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2302. Comparison of rituximab efficacy in treatment-naïve and refractory inflammatory myopathies: experiences from a tertiary care centre.
作者: Abhilasha Manwatkar.;Kancha Naresh.;John Mathew.;Aditya V Nair.;Ruchika Goel.;Bijesh Yadav.;John Antony Jude Prakash.;John Kumar Das.;Ajith Sivadasan.
来源: Rheumatology (Oxford). 2025年64卷4期2091-2098页
To determine whether rituximab (RTX) is effective in 'treatment-naïve' idiopathic inflammatory myopathies (IIM), and whether there could be differential treatment responses between 'treatment-naïve' and treatment 'refractory' IIM.
2303. Exploring relief for Behçet's disease refractory oral ulcers: a comparison of TNF inhibitors versus apremilast.
作者: Giuseppe Lopalco.;Maria Morrone.;Vincenzo Venerito.;Luca Cantarini.;Giacomo Emmi.;Gerard Espinosa.;Gema Maria Lledó.;Marta Mosca.;Rosaria Talarico.;Alberto Cauli.;Matteo Piga.;Jurgen Sota.;Claudia Fabiani.;Emanuele Chiara.;Edoardo Biancalana.;Irene Mattioli.;Lorenza Maria Argolini.;Federica Di Cianni.;Roberto Caporali.;Florenzo Iannone.
来源: Rheumatology (Oxford). 2025年64卷3期1302-1308页
Oral and genital ulcers are the hallmark manifestation of Behçet's disease (BD), significantly impacting patients' quality of life. Our study focuses on comparing the effectiveness and safety of TNF inhibitors (TNFis) and apremilast in controlling oral ulcers of BD, aiming to provide evidence-based guidance for physicians in selecting appropriate treatment modalities.
2304. Familial Mediterranean fever in patients with inflammatory bowel diseases: a nationwide study from the epi-IIRN.
作者: Michal Kori.;Rachel Buchuk.;Ofra Goldzweig.;Yiska Loewenberg Weisband.;Noa Tal.;Amir Ben-Tov.;Natan Ledderman.;Eran Matz.;Moti Freiman.;Iris Dotan.;Dan Turner.;Dror S Shouval.
来源: Rheumatology (Oxford). 2025年64卷3期1347-1354页
Inflammatory bowel diseases (IBD) and familial Mediterranean fever (FMF) are auto-inflammatory diseases with common clinical and biological features. We aimed to determine their association and characterize the natural history in patients with both diagnoses.
2305. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
This study aimed to investigate the effect of vitamin D supplementation therapy on disease activity and fatigue in rheumatoid arthritis (RA) patients.
2307. Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria.
作者: Gbenga Joshua Odunlami.;Adeola Ajibade.;Bolanle Aderonke Omotoso.;Muzamil Olamide Hassan.;Adeyemi Abiola Adefidipe.;Fatai Olatunde Olanrewaju.;Ademola Olusegun Enitan.;Tajudin Adesegun Adetunji.;Olumide Akinniyi Akinyele.;Oluyomi Okunola.
来源: Reumatologia. 2024年62卷2期83-93页
The aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population.
2308. Level of glial cell derived neurotrophic factor in the blood plasma of rheumatoid arthritis patients and its relationship with alexithymia.
Glial cell derived neurotrophic factor (GDNF) has an important role in the pathogenetic mechanisms and clinical manifestations of rheumatoid arthritis (RA). Alexithymia is associated with a severe clinical course and worse prognosis, while the relationship between alexithymia and GDNF in RA patients has not been investigated before. The aims of the study were to investigate the GDNF level in blood plasma in RA patients depending on the presence of alexithymia and to evaluate the relationship of GDNF level with clinical manifestation and quality of life.
2309. Bilateral rapidly destructive coxopathy in rheumatoid arthritis.
作者: Stoimen Dimitrov.;Georgi Gerganov.;Simona Bogdanova.;Svetlana Hristova.;Rosina Moraliyska.;Svetoslav Dimitrov.;Zhaklin Apostolova.;Desislava Simeonova.;Tanya Shivacheva.;Tsvetoslav Georgiev.
