526. Integrating environmental outcomes in randomised clinical trials: a call to action.
作者: Johanne Juul Petersen.;Linn Hemberg.;Lehana Thabane.;Sally Hopewell.;An-Wen Chan.;Asbjørn Hróbjartsson.;Ole Mathiesen.;Myles Sergeant.;Sujane Kandasamy.;Nandi Siegfried.;Paula R Williamson.;Lisa Fox.;Caroline Barkholt Kamp.;Jean-Marc Hoffmann.;Stig Brorson.;Peter Bentzer.;Janus Christian Jakobsen.
来源: Lancet. 2025年405卷10477期446-448页 530. Effect of a spatial repellent on malaria incidence in an area of western Kenya characterised by high malaria transmission, insecticide resistance, and universal coverage of insecticide treated nets (part of the AEGIS Consortium): a cluster-randomised, controlled trial.
作者: Eric O Ochomo.;John E Gimnig.;Quentin Awori.;Bernard Abong'o.;Prisca Oria.;Nickline K Ashitiba.;Brian Polo.;Vincent Moshi.;Hilda Otanga.;Ferdinard Adung'o.;Eunice A Ouma.;Susan Outa.;Edith Ramaita.;Rebecca Levine.;Wycliffe Odongo.;Steven A Harvey.;April Monroe.;Ashley Hudson.;Bradley Sandberg.;Jared Hendrickson.;Xingyuan Zhao.;Ruyu Zhou.;Fang Liu.;Nicole L Achee.;John P Grieco.
来源: Lancet. 2025年405卷10473期147-156页
Spatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human-vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial repellent epidemiological efficacy against Aedes-borne viruses but inconclusive outcomes against malaria. We aimed to show and quantify the protective efficacy of spatial repellents in reducing malaria infection incidence in Busia County, Kenya.
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