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6561. Neoplasm Reports in Food and Drug Administration Adverse Event Reporting System Following Angiotensin Receptor Blocker Recalls.
作者: Robert Cohen Sedgh.;Jungyeon Moon.;Cynthia A Jackevicius.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷8期e007476页
A worldwide voluntary recall of valsartan in July 2018 due to the potential carcinogen N-nitrosodimethylamine received extensive media and public attention. This was followed by more Food and Drug Administration (FDA) recalls regarding other contaminated ARB (angiotensin receptor blocker) products. Our study investigated the association between the FDA recalls and ARB neoplasm adverse events (AEs) reported to the FDA adverse event reporting system.
6562. Hemodynamic Consequences of an Undersized Extracardiac Conduit in an Adult Fontan Patient Revealed by 4-Dimensional Flow Magnetic Resonance Imaging.
作者: Friso M Rijnberg.;Hans C van Assen.;Mark G Hazekamp.;Arno A W Roest.;Jos J M Westenberg.
来源: Circ Cardiovasc Imaging. 2021年14卷8期e012612页 6563. Transient Complete Atrioventricular Block due to Rupture of the Right Sinus of Valsalva.
作者: Pier Paolo Bocchino.;Renata Fasano.;Federico Fortuni.;Luca Franchin.;Matteo Bellettini.;Gianluca Alunni.;Gaetano Maria De Ferrari.
来源: Circ Cardiovasc Imaging. 2021年14卷8期e012708页 6564. Effect of Rivaroxaban and Aspirin in Patients With Peripheral Artery Disease Undergoing Surgical Revascularization: Insights From the VOYAGER PAD Trial.
作者: E Sebastian Debus.;Mark R Nehler.;Nicholas Govsyeyev.;Rupert M Bauersachs.;Sonia S Anand.;Manesh R Patel.;Fabrizio Fanelli.;Warren H Capell.;Taylor Brackin.;Franz Hinterreiter.;Dainis Krievins.;Patrice Nault.;Gabriele Piffaretti.;Alexei Svetlikov.;Nicole Jaeger.;Connie N Hess.;Henrik H Sillesen.;Michael Conte.;Joseph Mills.;Eva Muehlhofer.;Lloyd P Haskell.;Scott D Berkowitz.;William R Hiatt.;Marc P Bonaca.
来源: Circulation. 2021年144卷14期1104-1116页
Patients with peripheral artery disease requiring lower extremity revascularization (LER) are at high risk of adverse limb and cardiovascular events. The VOYAGER PAD trial (Vascular Outcomes Study of ASA [Acetylsalicylic Acid] Along With Rivaroxaban in Endovascular or Surgical Limb Revascularization for PAD) demonstrated that rivaroxaban significantly reduced this risk. The efficacy and safety of rivaroxaban has not been described in patients who underwent surgical LER.
6565. Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm.
作者: Pedro Lopez-Ayala.;Thomas Nestelberger.;Jasper Boeddinghaus.;Luca Koechlin.;Paul David Ratmann.;Ivo Strebel.;Juliane Gehrke.;Severin Meier.;Joan Walter.;Maria Rubini Gimenez.;Eugenio Mutschler.;Òscar Miró.;Beatriz López-Barbeito.;Francisco Javier Martín-Sánchez.;Esther Rodríguez-Adrada.;Dagmar I Keller.;L Kristin Newby.;Raphael Twerenbold.;Evangelos Giannitsis.;Bertil Lindahl.;Christian Mueller.; .
来源: Circulation. 2021年144卷10期773-787页
The non-ST-segment-elevation myocardial infarction (NSTEMI) guidelines of the European Society of Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to the observe-zone of the ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, a specific cutoff for 0/3h high-sensitivity cardiac troponin T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation.
6566. Prognostication of Asymptomatic Penetrating Aortic Ulcers: A Modern Approach.
作者: Charles DeCarlo.;Christopher A Latz.;Laura T Boitano.;Young Kim.;Adam Tanious.;Samuel I Schwartz.;Rushad Patell.;Jahan Mohebali.;Anahita Dua.
来源: Circulation. 2021年144卷14期1091-1101页
Literature detailing the natural history of asymptomatic penetrating aortic ulcers (PAUs) is sparse and lacks long-term follow-up. This study sought to determine the rate of asymptomatic PAU growth over time and adverse events from asymptomatic PAU.
6567. Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair.
