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6741. Derivation and Validation of a 10-Year Risk Score for Symptomatic Abdominal Aortic Aneurysm: Cohort Study of Nearly 500 000 Individuals.
作者: Paul Welsh.;Claire E Welsh.;Pardeep S Jhund.;Mark Woodward.;Rosemary Brown.;Jim Lewsey.;Carlos A Celis-Morales.;Frederick K Ho.;Daniel F MacKay.;Jason M R Gill.;Stuart R Gray.;S Vittal Katikireddi.;Jill P Pell.;John Forbes.;Naveed Sattar.
来源: Circulation. 2021年144卷8期604-614页
Abdominal aortic aneurysm (AAA) can occur in patients who are ineligible for routine ultrasound screening. A simple AAA risk score was derived and compared with current guidelines used for ultrasound screening of AAA.
6742. Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.
作者: Gabor Czibik.;Zaineb Mezdari.;Dogus Murat Altintas.;Juliette Bréhat.;Maria Pini.;Thomas d'Humières.;Thaïs Delmont.;Costin Radu.;Marielle Breau.;Hao Liang.;Cecile Martel.;Azania Abatan.;Rizwan Sarwar.;Ophélie Marion.;Suzain Naushad.;Yanyan Zhang.;Maissa Halfaoui.;Nadine Suffee.;Didier Morin.;Serge Adnot.;Stéphane Hatem.;Arash Yavari.;Daigo Sawaki.;Geneviève Derumeaux.
来源: Circulation. 2021年144卷7期559-574页
Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction. Recent metabolomics studies shed light on amino acids in aging. The present study aimed to dissect how aging leads to elevated plasma levels of the essential amino acid phenylalanine and how it may promote age-related cardiac dysfunction.
6743. Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia.
作者: Zhipeng Sun.;Luqi Wang.;Lu Han.;Yue Wang.;Yuan Zhou.;Qiang Li.;Yongquan Wu.;Shaletanati Talabieke.;Yunlong Hou.;Lulin Wu.;Ronghua Liu.;Zhiping Fu.;Hongjie You.;Bai-Yan Li.;Yuanyuan Zheng.;Dali Luo.
来源: Circulation. 2021年144卷10期788-804页
Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca2+ and regulate its release in the sarcoplasmic reticulum of skeletal and cardiac muscle, respectively. Human inherited diseases associated with mutations in CASQ1 or CASQ2 include malignant hyperthermia/environmental heat stroke (MH/EHS) and catecholaminergic polymorphic ventricular tachycardia. However, patients with an MH/EHS event often experience arrhythmia for which the underlying mechanism remains unknown.
6744. Safer Stroke-Dx Instrument: Identifying Stroke Misdiagnosis in the Emergency Department.
作者: Faddi G Saleh Velez.;Ronald Alvarado-Dyer.;Camila Bonin Pinto.;Jorge G Ortiz García.;Daryl Mchugh.;Jenny Lu.;Oleg Otlivanchik.;Brent L Flusty.;Ava L Liberman.;Shyam Prabhakaran.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷7期e007758页
Missed or delayed diagnosis of acute stroke, or false-negative stroke (FNS), at initial emergency department (ED) presentation occurs in ≈9% of confirmed stroke patients. Failure to rapidly diagnose stroke can preclude time-sensitive treatments, resulting in higher risks of severe sequelae and disability. In this study, we developed and tested a modified version of a structured medical record review tool, the Safer Dx Instrument, to identify FNS in a subgroup of hospitalized patients with stroke to gain insight into sources of ED stroke misdiagnosis.
6745. Letter by Viswanath and Ahmad Regarding Article, "National Trends of Sex Disparity in the American College of Cardiology/American Heart Association Guideline Writing Committee Authors Over 15 Years".6746. Response by Rai et al to Letter Regarding Article, "National Trends of Sex Disparity in the American College of Cardiology/American Heart Association Guideline Writing Committee Authors Over 15 Years".
作者: Devesh Rai.;Muhammad Waqas Tahir.;Syed Hamza Waheed.;Ankita Kapoor.;Ritambhara Pandey.;Kirolos Barssoum.;Adrija Hajra.;Mallory Balmer-Swain.;Erin D Michos.;Martha Gulati.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷7期e008115页 6747. Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia.
