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6801. Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling.
作者: Jay Vasant Patankar.;Mircea Teodor Chiriac.;Malte Lehmann.;Anja A Kühl.;Raja Atreya.;Christoph Becker.; .;Miguel Gonzalez-Acera.;Heike Schmitt.;Reyes Gamez-Belmonte.;Mousumi Mahapatro.;Leonard Diemand.;Leonie Hartmann.;Fabrizio Mascia.;Zsuzsanna Hracsko.;Veronika Thonn.;Lena Schödel.;Marta Zielinska.;Yuqiang Yu.;Lena Erkert.;Wei Li.;Melanie Zeitler.;Barbara Ruder.;Ingo Ganzleben.;Claudia Günther.;David Voehringer.;Sebastian Zundler.;Markus F Neurath.;Britta Siegmund.
来源: Gastroenterology. 2021年160卷3期925-928.e4页 6803. Winter Is Coming! Clinical, Immunologic, and Practical Considerations for Vaccinating Patients With Inflammatory Bowel Disease During the Coronavirus Disease-2019 Pandemic.6804. Colonoscopist Performance and Colorectal Cancer Risk After Adenoma Removal to Stratify Surveillance: Two Nationwide Observational Studies.
作者: Paulina Wieszczy.;Elisabeth Waldmann.;Magnus Løberg.;Jaroslaw Regula.;Maciej Rupinski.;Marek Bugajski.;Kathryn Gray.;Mette Kalager.;Monika Ferlitsch.;Michal F Kaminski.;Michael Bretthauer.
来源: Gastroenterology. 2021年160卷4期1067-1074.e6页
Colonoscopy surveillance after adenoma removal is an increasing burden in many countries. Surveillance recommendations consider characteristics of removed adenomas, but not colonoscopist performance. We investigated the impact of colonoscopist performance on colorectal cancer risk after adenoma removal.
6805. Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer.
作者: Junjie Huang.;Veeleah Lok.;Chun Ho Ngai.;Lin Zhang.;Jinqiu Yuan.;Xiang Qian Lao.;Kelvin Ng.;Charing Chong.;Zhi-Jie Zheng.;Martin C S Wong.
来源: Gastroenterology. 2021年160卷3期744-754页
We evaluated global and regional burdens of, risk factors for, and epidemiologic trends in pancreatic cancer among groups of different sexes and ages.
6806. Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis.
作者: Sayed Obaidullah Aseem.;Nidhi Jalan-Sakrikar.;Cheng Chi.;Amaia Navarro-Corcuera.;Thiago M De Assuncao.;Feda H Hamdan.;Shiraj Chowdhury.;Jesus M Banales.;Steven A Johnsen.;Vijay H Shah.;Robert C Huebert.
来源: Gastroenterology. 2021年160卷3期889-905.e10页
Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Using epigenomic and transcriptomic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of TGFβ that mediate transcription of fibrogenic signals.
6807. Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.
作者: Xingyi Guo.;Weiqiang Lin.;Wanqing Wen.;Jeroen Huyghe.;Stephanie Bien.;Qiuyin Cai.;Tabitha Harrison.;Zhishan Chen.;Conghui Qu.;Jiandong Bao.;Jirong Long.;Yuan Yuan.;Fangqin Wang.;Mengqiu Bai.;Goncalo R Abecasis.;Demetrius Albanes.;Sonja I Berndt.;Stéphane Bézieau.;D Timothy Bishop.;Hermann Brenner.;Stephan Buch.;Andrea Burnett-Hartman.;Peter T Campbell.;Sergi Castellví-Bel.;Andrew T Chan.;Jenny Chang-Claude.;Stephen J Chanock.;Sang Hee Cho.;David V Conti.;Albert de la Chapelle.;Edith J M Feskens.;Steven J Gallinger.;Graham G Giles.;Phyllis J Goodman.;Andrea Gsur.;Mark Guinter.;Marc J Gunter.;Jochen Hampe.;Heather Hampel.;Richard B Hayes.;Michael Hoffmeister.;Ellen Kampman.;Hyun Min Kang.;Temitope O Keku.;Hyeong Rok Kim.;Loic Le Marchand.;Soo Chin Lee.;Christopher I Li.;Li Li.;Annika Lindblom.;Noralane Lindor.;Roger L Milne.;Victor Moreno.;Neil Murphy.;Polly A Newcomb.;Deborah A Nickerson.;Kenneth Offit.;Rachel Pearlman.;Paul D P Pharoah.;Elizabeth A Platz.;John D Potter.;Gad Rennert.;Lori C Sakoda.;Clemens Schafmayer.;Stephanie L Schmit.;Robert E Schoen.;Fredrick R Schumacher.;Martha L Slattery.;Yu-Ru Su.;Catherine M Tangen.;Cornelia M Ulrich.;Franzel J B van Duijnhoven.;Bethany Van Guelpen.;Kala Visvanathan.;Pavel Vodicka.;Ludmila Vodickova.;Veronika Vymetalkova.;Xiaoliang Wang.;Emily White.;Alicja Wolk.;Michael O Woods.;Graham Casey.;Li Hsu.;Mark A Jenkins.;Stephen B Gruber.;Ulrike Peters.;Wei Zheng.
来源: Gastroenterology. 2021年160卷4期1164-1178.e6页
Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown. We conducted a transcriptome-wide association study (TWAS) to identify putative susceptibility genes.
6808. Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System.
作者: Samrat Yeramaneni.;Pratik Doshi.;Kenneth Sands.;Mandelin Cooper.;Dax Kurbegov.;Gregg Fromell.
来源: Gastroenterology. 2021年160卷3期919-921.e3页 6809. Race, Ethnicity, and Socioeconomic Status Are Associated With Prolonged Time to Treatment After a Diagnosis of Colorectal Cancer: A Large Population-Based Study.
作者: Aileen Bui.;Liu Yang.;Anthony Myint.;Folasade P May.
来源: Gastroenterology. 2021年160卷4期1394-1396.e3页 |