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6581. hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome.
作者: Dong Zhou.;Hao Feng.;Ying Yang.;Tingting Huang.;Ping Qiu.;Chengxin Zhang.;Timothy R Olsen.;Jifeng Zhang.;Y Eugene Chen.;Dogukan Mizrak.;Bo Yang.
来源: Circulation. 2021年144卷14期1145-1159页
Loeys-Dietz syndrome (LDS) is an inherited disorder predisposing individuals to thoracic aortic aneurysm and dissection. Currently, there are no medical treatments except surgical resection. Although the genetic basis of LDS is well-understood, molecular mechanisms underlying the disease remain elusive, impeding the development of a therapeutic strategy. In addition, aortic smooth muscle cells (SMCs) have heterogenous embryonic origins, depending on their spatial location, and lineage-specific effects of pathogenic variants on SMC function, likely causing regionally constrained LDS manifestations, have been unexplored.
6582. Measured Versus Estimated Resting Metabolic Rate in Heart Failure With Preserved Ejection Fraction.
作者: Theresa Anderson.;Thomas M Cascino.;Todd M Koelling.;Daniel Perry.;Gillian Grafton.;Denise K Houston.;Bharathi Upadhya.;Dalane W Kitzman.;Scott L Hummel.
来源: Circ Heart Fail. 2021年14卷8期e007962页
Obesity is common in heart failure with preserved ejection fraction (HFpEF), and a hypocaloric diet can improve functional capacity. Malnutrition, sarcopenia, and frailty are also frequently present, and calorie restriction could harm some patients. Resting metabolic rate (RMR) is an essential determinant of caloric needs; however, it is rarely measured in clinical practice. The accuracy of commonly used predictive equations in HFpEF is unknown.
6583. Safety of Endomyocardial Biopsy in New-Onset Acute Heart Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation.
作者: Robert M A van der Boon.;Wijnand K den Dekker.;Christiaan L Meuwese.;Roberto Lorusso.;Jan H von der Thüsen.;Alina C Constantinescu.;Olivier C Manintveld.;Thijs S R Delnoij.;Joris J van der Heijden.;Nicolas M D A van Mieghem.;Corstiaan A den Uil.
来源: Circ Heart Fail. 2021年14卷8期e008387页
Endomyocardial biopsy (EMB) has an important role in determining the pathogenesis of new-onset acute heart failure (new-AHF) when noninvasive testing is impossible. However, data on safety and histopathologic outcomes in patients requiring veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is lacking.
6585. External Validations of Cardiovascular Clinical Prediction Models: A Large-Scale Review of the Literature.
作者: Benjamin S Wessler.;Jason Nelson.;Jinny G Park.;Hannah McGinnes.;Gaurav Gulati.;Riley Brazil.;Ben Van Calster.;David van Klaveren.;Esmee Venema.;Ewout Steyerberg.;Jessica K Paulus.;David M Kent.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷8期e007858页
There are many clinical prediction models (CPMs) available to inform treatment decisions for patients with cardiovascular disease. However, the extent to which they have been externally tested, and how well they generally perform has not been broadly evaluated.
6588. Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease.
作者: Christopher A Rajkumar.;Matthew Shun-Shin.;Henry Seligman.;Yousif Ahmad.;Takayuki Warisawa.;Christopher M Cook.;James P Howard.;Sashiananthan Ganesananthan.;Laura Amarin.;Caitlin Khan.;Ayesha Ahmed.;Alexandra Nowbar.;Michael Foley.;Ravi Assomull.;Niall G Keenan.;Joban Sehmi.;Thomas R Keeble.;John R Davies.;Kare H Tang.;Robert Gerber.;Graham Cole.;Peter O'Kane.;Andrew S P Sharp.;Ramzi Khamis.;Gajen Kanaganayagam.;Ricardo Petraco.;Neil Ruparelia.;Iqbal S Malik.;Sukhjinder Nijjer.;Sayan Sen.;Darrel P Francis.;Rasha Al-Lamee.
来源: Circ Cardiovasc Interv. 2021年14卷8期e009891页
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6589. Effect of Percutaneous Left Ventricular Unloading on Coronary Flow and Cardiac Coronary Coupling in Patients Undergoing High-Risk Percutaneous Coronary Intervention.
作者: Natalia Briceno.;Matthew Ryan.;Kevin O'Gallagher.;Tiffany Patterson.;Simone Rivolo.;Jack Lee.;Peter O'Kane.;Simon R Redwood.;Ajay M Shah.;Divaka Perera.
来源: Circ Cardiovasc Interv. 2021年14卷9期e010454页 6594. PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development.
作者: Ze'e Chen.;Siting Zhu.;Hong Wang.;Li Wang.;Jianlin Zhang.;Yusu Gu.;Changming Tan.;Mehul Dhanani.;Eric Wever.;Xinru Wang.;Boyu Xie.;Shijia Wang.;Lei Huang.;Antoine H C van Kampen.;Jie Liu.;Zhen Han.;Hemal H Patel.;Frédéric M Vaz.;Xi Fang.;Ju Chen.;Kunfu Ouyang.
来源: Circulation. 2021年144卷5期403-406页 6598. Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity.
作者: Tina E Brinkley.;Iris Leng.;Margie J Bailey.;Denise K Houston.;Christina E Hugenschmidt.;Barbara J Nicklas.;W Gregory Hundley.
来源: Circulation. 2021年144卷9期684-693页
Obesity may accelerate age-related increases in aortic stiffness. Although aerobic exercise training generally has favorable effects on aortic structure and function, exercise alone may not be sufficient to improve aortic stiffness in older adults with obesity. We determined the effects of aerobic exercise training with and without moderate- to high-caloric restriction (CR) on the structure and function of the proximal aorta in 160 older (65-79 years) men and women with obesity (body mass index=30-45 kg/m2).
6600. Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure.
作者: Andreas Rillig.;Christina Magnussen.;Ann-Kathrin Ozga.;Anna Suling.;Axel Brandes.;Günter Breithardt.;A John Camm.;Harry J G M Crijns.;Lars Eckardt.;Arif Elvan.;Andreas Goette.;Michele Gulizia.;Laurent Haegeli.;Hein Heidbuchel.;Karl-Heinz Kuck.;Andre Ng.;Lukasz Szumowski.;Isabelle van Gelder.;Karl Wegscheider.;Paulus Kirchhof.
来源: Circulation. 2021年144卷11期845-858页
Even on optimal therapy, many patients with heart failure and atrial fibrillation experience cardiovascular complications. Additional treatments are needed to reduce these events, especially in patients with heart failure and preserved left ventricular ejection fraction.
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