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6663. Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort.
作者: Kyle Gettler.;Rachel Levantovsky.;Arden Moscati.;Mamta Giri.;Yiming Wu.;Nai-Yun Hsu.;Ling-Shiang Chuang.;Aleksejs Sazonovs.;Suresh Venkateswaran.;Ujunwa Korie.;Colleen Chasteau.; .;Richard H Duerr.;Mark S Silverberg.;Scott B Snapper.;Mark J Daly.;Dermot P McGovern.;Steven R Brant.;John D Rioux.;Subra Kugathasan.;Carl A Anderson.;Yuval Itan.;Judy H Cho.
来源: Gastroenterology. 2021年160卷5期1546-1557页
Polygenic risk scores (PRS) may soon be used to predict inflammatory bowel disease (IBD) risk in prevention efforts. We leveraged exome-sequence and single nucleotide polymorphism (SNP) array data from 29,358 individuals in the multiethnic, randomly ascertained health system-based BioMe biobank to define effects of common and rare IBD variants on disease prediction and pathophysiology.
6667. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.
作者: Dan Turner.;Amanda Ricciuto.;Ayanna Lewis.;Ferdinando D'Amico.;Jasbir Dhaliwal.;Anne M Griffiths.;Dominik Bettenworth.;William J Sandborn.;Bruce E Sands.;Walter Reinisch.;Jürgen Schölmerich.;Willem Bemelman.;Silvio Danese.;Jean Yves Mary.;David Rubin.;Jean-Frederic Colombel.;Laurent Peyrin-Biroulet.;Iris Dotan.;Maria T Abreu.;Axel Dignass.; .
来源: Gastroenterology. 2021年160卷5期1570-1583页
The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment targets in 2015 for adult patients with inflammatory bowel disease (IBD). We aimed to update the original STRIDE statements for incorporating treatment targets in both adult and pediatric IBD.
6668. Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.
作者: Joseph C Devlin.;Jordan Axelrad.;Ashley M Hine.;Shannon Chang.;Suparna Sarkar.;Jian-Da Lin.;Kelly V Ruggles.;David Hudesman.;Ken Cadwell.;P'ng Loke.
来源: Gastroenterology. 2021年160卷5期1679-1693页
Restorative proctocolectomy with ileal pouch-anal anastomosis is a surgical procedure in patients with ulcerative colitis refractory to medical therapies. Pouchitis, the most common complication, is inflammation of the pouch of unknown etiology. To define how the intestinal immune system is distinctly organized during pouchitis, we analyzed tissues from patients with and without pouchitis and from patients with ulcerative colitis using single-cell RNA sequencing (scRNA-seq).
6674. Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases.
The intestinal microbiota comprises diverse fungal and viral components, in addition to bacteria. These microbes interact with the immune system and affect human physiology. Advances in metagenomics have associated inflammatory and autoimmune diseases with alterations in fungal and viral species in the gut. Studies of animal models have found that commensal fungi and viruses can activate host-protective immune pathways related to epithelial barrier integrity, but can also induce reactions that contribute to events associated with inflammatory bowel disease. Changes in our environment associated with modernization and the COVID-19 pandemic have exposed humans to new fungi and viruses, with unknown consequences. We review the lessons learned from studies of animal viruses and fungi commonly detected in the human gut and how these might affect health and intestinal disease.
6675. An International Multicenter Real-Life Prospective Study of Electronic Chromoendoscopy Score PICaSSO in Ulcerative Colitis.
作者: Marietta Iacucci.;Samuel C L Smith.;Alina Bazarova.;Uday N Shivaji.;Pradeep Bhandari.;Rosanna Cannatelli.;Marco Daperno.;Jose Ferraz.;Martin Goetz.;Xianyong Gui.;Bu Hayee.;Gert De Hertogh.;Mark Lazarev.;Jim Li.;Olga M Nardone.;Adolfo Parra-Blanco.;Luca Pastorelli.;Remo Panaccione.;Vincenzo Occhipinti.;Timo Rath.;Gian Eugenio Tontini.;Michael Vieth.;Vincenzo Villanacci.;Davide Zardo.;Raf Bisschops.;Ralf Kiesslich.;Subrata Ghosh.
来源: Gastroenterology. 2021年160卷5期1558-1569.e8页
Endoscopic and histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre (PICaSSO) and other established endoscopic scores against multiple histological indices and prospectively assessed outcomes.
6676. Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease.
作者: Oveis Jamialahmadi.;Rosellina Margherita Mancina.;Ester Ciociola.;Federica Tavaglione.;Panu K Luukkonen.;Guido Baselli.;Francesco Malvestiti.;Dorothée Thuillier.;Violeta Raverdy.;Ville Männistö.;Rosaria Maria Pipitone.;Grazia Pennisi.;Daniele Prati.;Rocco Spagnuolo.;Salvatore Petta.;Jussi Pihlajamäki.;François Pattou.;Hannele Yki-Järvinen.;Luca Valenti.;Stefano Romeo.
来源: Gastroenterology. 2021年160卷5期1634-1646.e7页
Fatty liver disease (FLD) is a growing epidemic that is expected to be the leading cause of end-stage liver disease within the next decade. Both environmental and genetic factors contribute to the susceptibility of FLD. Several genetic variants contributing to FLD have been identified in exome-wide association studies. However, there is still a missing hereditability indicating that other genetic variants are yet to be discovered.
6677. Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia.
作者: Lucas Wauters.;Matthias Ceulemans.;Dennis Frings.;Maarten Lambaerts.;Alison Accarie.;Joran Toth.;Raf Mols.;Patrick Augustijns.;Gert De Hertogh.;Lukas Van Oudenhove.;Jan Tack.;Tim Vanuytsel.
来源: Gastroenterology. 2021年160卷5期1521-1531.e9页
Despite the growing recognition of duodenal alterations in the pathophysiology of functional dyspepsia (FD), the effect and mechanism of proton pump inhibitors (PPIs) or first-line therapy remain unclear. We studied duodenal and systemic alterations in relation to PPI therapy in patients with FD and healthy volunteers (HVs).
6680. Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.
作者: Yuta Myojin.;Hayato Hikita.;Masaya Sugiyama.;Yoichi Sasaki.;Kenji Fukumoto.;Sadatsugu Sakane.;Yuki Makino.;Nobuyuki Takemura.;Ryoko Yamada.;Minoru Shigekawa.;Takahiro Kodama.;Ryotaro Sakamori.;Shogo Kobayashi.;Tomohide Tatsumi.;Hiroshi Suemizu.;Hidetoshi Eguchi.;Norihiro Kokudo.;Masashi Mizokami.;Tetsuo Takehara.
来源: Gastroenterology. 2021年160卷5期1741-1754.e16页
Although the tumor microenvironment plays an important role in tumor growth, it is not fully understood what role hepatic stellate cells (HSCs) play in the hepatocellular carcinoma (HCC) microenvironment.
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