作者: Andreas J Rieth.;Steffen D Kriechbaum.;Manuel J Richter.;Elena Wenninger.;Ulrich Fischer-Rasokat.;Khodr Tello.;Henning Gall.;Hossein A Ghofrani.;Stefan Guth.;Christoph B Wiedenroth.;Veselin Mitrovic.;Christian W Hamm.;Christoph Liebetrau.;Claudia Walther.
来源: Circ Cardiovasc Interv. 2021年14卷9期e010453页
[Figure: see text].
6568. NAD+ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy.
作者: Ying Ann Chiao.;Akash Deep Chakraborty.;Christine M Light.;Rong Tian.;Junichi Sadoshima.;Xiaojian Shi.;Haiwei Gu.;Chi Fung Lee.
来源: Circ Heart Fail. 2021年14卷8期e008170页
Diabetes is a risk factor for heart failure and promotes cardiac dysfunction. Diabetic tissues are associated with nicotinamide adenine dinucleotide (NAD+) redox imbalance; however, the hypothesis that NAD+ redox imbalance causes diabetic cardiomyopathy has not been tested. This investigation used mouse models with altered NAD+ redox balance to test this hypothesis.
6569. Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca2+-ATPase Expression in Cardiomyocytes.
作者: Mortimer Korf-Klingebiel.;Marc R Reboll.;Felix Polten.;Natalie Weber.;Felix Jäckle.;Xuekun Wu.;Marinos Kallikourdis.;Paolo Kunderfranco.;Gianluigi Condorelli.;Evangelos Giannitsis.;Olga S Kustikova.;Axel Schambach.;Andreas Pich.;Julian D Widder.;Johann Bauersachs.;Joop van den Heuvel.;Theresia Kraft.;Yong Wang.;Kai C Wollert.
来源: Circulation. 2021年144卷15期1227-1240页
Inflammation contributes to the pathogenesis of heart failure, but there is limited understanding of inflammation's potential benefits. Inflammatory cells secrete MYDGF (myeloid-derived growth factor) to promote tissue repair after acute myocardial infarction. We hypothesized that MYDGF has a role in cardiac adaptation to persistent pressure overload.
6570. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease: An National Cardiovascular Data Registry Research to Practice Project.
作者: Eric A Secemsky.;Neel Butala.;Aishwarya Raja.;Rohan Khera.;Yongfei Wang.;Jeptha P Curtis.;Thomas M Maddox.;Salim S Virani.;Ehrin J Armstrong.;Kendrick A Shunk.;Ralph G Brindis.;Deepak Bhatt.;Robert W Yeh.
来源: Circ Cardiovasc Interv. 2021年14卷8期e010323页
[Figure: see text].
6572. Long-Term Trajectories of Left Ventricular Ejection Fraction in Patients With Chronic Inflammatory Diseases and Heart Failure: An Analysis of Electronic Health Records.
作者: Adovich S Rivera.;Arjun Sinha.;Faraz S Ahmad.;Edward Thorp.;Jane E Wilcox.;Donald M Lloyd-Jones.;Matthew J Feinstein.
来源: Circ Heart Fail. 2021年14卷8期e008478页
Immune regulation and inflammation play a role in the pathogenesis and progression of acute and chronic heart failure (HF). Although the clinical course of acute, severe inflammatory cardiomyopathy is well described, the effects of chronic systemic inflammation on cardiovascular function over time are less clear. To investigate this question, we compared trajectories over time in left ventricular ejection fraction for patients with HF with different chronic inflammatory diseases (CIDs): HIV, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, inflammatory bowel disease, and/or psoriasis.
6575. Response by Brunham et al to Letter Regarding Article, "Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis".6576. Letter by Quintão and Cazita Regarding Article, "Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis".6580. Safety and Effectiveness of the SVELTE Fixed-Wire and Rapid Exchange Bioresorbable-Polymer Sirolimus-Eluting Coronary Stent Systems for the Treatment of Atherosclerotic Lesions: Results of the OPTIMIZE Randomized Study.
作者: Dean J Kereiakes.;Robert L Feldman.;A J J Ijsselmuiden.;Shigeru Saito.;Giovanni Amoroso.;James P Zidar.;S Chiu Wong.;Pieter Stella.;Steven Yakubov.;John Lasala.;David J Cohen.;Gheorghe Doros.;Donald E Cutlip.;Sunil V Rao.
来源: Circ Cardiovasc Interv. 2021年14卷9期e010609页
[Figure: see text].
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