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501. Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Patients With Obesity-Related Heart Failure With Preserved Ejection Fraction: The UFA-Preserved2 Randomized Controlled Crossover Study.
作者: Salvatore Carbone.;Hayley E Billingsley.;Syed Imran Ahmed.;Michele Golino.;Benjamin W Van Tassell.;Roshanak Markley.;Danielle L Kirkman.;Ross Arena.;Carl J Lavie.;Antonio Abbate.
来源: Circ Heart Fail. 2026年19卷2期e013511页 502. Blood Volume Expansion: Can an Adaptation of Endurance Training, Altitude Acclimatization, and Pregnancy Inform Volume Homeostasis in Chronic Heart Failure and Why Does It Matter? A Viewpoint.503. Convolutional Neural Network Models Leverage Morphological Rather Than Temporal Features to Detect Myocardial Diseases From 12-Lead Electrocardiograms.
作者: Masamitsu Nakayama.;Ryuichiro Yagi.;Yoshinori Katsumata.;Masayuki Oki.;Rahul C Deo.;Calum A MacRae.;Shinichi Goto.
来源: Circ Arrhythm Electrophysiol. 2026年19卷1期e014369页 504. Resolution of Systemic Inflammation in Patients With Recently Decompensated Heart Failure With Reduced Ejection Fraction With and Without Interleukin-1 Blockade by Anakinra.
作者: Benjamin W Van Tassell.;Michele Golino.;Justin M Canada.;Roshanak Markley.;Hayley Billingsley.;Marco Giuseppe Del Buono.;Azita Talasaz.;Georgia Thomas.;Juan Guido Chiabrando.;George Wohlford.;Virginia Dickson.;Dinesh Kadariya.;Juan Ignacio Damonte.;Ai-Chen Jane Ho.;Yub Raj Sedhai.;Emily Kontos.;Alessandra Vecchiè.;Joshua D West.;Giuliana Corna.;Horacio Medina de Chazal.;Sebastian Pinel.;Edoardo Bressi.;Andrew Barron.;Megan Dell.;James Mbualungu.;Francesco Moroni.;Jeremy Turlington.;Emily Federmann.;Cory R Trankle.;Salvatore Carbone.;Ross Arena.;Antonio Abbate.
来源: Circ Heart Fail. 2026年19卷3期e013546页
Decompensated heart failure with reduced ejection fraction (HFrEF) is associated with systemic inflammation that predicts unfavorable outcomes. We aimed to determine whether anakinra, an IL-1 (interleukin-1) blocker, favors inflammation resolution (CRP [C-reactive protein]) and improves peak oxygen consumption (VO2) in patients with recently decompensated HFrEF.
505. Real-Time Biventricular Pressure-Volume Loops During Percutaneous Pulmonary Valve Implantation in Patients With RVOT Dysfunction.
作者: Heiner Latus.;Verena Schindler.;Julie Cleuziou.;Markus Khalil.;Christian Jux.;Christian Meierhofer.;Daniel Tanase.;Andreas Eicken.;Peter Ewert.;Stanimir Georgiev.
来源: Circ Heart Fail. 2026年19卷2期e013235页
In patients with right ventricular (RV) outflow tract stenosis and pulmonary regurgitation (PR), percutaneous pulmonary valve implantation (PPVI) aims to preserve RV and left ventricular (LV) integrity and function. Our study aimed to assess acute changes in biventricular intrinsic myocardial function occurring with PPVI.
507. Letter by Hang et al Regarding Article, "An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress".508. Response by Balligand and Michel to Letter Regarding Article, "An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress".509. A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.
作者: Russell Stewart.;Brandon D Lowery.;Eric Farber-Eger.;Yuko Wada.;Dan M Roden.;Quinn S Wells.;Giovanni Davogustto.
来源: Circulation. 2025年152卷25期1806-1808页 514. Athlete's Heart or Heart at Risk? Cardiac Remodeling and Exercise-Induced Ventricular Arrhythmias in Elite Athletes.
作者: Giuseppe Di Gioia.;Maria Rosaria Squeo.;Armando Ferrera.;Francesco Raffaele Spera.;Viviana Maestrini.;Sara Monosilio.;Federica Mango.;Giulia Paoletti.;Andrea Serdoz.;Marco Bernardi.;Antonio Pelliccia.
