6359. Teclistamab, a B-cell maturation antigen × CD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MajesTEC-1): a multicentre, open-label, single-arm, phase 1 study.
作者: Saad Z Usmani.;Alfred L Garfall.;Niels W C J van de Donk.;Hareth Nahi.;Jesus F San-Miguel.;Albert Oriol.;Laura Rosinol.;Ajai Chari.;Manisha Bhutani.;Lionel Karlin.;Lotfi Benboubker.;Lixia Pei.;Raluca Verona.;Suzette Girgis.;Tara Stephenson.;Yusri Elsayed.;Jeffrey Infante.;Jenna D Goldberg.;Arnob Banerjee.;María-Victoria Mateos.;Amrita Krishnan.
来源: Lancet. 2021年398卷10301期665-674页
There is a need for novel therapies for relapsed or refractory multiple myeloma, and B-cell maturation antigen (BCMA) is a validated target. Teclistamab is a bispecific antibody that binds BCMA and CD3 to redirect T cells to multiple myeloma cells. The aim of the MajesTEC-1 study was to evaluate the safety, tolerability, and preliminary efficacy of teclistamab in patients with relapsed or refractory multiple myeloma.
6360. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.
作者: Ly-Mee Yu.;Mona Bafadhel.;Jienchi Dorward.;Gail Hayward.;Benjamin R Saville.;Oghenekome Gbinigie.;Oliver Van Hecke.;Emma Ogburn.;Philip H Evans.;Nicholas P B Thomas.;Mahendra G Patel.;Duncan Richards.;Nicholas Berry.;Michelle A Detry.;Christina Saunders.;Mark Fitzgerald.;Victoria Harris.;Milensu Shanyinde.;Simon de Lusignan.;Monique I Andersson.;Peter J Barnes.;Richard E K Russell.;Dan V Nicolau.;Sanjay Ramakrishnan.;F D Richard Hobbs.;Christopher C Butler.; .
来源: Lancet. 2021年398卷10303期843-855页
A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown. We aimed to establish whether inhaled budesonide reduces time to recovery and COVID-19-related hospital admissions or deaths among people at high risk of complications in the community.
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