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2341. Human umbilical cord mesenchymal stem cells treated anti-MDA5 antibody-positive dermatomyositis with interstitial lung disease: a case report.
作者: Runlu Zhou.;Xiao Jin.;Juan Li.;Yucong He.;Tianming Gao.;Chenghua Zhu.;Yan Wang.;Ganzhu Feng.
来源: Rheumatology (Oxford). 2025年64卷2期892-894页 2342. Disruption of memory B-cell trafficking by belimumab in patients with systemic lupus erythematosus.
作者: Eline J Arends.;Mihaela Zlei.;Christopher M Tipton.;Jasna Cotic.;Zgjim Osmani.;Fenna J de Bie.;Sylvia W A Kamerling.;Andre van Maurik.;Richard Dimelow.;Yun Irene Gregan.;Norma Lynn Fox.;Ton J Rabelink.;David A Roth.;Ignacio Sanz.;Jacques J M van Dongen.;Cees van Kooten.;Y K Onno Teng.
来源: Rheumatology (Oxford). 2024年63卷9期2387-2398页
Autoreactive memory B cells (MBCs) contribute to chronic and progressive courses in autoimmune diseases like SLE. The efficacy of belimumab (BEL), the first approved biologic treatment for SLE and LN, is generally attributed to depletion of activated naïve B cells and inhibition of B-cell activation. BEL's effect on MBCs is currently unexplained. We performed an in-depth cellular and transcriptomic analysis of BEL's impact on the blood MBC compartment in patients with SLE.
2344. Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus.
作者: Svenja Henning.;Tobias Reimers.;Wayel Abdulahad.;Juan J Fierro.;Berber Doornbos-van der Meer.;Hendrika Bootsma.;Barbara Horvath.;Karina de Leeuw.;Johanna Westra.
来源: Rheumatology (Oxford). 2025年64卷3期1234-1242页
To investigate the proportion of low-density granulocytes (LDGs), circulating plasma neutrophil extracellular traps (NETs) and serum-induced NET formation in patients with incomplete SLE (iSLE) and SLE.
2345. Serum proteomic profiles of patients with chronic recurrent multifocal osteomyelitis.
作者: Jun-Ichi Kawada.;Makoto Yamaguchi.;Kazunori Haruta.;Yuto Fukuda.;Ken-Ichi Iwata.;Takako Suzuki.;Yuka Torii.
来源: Rheumatology (Oxford). 2025年64卷3期1138-1146页
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disease characterized by sterile bone inflammation; however, its pathophysiology is poorly understood. Thus, this study aimed to characterize the serum proteomic profiles of patients with CRMO to better understand the molecular mechanisms underpinning CRMO pathogenesis.
2346. Description of the characteristics of the nailfold capillary structure in healthy children: a multi-centric study.
作者: Hatice Adıgüzel Dundar.;Amra Adrovic.;Selcan Demir.;Ferhat Demir.;Figen Cakmak.;Nuray Aktay Ayaz.;Betul Sözeri.;Yelda Bilginer.;Ozgur Kasapçopur.;Erbil Unsal.
来源: Rheumatology (Oxford). 2024年63卷SI2期SI152-SI159页
Nailfold videocapillaroscopy (NVC) is the primary diagnostic tool for the assessment of microcirculation in the pediatric population.
2347. Design of ANCHOR-RA: a multi-national cross-sectional study on screening for interstitial lung disease in patients with rheumatoid arthritis.
作者: Jeffrey A Sparks.;Philippe Dieudé.;Anna-Maria Hoffmann-Vold.;Gerd R Burmester.;Simon Lf Walsh.;Michael Kreuter.;Christian Stock.;Steven Sambevski.;Margarida Alves.;Paul Emery.