作者: Moritz Döbert.;Anna Nektaria Varouxaki.;An Chi Mu.;Argyro Syngelaki.;Anca Ciobanu.;Ranjit Akolekar.;Catalina De Paco Matallana.;Simona Cicero.;Elena Greco.;Mandeep Singh.;Deepa Janga.;Maria Del Mar Gil.;Jacques C Jani.;José Luis Bartha.;Kate Maclagan.;David Wright.;Kypros H Nicolaides.
来源: Circulation. 2021年144卷9期670-679页
Effective screening for term preeclampsia is provided by a combination of maternal factors with measurements of mean arterial pressure, serum placental growth factor, and serum soluble fms-like tyrosine kinase-1 at 35 to 37 weeks of gestation, with a detection rate of ≈75% at a screen-positive rate of 10%. However, there is no known intervention to reduce the incidence of the disease.
6748. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
作者: Taijyu Satoh.;Longfei Wang.;Cristina Espinosa-Diez.;Bing Wang.;Scott A Hahn.;Kentaro Noda.;Elizabeth R Rochon.;Matthew R Dent.;Andrea R Levine.;Jeffrey J Baust.;Samuel Wyman.;Yijen L Wu.;Georgios A Triantafyllou.;Ying Tang.;Mike Reynolds.;Sruti Shiva.;Cynthia St Hilaire.;Delphine Gomez.;Dmitry A Goncharov.;Elena A Goncharova.;Stephen Y Chan.;Adam C Straub.;Yen-Chun Lai.;Charles F McTiernan.;Mark T Gladwin.
来源: Circulation. 2021年144卷8期615-637页
Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved ejection fraction portend a poor prognosis; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (CpcPH). Therapeutic trials for EIPH and CpcPH have been disappointing, suggesting the need for strategies that target upstream mechanisms of disease. This work reports novel rat EIPH models and mechanisms of pulmonary vascular dysfunction centered around the transcriptional repression of the soluble guanylate cyclase (sGC) enzyme in pulmonary artery (PA) smooth muscle cells.
6749. Interim Guidance for Emergency Medical Services Management of Out-of-Hospital Cardiac Arrest During the COVID-19 Pandemic.
作者: Jeffrey M Goodloe.;Alexis Topjian.;Antony Hsu.;Robert Dunne.;Ashish R Panchal.;Michael Levy.;Mike McEvoy.;Christian Vaillancourt.;Jose G Cabanas.;Mickey S Eisenberg.;Thomas D Rea.;Peter J Kudenchuk.;Andy Gienapp.;Gustavo E Flores.;Susan Fuchs.;Kathleen M Adelgais.;Sylvia Owusu-Ansah.;Mark Terry.;Kelly N Sawyer.;Peter Fromm.;Micah Panczyk.;Michael Kurz.;George Lindbeck.;David K Tan.;Dana P Edelson.;Michael R Sayre.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷7期e007666页 6750. Transcatheter Left Atrial Appendage Closure Using Preprocedural Computed Tomography and Intraprocedural 4-Dimensional Intracardiac Echocardiography.
作者: Lauren S Ranard.;Omar K Khalique.;Elena Donald.;Vratika Agarwal.;Nadira Hamid.;Rebecca T Hahn.;Vivian Ng.;Matthew Brady.;Arati Gurung.;Ziad A Ali.;Martin B Leon.;Robert Sommer.;Torsten P Vahl.
来源: Circ Cardiovasc Interv. 2021年14卷7期e010686页 6753. Left Ventricular Intramyocardial Dissecting Hematoma: A Multimodality Imaging Diagnostic Approach.
作者: Tareq Alyousef.;Saurabh Malhotra.;Fady Iskander.;Javier Gomez.;Anupam Basu.;Jonathan Tottleben.;Rami Doukky.
来源: Circ Cardiovasc Imaging. 2021年14卷7期e012410页 6754. Correction to: A Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes: The Rapid Assessment of Possible Acute Coronary Syndrome in the Emergency Department With High-Sensitivity Troponin T Study (RAPID-TnT).
来源: Circulation. 2021年143卷25期e1118页
6759. Response to Sarayani et al Regarding Article, "Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque".
作者: Zsofia D Drobni.;Thomas Mayrhofer.;Udo Hoffmann.;Tomas G Neilan.
来源: Circulation. 2021年143卷25期e1033-e1034页 |