来源: Reumatologia. 2024年62卷2期134-141页
Rapidly destructive coxopathy (RDC) is a rare type of coxarthritis marked by swift deterioration of the hip joint. Although its cause remains unclear, several pathophysiological mechanisms are proposed. To comprehensively analyze this poorly understood condition, a literature search was conducted focusing on associations of bilateral RDC and rheumatoid arthritis (RA). The problem of long-standing RA, bilateral RDC with a febrile episode that preceded a rapid decline in mobility and severe hip pain, with radiological assessment confirmed bilateral hip destruction, was presented. Rapidly destructive coxopathy, especially when linked to RA, poses diagnostic and therapeutic challenges. Our review confirmed by the clinical picture emphasizes the need for vigilance in RA patients with hip involvement and calls for further research to understand RDC's mechanisms and enhance clinical care.
2310. Patterns and prevalence of psychiatric morbidity among individuals with rheumatoid arthritis.
作者: Ajaz Kariem Khan.;Junaid Nabi.;Ashaq Hussain Parrey.;Prasan Deep Rath.;Sanan Lone.
来源: Reumatologia. 2024年62卷2期115-120页
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints, causing inflammation, pain, and potential joint damage. Patients with RA are at high risk of developing psychiatric morbidity; it is important to recognize these psychiatric manifestations. The relationship between psychiatric symptoms and RA is complex and can involve various factors, including the impact of chronic pain, inflammation, medications, and the overall burden of managing a chronic illness.Aim of the study was to systematically investigate and analyze the patterns and prevalence of psychiatric morbidity among individuals diagnosed with RA, with the aim of identifying common mental health conditions, understanding the interplay between RA and psychiatric disorders, and providing valuable insights for improved holistic patient care.
2311. Assessment of hematologic indices for diagnosis in juvenile systemic lupus erythematosus.
The aim was to present effective approaches utilizing novel hematological parameters for early diagnosis of juvenile-onset systemic lupus erythematosus (jSLE).
2312. Indications, response, and side effects of biologic treatment in Behçet's disease: an 8-year study with follow-up.
作者: Saeedeh Shenavandeh.;Elham Aflaki.;Maryam Rasti Jahromi.;Afshin Borhani Haghighi.;Mohammad Ali Nazarinia.
来源: Reumatologia. 2024年62卷2期101-108页
The treatment of Behçet's disease has improved significantly with the introduction of biologic therapies. However, there is still a need for more information about their use. This study aimed to evaluate the indications, response, and side effects of biologic agents in patients with refractory or severe Behçet's disease in the south of Iran, their follow-up and reasons for changing the biologics.
2313. Bone turnover markers and muscle decay indicator in patients with proximal femur fracture - a case-control study.
作者: Marcin Łapiński.;Krystian Żarnovsky.;Katarzyna Czarzasta.;Bartosz Maciąg.;Grzegorz Maciąg.;Olga Adamska.;Artur Mamcarz.;Artur Stolarczyk.
来源: Reumatologia. 2024年62卷2期121-127页
Fracture of the proximal femur is common in elderly patients, in fact threatening their lives. Age-related sarcopenia may be involved in the imbalance resulting in the injury. Handy and readily accessible biochemical tests would be useful to assess the musculoskeletal system condition in daily practice. The aim of the study was to determine whether there is any relation between muscle decay and fracture of the proximal femur and to assess bone quality in elderly patients.
2314. Impact of acetabular roof's angle on precision of cup center of rotation reproduction and placement in total hip arthroplasty.
作者: Bartosz Maciąg.;Dawid Jegierski.;Bartłomiej Wilk.;Martyna Budzińska.;Grzegorz Maciąg.;Anna Kupczak.;Krystian Żarnovsky.;Marcin Łapiński.;Tomasz Kordyaczny.;Artur Stolarczyk.
