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354. Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial.
作者: Giulia Argentesi.;Xilin Wu.;Alexander Ney.;Emily Goodchild.;Kate Laycock.;Yun-Ni Lee.;Russell Senanayake.;James MacFarlane.;Elisabeth Ng.;Jessica Kearney.;Sam O'Toole.;Jackie Salsbury.;Nick Carroll.;Daniel Gillett.;John A Tadross.;Alison Marker.;Edmund M Godfrey.;George Goodchild.;Jonathan P Bestwick.;Mark Gurnell.;Heok Cheow.;Stephen P Pereira.;William M Drake.;Morris J Brown.; .
来源: Lancet. 2025年405卷10479期637-647页
Unilateral aldosterone-producing adrenal adenomas (APAs) are the potentially curable cause of 5% of all cases of hypertension. Their localisation (via adrenal vein sampling [AVS]) and removal (by laparoscopic adrenalectomy) require invasive procedures that are unattractive to patients. Molecular imaging-located, endoscopic ultrasound-guided trans-gastric radiofrequency ablation (EUS-RFA) is a potential novel, minimally invasive alternative to AVS and total adrenalectomy for the treatment of APAs in the left adrenal gland, which is very close to the stomach. We aimed to determine whether EUS-RFA can safely target a heterogeneous set of such tumours without damaging the rest of the adrenal gland or adjacent organs.
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