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3781. Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
作者: Bin Zhang.;Shuyi Liu.;Tan Tan.;Wenhui Huang.;Yuhao Dong.;Luyan Chen.;Qiuying Chen.;Lu Zhang.;Qingyang Zhong.;Xiaoping Zhang.;Yujian Zou.;Shuixing Zhang.
来源: Chest. 2020年158卷1期e9-e13页
As of March 24, 2020, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for 379,661 infection cases with 16,428 deaths globally, and the number is still increasing rapidly. Herein, we present four critically ill patients with SARS-CoV-2 infection who received supportive care and convalescent plasma. Although all four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy.
3783. Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock: A Randomized Controlled Trial.
作者: Ping Chang.;Yuping Liao.;Jianbin Guan.;Yuexun Guo.;Ming Zhao.;Jianmin Hu.;Jian Zhou.;Hua Wang.;Zhongran Cen.;Ying Tang.;Zhanguo Liu.
来源: Chest. 2020年158卷1期174-182页
Whether hydrocortisone, vitamin C, and thiamine treatment can reduce the mortality of patients with sepsis is controversial.
3784. Echocardiography-Derived Stroke Volume Index Is Associated With Adverse In-Hospital Outcomes in Intermediate-Risk Acute Pulmonary Embolism: A Retrospective Cohort Study.
作者: Graeme Prosperi-Porta.;Kevin Solverson.;Nowell Fine.;Christopher J Humphreys.;André Ferland.;Jason Weatherald.
来源: Chest. 2020年158卷3期1132-1142页
There remains uncertainty in the optimal prognostication and management of patients with intermediate-risk pulmonary embolism (PE). Transthoracic echocardiography can identify right ventricular dysfunction to recognize intermediate-high-risk patients.
3785. Long-Term Noninvasive Ventilation in the Geneva Lake Area: Indications, Prevalence, and Modalities.
作者: Chloé Cantero.;Dan Adler.;Patrick Pasquina.;Christophe Uldry.;Bernard Egger.;Maura Prella.;Alain B Younossian.;Paola M Soccal.;Jean-Louis Pépin.;Jean-Paul Janssens.
来源: Chest. 2020年158卷1期279-291页
Noninvasive ventilation (NIV) is standard of care for chronic hypercapnic respiratory failure, but indications, devices, and ventilatory modes are in constant evolution.
3786. Effectiveness and Safety of Supervised Home-Based Physical Training in Patients With COPD on Long-term Home Oxygen Therapy: A Randomized Trial.
作者: Demetria Kovelis.;Anna R S Gomes.;Camila Mazzarin.;Samia K Biazim.;Fabio Pitta.;Silvia Valderramas.
来源: Chest. 2020年158卷3期965-972页
Patients with COPD in advanced stages who need long-term home oxygen therapy (LTHOT) have difficulty participating in outpatient pulmonary rehabilitation (PR) programs. This difficulty is due to the severity of their disease, limitations involving transportation and mobility, high costs, and issues related to patients' safety and individual needs. Unsupervised home-based physical training (PT) is frequently used.
3787. The Association of ICU Acuity With Adherence to ICU Evidence-Based Processes of Care.
作者: Kelly C Vranas.;Jennifer Y Scott.;Omar Badawi.;Michael O Harhay.;Christopher G Slatore.;Donald R Sullivan.;Meeta Prasad Kerlin.
来源: Chest. 2020年158卷2期579-587页
Admission to high-acuity ICUs has been associated with improved outcomes compared with outcomes in low-acuity ICUs, although the mechanism for these findings is unclear.
3788. Place of Death for Individuals With Chronic Lung Disease: Trends and Associated Factors From 2003 to 2017 in the United States.
作者: Sarah H Cross.;E Wesley Ely.;Dio Kavalieratos.;James A Tulsky.;Haider J Warraich.
来源: Chest. 2020年158卷2期670-680页
Although chronic lung disease is a common cause of mortality, little is known about where individuals with chronic lung disease die.
3790. Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1.
作者: Xiao Tang.;Rong-Hui Du.;Rui Wang.;Tan-Ze Cao.;Lu-Lu Guan.;Cheng-Qing Yang.;Qi Zhu.;Ming Hu.;Xu-Yan Li.;Ying Li.;Li-Rong Liang.;Zhao-Hui Tong.;Bing Sun.;Peng Peng.;Huan-Zhong Shi.
来源: Chest. 2020年158卷1期195-205页
Since the outbreak of coronavirus disease 2019 (COVID-19) in China in December 2019, considerable attention has been focused on its elucidation. However, it is also important for clinicians and epidemiologists to differentiate COVID-19 from other respiratory infectious diseases such as influenza viruses.
