This study aims to evaluate the care practices of adult patients with percutaneous endoscopic gastrostomy and the care burden of individuals who provide care for these patients in this regard.

Both insulin resistance and low-grade inflammation contribute to liver disease development, yet their combined predictive role remains unclear at the population level.

This multicenter study evaluated serum HBV RNA as a prognostic biomarker for nucleos(t)ide analogue (NA) therapy in chronic hepatitis B (CHB), focusing on correlations with HBV DNA/HBsAg and predictive value for virological response (VR) and HBeAg seroconversion.

To investigate the incidence of colorectal polyps in patients with chronic hepatitis B (CHB) complicated by non - alcoholic fatty liver disease (NAFLD) and its risk factors.

Dysfunction of the intestinal epithelial barrier, often observed in individuals with depression and Metabolic Syndrome (MetS), may contribute to liver dysfunction and increased cardiovascular risk (CVR). However, hepatic alterations influenced by enteric dysfunction in individuals with depression remain insufficiently investigated. The aim of the study is to investigate the associations between the non-invasive indices of hepatic steatosis and fibrosis and intestinal dysfunction biomarkers in patients with depressive disorders, taking into account the presence of MetS or its components, as well as dietary, behavioral and psychosocial factors, and antidepressant intake status.

Sub-Saharan African countries remain adversely affected by the burden of liver cirrhosis, recording the highest age-standardized death rates in the world. Hospital admission represents a measurable proxy of the burden of cirrhosis, driving up healthcare costs and imposing a burden on patients and caretakers. This study was set out to fill a local gap in knowledge of the rate and predictors of readmission among patients with decompensated cirrhosis which is crucial in order to reduce it.

Methotrexate (MTX) is a commonly used drug to treat various cancers and autoimmune disorders, but its clinical utility is often limited by hepatotoxicity. β-sitosterol is a bioactive phytosterol compound that is naturally present in various plant foods and exhibits multiple antioxidant, anticancer and immunomodulatory activities. It has not been fully explored for its potential protective effects against liver injury. This study investigated whether β-sitosterol is associated with reduced hepatic injury in a short-term MTX model.

Postoperative peritoneal adhesion (PA), a prevalent complication of abdominal surgery, arises from aberrant healing of the injured peritoneum. This process involves mesothelial cell trans-differentiation into myofibroblast-like cells, driving peritoneal matrix remodeling and pathological fibrous band formation between organs. Existing therapeutic strategies to prevent PA exhibit limited efficacy, underscoring the need for previously unrecognized mechanistic insights into PA pathogenesis. Here, we elucidate the role of autophagy in mesothelial cell transition and PA development. Utilizing a murine PA model coupled with comprehensive in vitro analyses, we demonstrate that HMGB1-mediated autophagy facilitates TGF-β mediated mesothelial cell trans-differentiation. Specifically, autophagic degradation of E-cadherin counteracts TGF-β-driven mesothelial transition. Pharmacological activation of autophagy via rapamycin or recombinant HMGB1 potentiated this transition, whereas HMGB1 inhibitor (glycyrrhizin) or autophagy suppressor (spautin-1) markedly attenuated it. Crucially, early postoperative administration of glycyrrhizin or spautin-1 significantly reduced PA severity. Our findings unveil autophagy and HMGB1 as pivotal regulator targets of mesothelial plasticity during PA formation, provide mechanistic insights into peritoneum repair, and propose novel therapeutic avenues for PA prevention.

The brain’s response to intestinal inflammation in Crohn’s disease (CD) remains poorly characterized. We aimed to identify a neuroimaging signature of disease activity by integrating structural and functional brain metrics with machine learning.

Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. Clinical studies of IBD robustly show elevated interleukin 1β (IL-1β) levels in intestinal tissue, implicating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which controls IL-1β secretion in myeloid cells. In this study, we aimed to ground potential NLRP3 involvement in IBD in molecular evidence from human studies.

This study aimed to assess the prognostic significance of serum lipoprotein(a) [Lp(a)] levels regarding overall survival (OS) and progression-free survival (PFS) among patients diagnosed with pancreatic cancer (PC).

Cancer treatment is a major concern of health worldwide. Nowadays, colorectal cancer is one of the most prevalent diseases throughout the globe. Therefore, novel cancer treatment modalities are required to stop cancer. Thus, this paper aims to develop a novel drug delivery system (DDS) based on Chitosan (CS), polyamidoamine (PAMAM G4), and Nanoparticles (NP) for efficient delivery of sodium butyrate (NB) and Fe2O3 to SW480 colorectal cancer cells.

This study aimed to investigate the prevalence of gallstone disease among health check-upers (employees) in the Qinghai-Tibet Plateau and clarify the independent effects of altitude, ethnicity, and their interaction on gallstone disease risk, so as to provide evidence for precise prevention and control of gallstone disease in high-altitude multi-ethnic regions.

Assessing quality indicators in colorectal cancer (CRC) screening via the fecal immunochemical test (FIT) is crucial. However, data on developing countries with lower CRC rates, lifestyle transitions, newly established screening programs, and no consensus on optimal targets are scarce.

The safety of morphine in acute pancreatitis (AP) remains controversial due to theoretical risks of exacerbating complications. This study evaluated whether early morphine use correlates with clinical deterioration in AP.

Colorectal cancer (CRC) incidence in Ghana has increased significantly in recent years. Despite medical advances, survival rates remain low, with challenges in CRC screening implementation contributing to late-stage diagnoses and poor outcomes.