来源: BMC Rheumatol. 2024年8卷1期19页
Patients with rheumatoid arthritis (RA) are at risk of developing interstitial lung disease (ILD), which is associated with high mortality. Screening tools based on risk factors are needed to decide which patients with RA should be screened for ILD using high-resolution computed tomography (HRCT). The ANCHOR-RA study is a multi-national cross-sectional study that will develop a multivariable model for prediction of RA-ILD, which can be used to inform screening for RA-ILD in clinical practice.
2348. Efficacy and safety of guselkumab in patients with active psoriatic arthritis who had inadequate efficacy and/or intolerance to one prior tumor necrosis factor inhibitor: study protocol for SOLSTICE, a phase 3B, multicenter, randomized, double-blind, placebo-controlled study.
作者: Alexis Ogdie.;Joseph F Merola.;Philip J Mease.;Christopher T Ritchlin.;Jose U Scher.;Kimberly Parnell Lafferty.;Daphne Chan.;Soumya D Chakravarty.;Wayne Langholff.;Yanli Wang.;Olivia Choi.;Yevgeniy Krol.;Alice B Gottlieb.
来源: BMC Rheumatol. 2024年8卷1期20页
Tumor necrosis factor inhibitors (TNFi) are frequently chosen as the first biologic for patients with psoriatic arthritis (PsA). Given that many patients with PsA are TNFi inadequate responders (TNF-IR; either inadequate efficacy or intolerance), treatments utilizing alternative mechanisms of action are needed. In phase 3 studies, the fully human interleukin (IL)-23p19 subunit-inhibitor, guselkumab, was efficacious in patients with active PsA, including TNFi-IR. Efficacy was generally consistent between TNFi-naïve and TNFi-experienced cohorts; however, in the latter, higher response rates have been observed with the Q4W dosing regimen relative to the Q8W dosing regimen for some endpoints, suggesting the need to evaluate whether more frequent dosing may provide an incremental clinical benefit for TNFi-IR patients.
2351. The influence of the cardiac cycle on the halo sign and its impact on the ultrasound diagnosis of giant cell arteritis.
作者: Elisa Fernández-Fernández.;Emma Brugarolas.;Irene Monjo-Henry.;Marta Novella-Navarro.;Alejandro Balsa.;Eugenio De Miguel.
来源: Rheumatology (Oxford). 2025年64卷3期1459-1463页
To investigate whether hypoechoic wall thickness is influenced by the systole or diastole moment in the cardiac cycle and if this can influence US assessments of GCA.
2353. Identification and characteristics of patients with potential difficult-to-treat psoriatic arthritis: exploratory analyses of the Greek PsA registry.
作者: Konstantinos D Vassilakis.;Charalampos Papagoras.;Nikolaos Fytanidis.;Sousana Gazi.;Evangelia Mole.;Michael Krikelis.;Paraskevi V Voulgari.;Evripidis Kaltsonoudis.;Nikolaos Koletsos.;Dimitrios Boumpas.;Pelagia Katsimpri.;Dimitrios Katsifis-Nezis.;Theodoros Dimitroulas.;Nikolaos Kougkas.;Maria Boutel.;Petros P Sfikakis.;Maria G Tektonidou.;Chrysoula Gialouri.;Dimitrios Bogdanos.;Theodora Simopoulou.;Christos Koutsianas.;Evgenia Mavrea.;Gkikas Katsifis.;Konstantinos Kottas.;Maria Konsta.;Matthoula Tziafalia.;Evangelia Kataxaki.;Eleni Kalavri.;Kalliopi Klavdianou.;Eleftheria P Grika.;Charalampos Sfontouris.;Dimitrios Daoussis.;George Iliopoulos.;Ilias Bournazos.;Dimitrios Karokis.;Konstantinos Georganas.;Dimos Patrikos.;Dimitrios Vassilopoulos.;George E Fragoulis.
来源: Rheumatology (Oxford). 2024年63卷9期2427-2432页
To present the characteristics of patients with potential difficult-to-treat (D2T) PsA.
