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607. TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial.
作者: Elvin Kedhi.;Renicus S Hermanides.;Jan-Henk E Dambrink.;Sandeep K Singh.;Jurriën M Ten Berg.;DirkJan van Ginkel.;Martin Hudec.;Giovanni Amoroso.;Ignacio J Amat-Santos.;Martin Andreas.;Rui Campante Teles.;Guillaume Bonnet.;Eric Van Belle.;Lenard Conradi.;Leen van Garsse.;Wojtek Wojakowski.;Vassilis Voudris.;Jerzy Sacha.;Pavel Cervinka.;Erik Lipsic.;Samer Somi.;Luis Nombela-Franco.;Sonja Postma.;Kerstin Piayda.;Giuseppe De Luca.;Evelien Kolkman.;Krzysztof P Malinowski.;Thomas Modine.; .
来源: Lancet. 2025年404卷10471期2593-2602页
Patients with severe aortic stenosis present frequently (∼50%) with concomitant obstructive coronary artery disease. Current guidelines recommend combined surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG) as the preferred treatment. Transcatheter aortic valve implantation (TAVI) and fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) represent a valid treatment alternative. We aimed to test the non-inferiority of FFR-guided PCI plus TAVI versus SAVR plus CABG in patients with severe aortic stenosis and complex coronary artery disease.
611. Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials.
作者: Paula Río.;Josune Zubicaray.;Susana Navarro.;Eva Gálvez.;Rebeca Sánchez-Domínguez.;Eileen Nicoletti.;Elena Sebastián.;Michael Rothe.;Roser Pujol.;Massimo Bogliolo.;Philipp John-Neek.;Antonella Lucía Bastone.;Axel Schambach.;Wei Wang.;Manfred Schmidt.;Lise Larcher.;José C Segovia.;Rosa M Yáñez.;Omaira Alberquilla.;Begoña Díez.;María Fernández-García.;Laura García-García.;Manuel Ramírez.;Anne Galy.;Francois Lefrere.;Marina Cavazzana.;Thierry Leblanc.;Nagore García de Andoin.;Ricardo López-Almaraz.;Albert Catalá.;Jordi Barquinero.;Sandra Rodríguez-Perales.;Gayatri Rao.;Jordi Surrallés.;Jean Soulier.;Cristina Díaz-de-Heredia.;Jonathan D Schwartz.;Julián Sevilla.;Juan A Bueren.; .
来源: Lancet. 2025年404卷10471期2584-2592页
Allogeneic haematopoietic stem-cell transplantation is the standard treatment for bone marrow failure (BMF) in patients with Fanconi anaemia, but transplantation-associated complications such as an increased incidence of subsequent cancer are frequent. The aim of this study was to evaluate the safety and efficacy of the infusion of autologous gene-corrected haematopoietic stem cells as an alternative therapy for these patients.
615. Violence against women and girls in conflict: progress and priorities.
作者: Maureen Murphy.;Alina Potts.;Gabriella Nassif.;Limiaa Abdelgafar Khalfalla.;Jihan Kaisi.;Anny T Modi.;Emanuela Paul.;Sheuly Sharma.;Anna Tazita Samuel.;Mary Ellsberg.
来源: Lancet. 2025年404卷10471期2495-2498页 |