Percutaneous coronary intervention outcomes rely heavily on accurate lesion assessment and procedural planning. Invasive tools, such as fractional flow reserve, nonhyperemic pressure ratios, intravascular ultrasound, and optical coherence tomography, provide essential physiological and anatomic insights but are resource-intensive, prolong procedures, and increase contrast and radiation exposure. Coronary computed tomography (CT) angiography has emerged as a noninvasive modality with high diagnostic accuracy for coronary artery disease, capable of detailing plaque composition, lesion length, and vessel geometry. With the integration of CT-derived fractional flow reserve and CT myocardial perfusion imaging, coronary CT angiography now offers both anatomic and functional evaluation, bridging diagnostic and interventional decision-making. Despite guideline endorsement for coronary artery disease diagnosis, its role in guiding percutaneous coronary intervention strategies remains underutilized and absent from revascularization recommendations. This review outlines a practical, step-by-step framework for integrating coronary CT angiography into contemporary percutaneous coronary intervention planning, covering acquisition protocols, software platforms, lesion assessment, and stent strategy optimization. It also explores emerging intraprocedural applications, including fusion imaging, augmented and virtual reality, and holographic visualization. By synthesizing current evidence and identifying gaps, this review positions coronary CT angiography as a promising adjunct in precision-based percutaneous coronary intervention.

This study aims to develop a diffusion model-based framework for generating late gadolinium enhancement (LGE)-like images without contrast. The resulting synthetic images are then comprehensively evaluated for subjective and objective image quality, as well as their clinical utility for quantifying scar in acute myocardial infarction.

Despite the rise of pulsed-field ablation (PFA), predicting and titrating lesion geometry remains challenging. This study aimed to find modifiable parameters that can accurately and repeatedly predict focal PFA lesions across a range of dimensions and to develop a model to predict lesion geometry.

Conventional atrial pacing at the right atrial appendage may impair interatrial synchrony. Posterosuperior bundle (PSB) pacing has been observed to offer anatomic accessibility by targeting the interatrial muscular connection within the superior vena cava. The study aimed to further validate the feasibility of PSB pacing and to observe mid-term outcomes through a retrospective cohort analysis.

GLP-1 (glucagon-like peptide-1) receptor agonists (GLP-1RAs), initially developed for glycemic control in type 2 diabetes, have shown cardiometabolic benefits including weight loss, improved endothelial function, and reduced inflammation. Recent data suggest potential anti-arrhythmic effects via modulation of atrial substrate and autonomic tone. Their impact on obese, nondiabetic patients remains underexplored. This study examines whether GLP-1RA use is associated with reduced atrial fibrillation recurrence after catheter ablation in obese patients, using real-world data from a large multicenter database.

Suboptimal left ventricular (LV) and right ventricular lead positioning has been associated with a lesser response to cardiac resynchronization therapy. The MAPIT-CRT (MRI Allocation of Pacing Targets in Cardiac Resynchronization Therapy) randomized controlled trial evaluated a novel, cardiac magnetic resonance-generated 4-dimensional phenomics cardiac magnetic resonance imaging (4DPcmr) lead placement strategy.

Apolipoprotein B (apoB) is essential for lipoprotein assembly and secretion and plays a central role in the development of cardiovascular disease and metabolic dysfunction-associated steatotic liver disease. Although apoB protein degradation during very-low-density lipoprotein maturation has been extensively studied, the regulation of Apob mRNA stability under physiological and pathological conditions remains unexplored.

Cardiac radioablation is emerging as a treatment modality for refractory ventricular tachycardia. This study aimed to evaluate the effects of radiation on the coronary arteries in a swine model of proton beam cardiac radioablation.

Decompensated heart failure with reduced ejection fraction (HFrEF) is associated with systemic inflammation that predicts unfavorable outcomes. We aimed to determine whether anakinra, an IL-1 (interleukin-1) blocker, favors inflammation resolution (CRP [C-reactive protein]) and improves peak oxygen consumption (VO2) in patients with recently decompensated HFrEF.

In patients with right ventricular (RV) outflow tract stenosis and pulmonary regurgitation (PR), percutaneous pulmonary valve implantation (PPVI) aims to preserve RV and left ventricular (LV) integrity and function. Our study aimed to assess acute changes in biventricular intrinsic myocardial function occurring with PPVI.