2354. Transorbital ultrasound in the diagnosis of giant cell arteritis.
作者: Simon M Petzinna.;Lara C Burg.;Claus-Juergen Bauer.;Pantelis Karakostas.;Jan H Terheyden.;Charlotte Behning.;Frank G Holz.;Peter Brossart.;Robert P Finger.;Valentin S Schäfer.
来源: Rheumatology (Oxford). 2024年63卷9期2379-2386页
The objective of this study was to prospectively evaluate the diagnostic efficacy of transorbital ultrasound (TOS) in patients newly diagnosed with giant cell arteritis (GCA), presenting with visual symptoms.
2355. Native myocardial T1 and right ventricular size by CMR predict outcome in systemic sclerosis-associated pulmonary hypertension.
作者: Daniel S Knight.;Ruta Virsinskaite.;Nina Karia.;Alice R Cole.;Rory H Maclean.;James T Brown.;Rishi K Patel.;Yousuf Razvi.;Lucia Venneri.;Tushar Kotecha.;Ana Martinez-Naharro.;Peter Kellman.;Ann M Scott-Russell.;Benjamin E Schreiber.;Voon H Ong.;Christopher P Denton.;Marianna Fontana.;J Gerry Coghlan.;Vivek Muthurangu.
来源: Rheumatology (Oxford). 2024年63卷10期2678-2683页
Measures of right heart size and function are prognostic in systemic sclerosis-associated pulmonary hypertension (SSc-PH), but the importance of myocardial tissue characterisation remains unclear. We aimed to investigate the predictive potential and interaction of cardiovascular magnetic resonance (CMR) myocardial tissue characterisation and right heart size and function in SSc-PH.
2356. Distinct features of ANCA-associated hypertrophic pachymeningitis compared with other etiologies: findings from a study of 74 patients.
作者: Eduardo Martín-Nares.;Griselda Romero-Sánchez.;Edwin Ulises Cortez-Domínguez.;Lilian Guadalupe Cano-Cruz.;Andrea Hinojosa-Azaola.
来源: Rheumatology (Oxford). 2025年64卷3期1292-1301页
We aimed to characterize the clinical and radiological features, and outcomes, of a large cohort of hypertrophic pachymeningitis (HP) patients from a single centre.
2357. Comparison of symptoms between diagnosis and relapse in giant cell arteritis: a retrospective cohort study.
作者: Lien Moreel.;Albrecht Betrains.;Ellen De Langhe.;Steven Vanderschueren.;Daniel Blockmans.
来源: Rheumatology (Oxford). 2024年63卷12期e325-e327页 2358. Clinical and economic burden of organ damage among patients with systemic lupus erythematosus in a real-world setting in Germany.
作者: Michael Schultze.;Elena Garal-Pantaler.;Marc Pignot.;Roger A Levy.;Heike Carnarius.;Matthias Schneider.;Kerry Gairy.
来源: BMC Rheumatol. 2024年8卷1期18页
Systemic lupus erythematosus (SLE), a chronic multisystem autoimmune disease, carries high risk of organ damage and burden to healthcare systems. SLE disease modification aims to reduce disease activity with minimal treatment toxicity and preventing or minimizing organ damage development. This real-world study utilizing healthcare administrative claims data assessed organ damage development, associated costs and healthcare resource utilization (HCRU) in patients with SLE in Germany.
2360. Effect of bimekizumab on patient-reported disease impact in patients with psoriatic arthritis: 1-year results from two phase 3 studies.
作者: Laure Gossec.;Ana-Maria Orbai.;Maarten de Wit.;Laura C Coates.;Alexis Ogdie.;Barbara Ink.;Jason Coarse.;Jérémy Lambert.;Vanessa Taieb.;Dafna D Gladman.
来源: Rheumatology (Oxford). 2024年63卷9期2399-2410页
To evaluate 1-year bimekizumab efficacy in PsA from the patient perspective using the 12-item PsA Impact of Disease (PsAID-12) questionnaire.
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