来源: Circ Arrhythm Electrophysiol. 2026年19卷1期e014143页
Ventricular ectopic beats (VEBs) are frequently observed in athletes, but their clinical significance remains debated. We aimed to assess the prevalence, pattern of exercise-induced VEBs, and their association with exercise-induced cardiac remodeling (EICR) in elite athletes.
515. Percutaneous Patent Foramen Ovale Closure During ProtekDuo Support and Transcatheter Tricuspid Repair After Left Ventricular Assist Device Implantation: While the Right Ventricle Gives Up, Cardiologists Don't.
作者: Marco Tomasino.;Sofía Vila-Sanjuán.;Eduard Ródenas-Alesina.;Toni Soriano-Colomé.;Laia Milà.;Javier Solsona-Caravaca.;Gerard Martí-Aguasca.;Ignacio Ferreira-González.;Aitor Uribarri.
来源: Circ Heart Fail. 2026年19卷2期e013354页 517. 2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
作者: .;Michelle Gurvitz.;Eric V Krieger.;Stephanie Fuller.;Leslie L Davis.;Michelle M Kittleson.;Jamil A Aboulhosn.;Elisa A Bradley.;Jonathan Buber.;Curt J Daniels.;Konstantinos Dimopoulos.;Alexander Egbe.;Tracy R Geoffrion.;Anitha John.;Paul Khairy.;Yuli Y Kim.;Jacqueline Kreutzer.;Matthew J Lewis.;Jonathan N Menachem.;Jeremy P Moore.;Kathryn A Osteen.;Puja B Parikh.;Arwa Saidi.;Katherine B Salciccioli.;Rachel L Schunder.;Anne Marie Valente.;Rachel M Wald.
来源: Circulation. 2026年153卷8期e115-e251页
The "2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease" provides recommendations to guide clinicians on the evaluation and treatment of adult patients with congenital heart disease. It incorporates new evidence to replace the "2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease."
519. Bradycardia in Athletes: Prevalence, Mechanisms, and Risks.
作者: Paolo D'Ambrosio.;Jarne De Paepe.;Luke W Spencer.;Monique Ohanian.;Kristel Janssens.;Amy M Mitchell.;M Darragh Flannery.;Youri Bekhuis.;Rik Pauwels.;Boris Delpire.;Christophe Dausin.;Stephanie J Rowe.;Tim Van Puyvelde.;Paul E Young.;Magdalena J Soka.;Renee Johnson.;Chenglong Yu.;Gwilym M Morris.;Tomas Robyns.;Paul Lacaze.;Eleni Giannoulatou.;Peter M Kistler.;Jonathan M Kalman.;Hein Heidbuchel.;Rik Willems.;Guido Claessen.;Diane Fatkin.;André La Gerche.; .
来源: Circulation. 2026年153卷9期616-630页
Sinus bradycardia is a well-recognized physiological adaptation in endurance athletes, primarily attributed to sinus node remodeling or increased vagal modulation. Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated.
520. Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Formation by Targeting LOX-1.
作者: Jie Zhang.;Liwen Yu.;Wei Yang.;Lei Cao.;Xiaohong Wang.;Chunyu Kao.;Zijing Li.;Ruiqing Ren.;Wenqian Qi.;Lijuan Lyu.;Wenjing Xiong.;Wenhai Sui.;Xiao Wu.;Na Li.;Bingjie Liu.;Shasha Wang.;Peili Bu.;Yun Zhang.;Chengjiang Gao.;Cheng Zhang.;Meng Zhang.
来源: Circulation. 2026年153卷8期576-596页
Atherosclerosis is a chronic inflammatory disease marked by lipid accumulation and immune cell infiltration in arterial walls. Macrophages contribute by internalizing oxidized low-density lipoprotein, forming foam cells, and driving inflammation. The ubiquitin-proteasome system regulates immune and inflammatory responses in atherosclerosis. This study investigated the protective role of TRIM31 (tripartite motif-containing 31), an E3 ubiquitin ligase, in macrophage lipid metabolism and inflammation through selective regulation of LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1).
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