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2621. The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials.
作者: Kaoru Takase-Minegishi.;Stefan Böhringer.;Jackie L Nam.;Yuko Kaneko.;Frank Behrens.;Saedis Saevarsdottir.;Jacqueline Detert.;Marjatta Leirisalo-Repo.;Désirée van der Heijde.;Robert Landewé.;Sofia Ramiro.;Diane van der Woude.
来源: Rheumatology (Oxford). 2025年64卷2期548-560页
To investigate the efficacy of bDMARDs in patients with RA with RF/ACPA compared with patients without these autoantibodies.
2622. Well-Being Therapy in systemic sclerosis outpatients: a randomized controlled trial.
作者: Sara Romanazzo.;Sara Ceccatelli.;Giovanni Mansueto.;Francesco Sera.;Serena Guiducci.;Marco Matucci Cerinic.;Fiammetta Cosci.
来源: Rheumatology (Oxford). 2025年64卷2期667-674页
Systemic sclerosis (SSc) patients have psychological distress and poor well-being and need a tailored treatment. Psychological interventions, rarely tested for efficacy, showed poor benefits. The present randomized controlled trial tested the efficacy of Well-Being Therapy (WBT) in SSc patients.
2623. Anti-carbamylated protein antibodies drive AEC II toward a profibrotic phenotype by interacting with carbamylated TLR5.
作者: Wei Xu.;Minghua Huang.;Rongrong Dong.;Suyan Yan.;Yan An.;Baocheng Liu.;Zhenzhen Ma.;Kun Mu.;Qingrui Yang.
来源: Rheumatology (Oxford). 2024年63卷10期2874-2886页
This study looked at the role of anti-carbamylated protein (anti-CarP) antibodies in contributing to lung fibrosis in CTD-associated interstitial lung disease (ILD) in an autoantigen-dependent manner.
2624. Follow-up ultrasound examination in patients with newly diagnosed giant cell arteritis.
作者: Valentin S Schäfer.;Christian Dejaco.;Pantelis Karakostas.;Charlotte Behning.;Peter Brossart.;Lara C Burg.
来源: Rheumatology (Oxford). 2025年64卷2期732-739页
Ultrasound is a standard tool to diagnose giant cell arteritis (GCA). Until now, only a few studies have investigated the role of ultrasound in the follow-up of GCA. The aim of this study was to assess the changes in the intima-media thickness (IMT), total number of affected arteries and provisional OMERACT GCA ultrasonography score (OGUS) in a 12-months follow-up period.
2625. Multiple serum biomarkers associate with mortality and interstitial lung disease progression in systemic sclerosis.
作者: Matthew James Sinclair Parker.;Adelle S Jee.;Dylan Hansen.;Susanna Proudman.;Peter Youssef.;Tony J Kenna.;Wendy Stevens.;Mandana Nikpour.;Joanne Sahhar.;Tamera J Corte.
来源: Rheumatology (Oxford). 2024年63卷11期2981-2988页
To investigate the prognostic utility of 28 serum biomarkers in systemic sclerosis (SSc), SSc-associated interstitial lung disease (SSc-ILD) and clinically relevant disease subgroups.
2626. Comparative effectiveness of tofacitinib and tumour necrosis factor inhibitors in patients with rheumatoid arthritis in real-world practice: a prospective observational study.
作者: Soo-Kyung Cho.;Yeo-Jin Song.;Hye Won Kim.;Eunwoo Nam.;Ja-Young Jeon.;Hyun-Jeong Yoo.;Yoon-Kyoung Sung.
来源: Rheumatology (Oxford). 2025年64卷2期541-547页
The objective of this study was to assess the effectiveness of tofacitinib vs TNF inhibitors (TNFis) in Korean patients with RA.
2627. A multiparametric risk table for loss of clinical remission status in patients with rheumatoid arthritis: a STARTER study post-hoc analysis.
作者: Simone Perniola.;Stefano Alivernini.;Elisa Gremese.;Gianpiero Landolfi.;Greta Carrara.;Annamaria Iagnocco.;Carlo Alberto Scirè.
来源: Rheumatology (Oxford). 2025年64卷2期526-532页
This post-hoc analysis was carried out on data acquired in the longitudinal Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission (STARTER) study. Our primary aim was to determine the predictive clinical and musculoskeletal ultrasonographic (MSUS) features associated with disease flare in RA patients in clinical remission, while our secondary aim was to evaluate the probability of disease flare based on clinical and MSUS features.
