia Sharma.;Sven Heinz.;Chris K Glass.;Chris Benner.;David A Brenner.;Tatiana Kisseleva.
来源: Gastroenterology. 2020年158卷6期1728-1744.e14页
Development of liver fibrosis is associated with activation of quiescent hepatic stellate cells (HSCs) into collagen type I-producing myofibroblasts (activated HSCs). Cessation of liver injury often results in fibrosis resolution and inactivation of activated HSCs/myofibroblasts into a quiescent-like state (inactivated HSCs). We aimed to identify molecular features of phenotypes of HSCs from mice and humans.
6877. Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men.
作者: Long H Nguyen.;Wenjie Ma.;Dong D Wang.;Yin Cao.;Himel Mallick.;Teklu K Gerbaba.;Jason Lloyd-Price.;Galeb Abu-Ali.;A Brantley Hall.;Daniel Sikavi.;David A Drew.;Raaj S Mehta.;Cesar Arze.;Amit D Joshi.;Yan Yan.;Tobyn Branck.;Casey DuLong.;Kerry L Ivey.;Shuji Ogino.;Eric B Rimm.;Mingyang Song.;Wendy S Garrett.;Jacques Izard.;Curtis Huttenhower.;Andrew T Chan.
来源: Gastroenterology. 2020年158卷5期1313-1325页
Sulfur-metabolizing microbes, which convert dietary sources of sulfur into genotoxic hydrogen sulfide (H2S), have been associated with development of colorectal cancer (CRC). We identified a dietary pattern associated with sulfur-metabolizing bacteria in stool and then investigated its association with risk of incident CRC using data from a large prospective study of men.
6878. High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice.
作者: Wen-Hao Qin.;Zhi-Shi Yang.;Mian Li.;Yao Chen.;Xiao-Fang Zhao.;Ying-Yi Qin.;Jia-Qi Song.;Bi-Bo Wang.;Bo Yuan.;Xiu-Liang Cui.;Feng Shen.;Jia He.;Yu-Fang Bi.;Guang Ning.;Jing Fu.;Hong-Yang Wang.
来源: Gastroenterology. 2020年158卷6期1713-1727页
The relationship between serum cholesterol level and development of hepatocellular carcinoma (HCC) remains unclear. We investigated the effects of serum cholesterol level on development of liver tumors in mice.
6880. Antibiotic Prophylaxis Is Not Required for Endoscopic Ultrasonography-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions, Based on a Randomized Trial.
作者: Juan Colán-Hernández.;Oriol Sendino.;Carme Loras.;Albert Pardo.;Joan B Gornals.;Mar Concepción.;Cristina Sánchez-Montes.;Marianette Murzi.;Xavier Andujar.;Julio Velasquez-Rodriguez.;Cristina Rodriguez de Miguel.;Gloria Fernández-Esparrach.;Angels Ginés.;Carlos Guarner-Argente.
来源: Gastroenterology. 2020年158卷6期1642-1649.e1页
Guidelines recommend routine antibiotic prophylaxis for patients undergoing endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) of pancreatic cysts, but there is conflicting evidence for its necessity. We investigated whether performing the procedure without antimicrobial prophylaxis increases the incidence of infection.
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