3791. OSA and Neurocognitive Impairment in Children With Congenital Heart Disease.
作者: Daniel Combs.;Jamie O Edgin.;Scott Klewer.;Brent J Barber.;Wayne J Morgan.;Chiu-Hsieh Hsu.;Ivo Abraham.;Sairam Parthasarathy.
来源: Chest. 2020年158卷3期1208-1217页
Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of OSA, which is associated with neurocognitive impairment in children without CHD.
3793. Abnormal Pulmonary Lymphatic Flow in Patients With Lymphatic Anomalies and Respiratory Compromise.
作者: Maxim Itkin.;Deborah A Rabinowitz.;Gregory Nadolski.;Patrick Stafler.;Leo Mascarenhas.;Denise Adams.
来源: Chest. 2020年158卷2期681-691页
Pulmonary involvement in lymphatic anomalies (LA) is associated with significant morbidity and mortality. Dynamic contrast-enhanced magnetic resonance lymphangiography (DCMRL) is capable of imaging the lymphatic system in a variety of pulmonary lymphatic disorders.
3794. Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study.
作者: Vincent Ten Cate.;Lisa Eggebrecht.;Andreas Schulz.;Marina Panova-Noeva.;Michael Lenz.;Thomas Koeck.;Steffen Rapp.;Natalie Arnold.;Karl J Lackner.;Stavros Konstantinides.;Christine Espinola-Klein.;Thomas Münzel.;Jürgen H Prochaska.;Philipp S Wild.
来源: Chest. 2020年158卷1期341-349页
Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of VTE.
3795. Randomized Trial on the Effects of High-Dose Zopiclone on OSA Severity, Upper Airway Physiology, and Alertness.
作者: Sophie G Carter.;Jayne C Carberry.;Ronald R Grunstein.;Danny J Eckert.
来源: Chest. 2020年158卷1期374-385页
Studies indicate that standard doses of hypnotics reduce or do not change the apnea-hypopnea index (AHI) or pharyngeal muscle activity. A 1-month trial of nightly zopiclone (7.5 mg) modestly reduced the AHI vs baseline without changing other sleep parameters or next-day sleepiness.
3796. Association Between Participant Contact Attempts and Reports of Being Bothered in a National, Longitudinal Cohort Study of ARDS Survivors.
作者: Michelle N Eakin.;Thomas Eckmann.;Victor D Dinglas.;Ayodele A Akinremi.;Megan Hosey.;Ramona O Hopkins.;Dale M Needham.
来源: Chest. 2020年158卷2期588-595页
Participant retention is a major challenge in clinical research, especially in studies with multiple, longitudinal research assessments. Despite the importance of retention methods, there is little empirical research on how cohort retention efforts are perceived by study participants.
3797. Diagnostic Accuracy of Thoracic Ultrasonography to Differentiate Transudative From Exudative Pleural Effusion.
作者: Boris Shkolnik.;Marc A Judson.;Adam Austin.;Kurt Hu.;Melissa D'Souza.;Alexis Zumbrunn.;John T Huggins.;Recai Yucel.;Amit Chopra.
来源: Chest. 2020年158卷2期692-697页
There are limited data examining the diagnostic accuracy of thoracic ultrasonography (TUS) in distinguishing transudative from exudative pleural effusions.
3798. Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis: The ORANGES Trial.
作者: Jose Iglesias.;Andrew V Vassallo.;Vishal V Patel.;Jesse B Sullivan.;Joseph Cavanaugh.;Yasmine Elbaga.
来源: Chest. 2020年158卷1期164-173页
Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs.
3799. Minimal Clinically Important Differences for Patient-Reported Outcome Measures of Fatigue in Patients With COPD Following Pulmonary Rehabilitation.
作者: Patrícia Rebelo.;Ana Oliveira.;Lília Andrade.;Carla Valente.;Alda Marques.
来源: Chest. 2020年158卷2期550-561页
Fatigue is a burdensome and prevailing symptom in patients with COPD. Pulmonary rehabilitation (PR) improves fatigue; however, interpreting when such improvement is clinically relevant is challenging. Minimal clinically important differences (MCIDs) for instruments assessing fatigue are warranted to better tailor PR and guide clinical decisions.
3800. Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis.
作者: Tuang Yeow Poh.;Pei Yee Tiew.;Albert Yick Hou Lim.;Kai Xian Thng.;Nur A'tikah Binte Mohamed Ali.;Jayanth Kumar Narayana.;Micheál Mac Aogáin.;Zhijun Tien.;Wui Mei Chew.;Adrian Kwok Wai Chan.;Holly R Keir.;Alison J Dicker.;Tidi Maharani Hassan.;Huiying Xu.;Augustine K H Tee.;Thun How Ong.;Mariko Siyue Koh.;John Arputhan Abisheganaden.;James D Chalmers.;Sanjay H Chotirmall.
来源: Chest. 2020年158卷2期512-522页
Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown.
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