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6747. County Differences in Liver Mortality in the United States: Impact of Sociodemographics, Disease Risk Factors, and Access to Care.
作者: David Goldberg.;Katherine Ross-Driscoll.;Raymond Lynch.
来源: Gastroenterology. 2021年160卷4期1140-1150.e1页
Data have demonstrated state-wide variability in mortality rates from liver disease (cirrhosis + hepatocellular carcinoma), but data are lacking at the local level (eg, county) to identify factors associated with variability in liver disease-related mortality and hotspots of liver disease mortality.
6748. The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
作者: M Blanca Piazuelo.;Luis E Bravo.;Robertino M Mera.;M Constanza Camargo.;Juan C Bravo.;Alberto G Delgado.;M Kay Washington.;Alicia Rosero.;Luz S Garcia.;Jose L Realpe.;Sandra P Cifuentes.;Douglas R Morgan.;Richard M Peek.;Pelayo Correa.;Keith T Wilson.
来源: Gastroenterology. 2021年160卷4期1106-1117.e3页
Helicobacter pylori eradication and endoscopic surveillance of gastric precancerous lesions are strategies to reduce gastric cancer (GC) risk. To our knowledge, this study is the longest prospective cohort of an H pylori eradication trial in a Hispanic population.
6750. Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer.
作者: Kazuhiro Togasaki.;Shinya Sugimoto.;Yuki Ohta.;Kosaku Nanki.;Mami Matano.;Sirirat Takahashi.;Masayuki Fujii.;Takanori Kanai.;Toshiro Sato.
来源: Gastroenterology. 2021年160卷3期823-830页
Diffuse-type gastric cancer (GC) is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC, referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often coexist in the same tumors, raising a question of whether they clonally differ or not. To tackle this question, we established an experimental platform for human diffuse GC that enables accurate modeling of histologic subtypes.
6751. Colonoscopy With Polypectomy Reduces Long-Term Incidence of Colorectal Cancer in Both Men and Women: Extended Results From the Minnesota Colon Cancer Control Study.
作者: Aasma Shaukat.;Michael Shyne.;Jack S Mandel.;Dale Snover.;Timothy R Church.
来源: Gastroenterology. 2021年160卷4期1397-1399.e3页 6752. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.
作者: Huarong Chen.;Shanshan Gao.;Weixin Liu.;Chi-Chun Wong.;Jianfeng Wu.;Jingtong Wu.;Dabin Liu.;Hongyan Gou.;Wei Kang.;Jianning Zhai.;Chuangen Li.;Hao Su.;Shiyan Wang.;Fraser Soares.;Jiahuai Han.;Housheng Hansen He.;Jun Yu.
来源: Gastroenterology. 2021年160卷4期1284-1300.e16页
RNA N6-methyladenosine (m6A) modification has recently emerged as a new regulatory mechanism in cancer progression. We aimed to explore the role of the m6A regulatory enzyme METTL3 in colorectal cancer (CRC) pathogenesis and its potential as a therapeutic target.
6753. Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors.
作者: Rong Lu.;Yong-Guo Zhang.;Yinglin Xia.;Jilei Zhang.;Arthur Kaser.;Richard Blumberg.;Jun Sun.
来源: Gastroenterology. 2021年160卷4期1269-1283页
Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR). Although Paneth cells and their products are known to regulate the commensal and pathogenic microbiota, the role that VDRs in Paneth cells play in these responses is unknown.
6754. Single-Nucleus and In Situ RNA-Sequencing Reveal Cell Topographies in the Human Pancreas.
作者: Luca Tosti.;Yan Hang.;Olivia Debnath.;Sebastian Tiesmeyer.;Timo Trefzer.;Katja Steiger.;Foo Wei Ten.;Sören Lukassen.;Simone Ballke.;Anja A Kühl.;Simone Spieckermann.;Rita Bottino.;Naveed Ishaque.;Wilko Weichert.;Seung K Kim.;Roland Eils.;Christian Conrad.
来源: Gastroenterology. 2021年160卷4期1330-1344.e11页
Molecular evidence of cellular heterogeneity in the human exocrine pancreas has not been yet established because of the local concentration and cascade of hydrolytic enzymes that can rapidly degrade cells and RNA upon pancreatic resection. We sought to better understand the heterogeneity and cellular composition of the pancreas in neonates and adults in healthy and diseased conditions using single-cell sequencing approaches.
6755. Plasmid Acquisition Alters Vancomycin Susceptibility in Clostridioides difficile.
作者: Meng Pu.;Janice M Cho.;Scott A Cunningham.;Gaurav K Behera.;Sarah Becker.;Talal Amjad.;Kerryl E Greenwood-Quaintance.;Helena Mendes-Soares.;Yava Jones-Hall.;Patricio R Jeraldo.;Jun Chen.;Gary Dunny.;Robin Patel.;Purna C Kashyap.