来源: Reumatologia. 2024年62卷2期128-133页
Total hip arthroplasty (THA) is nowadays considered as the most effective treatment option for end-stage hip osteoarthritis (OA) and one of the most successful orthopedic procedures. Precise reproduction of the center of rotation (COR) is among the most important aspects of recreating native hip biomechanics after THA as it is strictly related to muscle tension and force distribution within the hip joint. Both vertical and horizontal shift in cup positioning and COR restoration are commonly observed radiological signs corresponding with lesser functional outcome. The aim of this study was to assess whether the superior border of the native acetabulum morphology has an impact on cup positioning and COR restoration in patients undergoing THA as treatment of primary OA of the hip.
2315. Ramosetron as an add-on therapy for refractory fibromyalgia: a randomized, double-blind, placebo-controlled trial.
作者: Dong-Jin Park.;Hyemin Jeong.;Sung-Eun Choi.;Ji-Hyoun Kang.;Jung-Kil Lee.;Shin-Seok Lee.
来源: Rheumatology (Oxford). 2024年63卷9期2372-2378页
This study aimed to assess the efficacy and safety of intravenous ramosetron for pain relief in patients with fibromyalgia (FM) unresponsive to conventional treatments.
2316. Anti-HMGCR myopathy: estimated five-fold higher incidence in Polynesian compared with European populations in Aotearoa/New Zealand.
作者: Ke Li Chow.;Paula Elizabeth Keating.;John Liston O'Donnell.
来源: Rheumatology (Oxford). 2025年64卷3期1362-1368页
In 2014 the incidence of anti-3-hydroxy-3-methylglutaryl-CoA-reductase (HMGCR) myopathy in New Zealand was ∼1.7 case/million persons/year. This study aimed to re-estimate the population incidence and assess ethnic variation in those aged >40 years old.
2317. Ex vivo cell-based assay for assessment of response to TNF inhibitors in patients with rheumatic diseases.
作者: Smadar Gertel.;May Rokach.;Ari Polachek.;David Levartovsky.;Adi Broyde.;Victoria Furer.;Tali Ofir Dovrat.;Jonathan Wollman.;Sara Pel.;Yoram Neufeld.;Ori Elkayam.
来源: Rheumatology (Oxford). 2025年64卷4期2233-2241页
There are five TNF inhibitors (TNFis), whose structure and signalling differ. An individual patient with a rheumatic disease may respond to one TNFi but not to another. In addition, 30-40% of patients with rheumatic diseases may respond inadequately to TNFis. The downstream signalling of the various TNFis may determine their clinical efficacy. Several reports have shown that the different TNFis exhibited differential effects on Th17 cells. We analysed the effects of the various TNFis on IL-17A expression in peripheral blood mononuclear cells (PBMCs) of patients with rheumatic diseases, in order to evaluate the possibility of predicting responses in an ex vivo setting.
2318. Extracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies-a potential lifesaving intervention.
作者: Boyang Zheng.;Ellen Eline.;Lillian Xu.;Kun Huang.;Greet Hermans.;Michael Perch.;Gordan Samoukovic.;Ellen De Langhe.;Maryam Dastmalchi.;Lisa Christopher-Stine.;Louise Pyndt Diederichsen.;Valérie Leclair.
来源: Rheumatology (Oxford). 2025年64卷4期2204-2208页
Idiopathic inflammatory myopathies (IIM) can present with acute IIM-related lung injury and respiratory failure, leading to a high mortality risk in intensive care units (ICU). Extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome can be lifesaving. We aimed to report a case series of IIM patients that received ECMO.
2320. Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization.
作者: Sizheng Steven Zhao.;Sarah L Mackie.;Susanna C Larsson.;Stephen Burgess.;Shuai Yuan.
来源: Rheumatology (Oxford). 2025年64卷5期3012-3018页
PMR is an age-related inflammatory disease of unknown cause. We aimed to identify potentially modifiable risk factors and therapeutic targets for preventing or treating PMR.
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