2631. Disease activity-guided dose optimization including discontinuation of TNF inhibitors in rheumatoid arthritis is effective for up to 10 years: an observational follow-up of the DRESS study.
作者: Céleste J T van der Togt.;Nathan den Broeder.;Marleen S Boonstra.;Aatke van der Maas.;Alfons A den Broeder.;Noortje van Herwaarden.
来源: Rheumatology (Oxford). 2025年64卷2期533-540页
The objective of this study was to investigate the safety and effectiveness of disease activity-guided dose optimization of TNF inhibitors in RA over 10 years.
2634. Association of the clinical components in the distal interphalangeal joint synovio-entheseal complex and subsequent response to ixekizumab or adalimumab in psoriatic arthritis.
作者: Dennis McGonagle.;Arthur Kavanaugh.;Iain B McInnes.;Lars Erik Kristensen.;Joseph F Merola.;Bruce Strober.;Rebecca Bolce.;Jeffrey Lisse.;Jennifer Pustizzi.;Christophe Sapin.;Christopher Ritchlin.
来源: Rheumatology (Oxford). 2024年63卷11期3115-3123页
To assess the frequency of simultaneous distal interphalangeal (DIP) joint disease and adjacent nail psoriasis (finger unit) among patients with psoriatic arthritis (PsA) and compare the efficacy of the IL-17A antagonist ixekizumab (IXE) and the TNF-α inhibitor adalimumab (ADA).
2635. The one-year infection risk among patients diagnosed with giant cell arteritis: use of antibiotics and hospitalisations.
作者: Philip Therkildsen.;Annette de Thurah.;Berit Dalsgaard Nielsen.;Mikkel Faurschou.;Bo Baslund.;Ib Tønder Hansen.;Mette Nørgaard.;Ellen-Margrethe Hauge.
来源: Rheumatology (Oxford). 2025年64卷2期740-746页
Patients with giant cell arteritis (GCA) primarily have their infections managed by primary care providers and hospitalisation is rarely necessary. Existing studies in GCA focus on infection-related hospitalisations only, whereas the use of antibiotic prescriptions is largely unknown. This study aims to examine the one-year overall infection risk among patients with GCA.
2639. Are gout patients with negative dual-energy computed tomography for monosodium urate crystal deposition easy to treat?
作者: Victor Laurent.;Charlotte Jauffret.;Vincent Ducoulombier.;Aurore Pacaud.;Julie Legrand.;Stéphane Verdun.;Laurène Norberciak.;Jean-François Budzik.;Tristan Pascart.
来源: Rheumatology (Oxford). 2025年64卷2期581-587页
To determine the clinical associations and predictive value of two thresholds of negative dual-energy CT (DECT) for MSU crystal deposition in gout patients initiating urate-lowering therapy (ULT) and identify which threshold is more clinically relevant.
2640. Lung imaging patterns in connective tissue disease-associated interstitial lung disease impact prognosis and immunosuppression response.
作者: Boyang Zheng.;Daniel-Costin Marinescu.;Cameron J Hague.;Nestor L Muller.;Darra Murphy.;Andrew Churg.;Joanne L Wright.;Amna Al-Arnawoot.;Ana-Maria Bilawich.;Patrick Bourgouin.;Gerard Cox.;Celine Durand.;Tracy Elliot.;Jennifer Ellis.;Jolene H Fisher.;Derek Fladeland.;Amanda Grant-Orser.;Gillian C Goobie.;Zachary Guenther.;Ehsan Haider.;Nathan Hambly.;James Huynh.;Kerri A Johannson.;Geoffrey Karjala.;Nasreen Khalil.;Martin Kolb.;Jonathon Leipsic.;Stacey D Lok.;Sarah MacIsaac.;Micheal McInnis.;Helene Manganas.;Veronica Marcoux.;John Mayo.;Julie Morisset.;Ciaran Scallan.;Tony Sedlic.;Shane Shapera.;Kelly Sun.;Victoria Tan.;Alyson W Wong.;Christopher J Ryerson.
来源: Rheumatology (Oxford). 2024年63卷10期2734-2740页
Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, and immunosuppression response.
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