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2561. Biomarker analysis from the phase 2b randomized placebo-controlled trial of riociguat in early diffuse cutaneous systemic sclerosis.
作者: Dinesh Khanna.;Frank Kramer.;Josef Höfler.;Mercedeh Ghadessi.;Peter Sandner.;Yannick Allanore.;Christopher P Denton.;Masataka Kuwana.;Marco Matucci-Cerinic.;Janet E Pope.;Tatsuya Atsumi.;Radim Bečvář.;László Czirják.;Ellen De Langhe.;Eric Hachulla.;Tomonori Ishii.;Osamu Ishikawa.;Sindhu R Johnson.;Valeria Riccieri.;Elena Schiopu.;Richard M Silver.;Vanessa Smith.;Chiara Stagnaro.;Virginia Steen.;Wendy Stevens.;Gabriella Szücs.;Marie-Elise Truchetet.;Melanie Wosnitza.;Oliver Distler.
来源: Rheumatology (Oxford). 2024年63卷11期3124-3134页
To examine disease and target engagement biomarkers in the RISE-SSc trial of riociguat in early diffuse cutaneous systemic sclerosis and their potential to predict the response to treatment.
2562. A patient-centred assessment of the 2016 ACR-EULAR Myositis Response Criteria: evaluating the meaningfulness of responses.
作者: Didem Saygin.;Anjana Chandrasekhara Pillai.;Siamak Moghadam-Kia.;Chester V Oddis.;Dianxu Ren.;Catherine Najem.;Harman Dhatt.;Rohit Aggarwal.
来源: Rheumatology (Oxford). 2025年64卷3期1355-1361页
The ACR-EULAR Myositis Response Criteria [Total Improvement Score (TIS)] is a composite measure calculated using changes in myositis core set measures. It is unclear if achieving improvement per TIS reflects improvement in any symptoms of patients with myositis. In this study, we examined the association between achieving TIS improvement and patient-centred outcome measures (PCOMs).
2563. Rheumatoid arthritis and risk of osteoarticular infection and death following Staphylococcus aureus bacteraemia: a nationwide cohort study.
作者: Sabine S Dieperink.;Mette Nørgaard.;Frank Mehnert.;Louise B Oestergaard.;Thomas Benfield.;Christian Torp-Pedersen.;Andreas Petersen.;Bente Glintborg.;Merete L Hetland.
来源: Rheumatology (Oxford). 2024年63卷11期2989-2996页
Osteoarticular infection (OAI) is a feared complication of Staphylococcus aureus bacteraemia (SAB) and is associated with poor outcomes. We aimed to explore the risk of OAI and death following SAB in patients with and without rheumatoid arthritis (RA) and to identify risk factors for OAI in patients with RA.
2565. Comment on: Achieving inactive disease in enthesitis-related arthritis with secukinumab following TNF-inhibitor failure.
作者: Valerio Maniscalco.;Ilaria Pagnini.;Edoardo Marrani.;Ilaria Maccora.;Sarah Abu Rumeileh.;Maria Vincenza Mastrolia.;Gabriele Simonini.
来源: Rheumatology (Oxford). 2024年63卷11期e319-e320页 2567. Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients.
作者: Sahwa Elbagir.;NasrEldeen A Mohammed.;Vilija Oke.;Anders Larsson.;Jan Nilsson.;Amir Elshafie.;Elnour M Elagib.;Musa A M Nur.;Iva Gunnarsson.;Elisabet Svenungsson.;Johan Rönnelid.
来源: Rheumatology (Oxford). 2025年64卷3期1170-1178页
In SLE, anti-dsDNA can co-occur with autoantibodies against other chromatin components, like histones and nucleosomes. These antibodies induce type-1 interferon production, a hallmark of SLE. We measured ANA sub-specificities and investigated their associations to inflammatory biomarkers including interferon-regulated chemokines.
2570. Non-opioid analgesic combinations following total hip arthroplasty (RECIPE): a randomised, placebo-controlled, blinded, multicentre trial.