来源: Gastroenterology. 2021年160卷3期941-945.e8页
The increasing incidence of primary and recurring Clostridioides difficile infections (CDI), which evade current treatment strategies, reflects the changing biology of C difficile. Here, we describe a putative plasmid-mediated mechanism potentially driving decreased sensitivity of C difficile to vancomycin treatment. We identified a broad host range transferable plasmid in a C difficile strain associated with lack of adequate response to vancomycin treatment. The transfer of this plasmid to a vancomycin-susceptible C difficile isolate decreased its susceptibility to vancomycin in vitro and resulted in more severe disease in a humanized mouse model. Our findings suggest plasmid acquisition in the gastrointestinal tract to be a possible mechanism underlying vancomycin treatment failure in patients with CDI, but further work is needed to characterize the mechanism by which plasmid genes determine vancomycin susceptibility in C difficile.
6756. The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
作者: Hiroki Kobayashi.;Krystyna A Gieniec.;Josephine A Wright.;Tongtong Wang.;Naoya Asai.;Yasuyuki Mizutani.;Tadashi Lida.;Ryota Ando.;Nobumi Suzuki.;Tamsin R M Lannagan.;Jia Q Ng.;Akitoshi Hara.;Yukihiro Shiraki.;Shinji Mii.;Mari Ichinose.;Laura Vrbanac.;Matthew J Lawrence.;Tarik Sammour.;Kay Uehara.;Gareth Davies.;Leszek Lisowski.;Ian E Alexander.;Yoku Hayakawa.;Lisa M Butler.;Andrew C W Zannettino.;M Omar Din.;Jeff Hasty.;Alastair D Burt.;Simon J Leedham.;Anil K Rustgi.;Siddhartha Mukherjee.;Timothy C Wang.;Atsushi Enomoto.;Masahide Takahashi.;Daniel L Worthley.;Susan L Woods.
来源: Gastroenterology. 2021年160卷4期1224-1239.e30页
Cancer-associated fibroblasts (CAFs), key constituents of the tumor microenvironment, either promote or restrain tumor growth. Attempts to therapeutically target CAFs have been hampered by our incomplete understanding of these functionally heterogeneous cells. Key growth factors in the intestinal epithelial niche, bone morphogenetic proteins (BMPs), also play a critical role in colorectal cancer (CRC) progression. However, the crucial proteins regulating stromal BMP balance and the potential application of BMP signaling to manage CRC remain largely unexplored.
6757. Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19.
作者: B Joseph Elmunzer.;Bethany J Wolf.;James M Scheiman.;William M Tierney.;Jason R Taylor.; .
来源: Gastroenterology. 2021年160卷4期1417-1422.e14页 6758. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.
作者: Alain P Gobert.;Olivier Boutaud.;Mohammad Asim.;Irene A Zagol-Ikapitte.;Alberto G Delgado.;Yvonne L Latour.;Jordan L Finley.;Kshipra Singh.;Thomas G Verriere.;Margaret M Allaman.;Daniel P Barry.;Kara M McNamara.;Johanna C Sierra.;Venkataraman Amarnath.;Mohammed N Tantawy.;Diane Bimczok.;M Blanca Piazuelo.;M Kay Washington.;Shilin Zhao.;Lori A Coburn.;Keith T Wilson.
来源: Gastroenterology. 2021年160卷4期1256-1268.e9页
Inflammation in the gastrointestinal tract may lead to the development of cancer. Dicarbonyl electrophiles, such as isolevuglandins (isoLGs), are generated from lipid peroxidation during the inflammatory response and form covalent adducts with amine-containing macromolecules. Thus, we sought to determine the role of dicarbonyl electrophiles in inflammation-associated carcinogenesis.
6759. A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.
作者: Anoop Kumar.;Shubha Priyamvada.;Yong Ge.;Dulari Jayawardena.;Megha Singhal.;Arivarasu N Anbazhagan.;Ishita Chatterjee.;Aneal Dayal.;Mitul Patel.;Kimia Zadeh.;Seema Saksena.;Waddah A Alrefai.;Ravinder K Gill.;Mojgan Zadeh.;Ni Zhao.;Mansour Mohamadzadeh.;Pradeep K Dudeja.
来源: Gastroenterology. 2021年160卷4期1240-1255.e3页
The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the loss of DRA remain elusive. Compromised barrier is a key event in IBD pathogenesis. The current studies were undertaken to elucidate the impact of DRA deficiency on epithelial barrier integrity and to define underlying mechanisms.
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