652. Resurgence of Zoonotic Highly Pathogenic Avian Influenza A(H5N1) Virus in Cambodia.
作者: Jurre Y Siegers.;Ruopeng Xie.;Kimberly M Edwards.;Alexander M P Byrne.;Shu Hu.;Ruixuan Wang.;Sokhoun Yann.;Sarath Sin.;Songha Tok.;Kimlay Chea.;Sreyviseth Horm.;Chenthearath Rith.;Seangmai Keo.;Leakhena Pum.;Veasna Duong.;Heidi Auerswald.;Yisuong Phou.;Sonita Kol.;Andre Spiegel.;Ruth Harvey.;Sothyra Tum.;San Sorn.;Bunnary Seng.;Yi Sengdoeurn.;Darapheak Chau.;Savuth Chin.;Makara Hak.;Vanra Ieng.;Sarika Patel.;Peter Thielen.;Filip F Claes.;Nicola S Lewis.;Sovann Ly.;Erik A Karlsson.;Vijaykrishna Dhanasekaran.
来源: N Engl J Med. 2025年393卷16期1650-1652页 657. Common Diseases in Clinical Cohorts - Not Always What They Seem.
作者: Fedik Rahimov.;Benjamin M Jacobs.;John S Lee.;Naim A Mahi.;Andrew Blumenfeld.;Ammar J Alsheikh.;Ali Abbasi.;Mark Reppell.;Valerie L Pivorunas.;Haukur J Sigurðsson.;Stephen Sawcer.;Heath Guay.;Jeffrey F Waring.;Howard J Jacob.;Nizar Smaoui.
来源: N Engl J Med. 2025年393卷16期1589-1598页
Misdiagnosis or underdiagnosis of rare diseases in patients with diagnoses of common diseases can lead to delayed or inappropriate treatments, thereby complicating the management of both rare and common conditions. Despite advances in molecular diagnostic techniques, the effect of rare diseases on the diagnosis of common diseases in research and clinical trials has not been comprehensively investigated.
659. Sacituzumab Govitecan in Untreated, Advanced Triple-Negative Breast Cancer.
作者: Javier Cortés.;Kevin Punie.;Carlos Barrios.;Sara A Hurvitz.;Andreas Schneeweiss.;Joohyuk Sohn.;Eriko Tokunaga.;Adam Brufsky.;Yeon Hee Park.;Binghe Xu.;Roberto Hegg.;Mafalda Oliveira.;Alessandra Fabi.;Natalya Vaksman.;Theresa Valdez.;Xinrui Zhang.;Catherine Lai.;Sara M Tolaney.; .
来源: N Engl J Med. 2025年393卷19期1912-1925页
Patients with previously untreated, locally advanced, unresectable or metastatic triple-negative breast cancer who are not candidates for inhibitors of programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1) have limited treatment options.
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