作者: Joakim Steiness.;Daniel Hägi-Pedersen.;Troels Haxholdt Lunn.;Søren Overgaard.;Stig Brorson.;Ben Kristian Graungaard.;Martin Lindberg-Larsen.;Claus Varnum.;Lars Hyldborg Lundstrøm.;Torben Beck.;Michael Skettrup.;Niels Anker Pedersen.;Manuel Josef Bieder.;Adam Gregers von Cappeln.;Lina Pleckaitiene.;Peter Lindholm.;Syed Shaheer Haider Bukhari.;Cecilie Bauer Derby.;Maria Gantzel Nielsen.;Oskar Wilborg Exsteen.;Louise Ørts Vinstrup.;Kasper Højgaard Thybo.;Kasper Smidt Gasbjerg.;Anders Kehlet Nørskov.;Janus Christian Jakobsen.;Ole Mathiesen.; .
来源: Lancet Rheumatol. 2024年6卷4期e205-e215页
Multimodal postoperative analgesia following total hip arthroplasty is recommended, but the optimal combination of drugs remains uncertain. The aim of the RECIPE trial was to investigate the relative benefit and harm of the different combinations of paracetamol, ibuprofen, and the analgesic adjuvant dexamethasone for treatment of postoperative pain following total hip arthroplasty.
2571. Identification of early risk factors for anti-citrullinated-protein-antibody positive rheumatoid arthritis-a prospective cohort study.
作者: Alexandra Cîrciumaru.;Yogan Kisten.;Monika Hansson.;Linda Mathsson-Alm.;Vijay Joshua.;Heidi Wähämaa.;Malena Loberg Haarhaus.;Joakim Lindqvist.;Leonid Padyukov.;Sergiu-Bogdan Catrina.;Guozhong Fei.;Nancy Vivar.;Hamed Rezaei.;Erik Af Klint.;Aleksandra Antovic.;Bence Réthi.;Anca I Catrina.;Aase Hensvold.
来源: Rheumatology (Oxford). 2024年63卷11期3164-3171页
Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression.
2575. Osteoporosis is associated with anti-topoisomerase I positivity and glucocorticoids use in patients with systemic sclerosis.
作者: Charles Midol.;Edgar Wiebe.;Elise Siegert.;Dörte Huscher.;Hélène Béhal.;David Launay.;Eric Hachulla.;Eric L Matteson.;Frank Buttgereit.;Vincent Sobanski.
来源: Rheumatology (Oxford). 2025年64卷3期1270-1276页
Patients with systemic sclerosis (SSc) are at increased risk for osteoporosis (OP) and associated fragility fractures. This study aimed to identify underlying risk factors for these conditions in patients with SSc.
2576. Cancer risk with tocilizumab/sarilumab, abatacept and rituximab treatment in patients with rheumatoid arthritis: a Danish cohort study.
作者: Rasmus Westermann.;René Lindholm Cordtz.;Kirsten Duch.;Lene Mellemkjaer.;Merete Lund Hetland.;Bergur Magnussen.;Lene Dreyer.
来源: Rheumatology (Oxford). 2025年64卷3期1019-1028页
To investigate cancer risk in RA patients treated with tocilizumab/sarilumab, abatacept or rituximab compared with those who received TNF inhibitors (TNFi) and compared with biological DMARDs (bDMARD)-naïve RA patients.
2579. Bi-directional association of rheumatoid arthritis and chronic obstructive pulmonary disease: linking arthritis, inflammation, smoking, airways disease, and emphysema.2580. Trismus as a new feature of VEXAS syndrome.
作者: Alexis Archambeaud.;Claire Le Dreau.;Adrien Bigot.;Olivier Kosmider.;Assia Taleb.;Lara Boucher.;Marie Temple.;Jean-Philippe Cottier.;François Maillot.;Alexandra Audemard-Verger.
来源: Rheumatology (Oxford). 2024年63卷9期e258-e260页 |