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181. Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via Nrf2/GPX4 signaling.
Irisin, a recently identified protein that is released during exercise and promotes the transformation of white adipocytes into brown adipocytes. The expression of irisin in the liver suggests its possible involvement in liver function and performance, however it has not been comprehensively investigated.
182. Diagnosis model for gastric submucosal tumor based on multiple decision trees comprising endoscopic and endoscopic ultrasonography features.
作者: Shen Su.;Shun-Yao Wu.;Yun-He Tang.;Lin-Lin Ren.;Fan Yin.;Yu-Shuang Xu.;Xiao-Yu Li.;Hua Liu.;Shao-Hua Zhang.;Xing-Lin Zhang.;Zi-Bin Tian.;Tao Mao.
来源: BMC Gastroenterol. 2025年25卷1期515页
The clinical course and manifestations of subepithelial lesions (SEL) patients tend to vary from different pathological types, therefore the accurate diagnosis of SEL would undoubtedly be beneficial to the treatment and prognosis of SEL patients. Based on the decision tree method, we developed a novel classification model for SELs by combining endoscopy with endoscopic ultrasound (EUS).
185. The prognostic value of immunoscore in the early-onset colorectal cancer.
The purpose of this study was to explore the prognostic value of Immunoscore in patients with early-onset colorectal cancer.
186. Prognostic value of the international normalized ratio to albumin ratio in acute pancreatitis: insights from MIMIC-IV database.
作者: XingYi Yang.;Yi Ying.;Min Zhang.;LiHong Lv.;XiaoXiao Wang.;JunWei Fang.
来源: BMC Gastroenterol. 2025年25卷1期511页
While the prognostic value of the international normalized ratio - to - albumin ratio (PTAR) has been established in several diseases, its predictive value in acute pancreatitis (AP) mortality remains uncertain. This study aimed to investigate the association between PTAR and survival outcomes in AP patients.
187. MRI findings of confluent hepatic fibrosis caused by different etiologies.
作者: Dan Yu.;Xiao-Hua Li.;Xue-Lin He.;Xi-Bin Jia.;Zhen-Chang Wang.;Zheng-Han Yang.;A-Hong Ren.
来源: BMC Gastroenterol. 2025年25卷1期512页
To identify the magnetic resonance imaging (MRI) features of confluent hepatic fibrosis (CHF) caused by different etiologies.
188. IgG4-related cholangitis - distinguishing from other benign biliary strictures: clinical features, imaging, and response to treatment: a retrospective study.
作者: Thanaput Kunlayawutipong.;Tanawat Pattarapuntakul.;Thanawin Wong.;Tanawat Jongraksak.;Nisa Netinatsunton.;Jaksin Sottisuporn.;Thanapon Yaowmaneerat.;Siriboon Attasaranya.;Pimsiri Sripongpun.
来源: BMC Gastroenterol. 2025年25卷1期514页
IgG4-related cholangitis (IRC) is a rare systemic fibroinflammatory disorder that can affect multiple secretory organs, posing diagnostic challenges. It mimics both benign biliary strictures (BBS) and malignant biliary strictures (MBS). A hallmark feature of IRC is its dramatic response to systemic corticosteroids. Misdiagnosis may lead to incorrect treatment or unwarranted surgical procedures. This study aimed to compare the baseline characteristics, laboratory test results, imaging findings, and treatment responses between IRC and other BBS groups.
189. Features of defecation dysfunction among patients with Hirschsprung disease in early childhood.
作者: Shiwen Pan.;Wei Li.;Chengpeng Shi.;Weibing Tang.;Changgui Lu.
来源: BMC Gastroenterol. 2025年25卷1期510页
Defecation dysfunction among patients with Hirschsprung disease (HD) in early childhood may persist into adulthood and lead to social problems. The features of defecation dysfunction in HD patients with different aganglionic segment lengths during early childhood have not been established. The present study was designed to identify and describe the features of defecation dysfunction among patients with HD in early childhood.
190. The impact of serum neuregulin 4 (NRG-4) levels on non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis.
作者: Mohammad Amin Tapak.;Smko Rashidian Glolan.;Yousef Moradi.
来源: BMC Gastroenterol. 2025年25卷1期509页
The aim of this systematic review and meta-analysis was to assess the association between serum neuregulin 4 (Nrg4) levels and non-alcoholic fatty liver disease (NAFLD).
191. Risk of Pancreatic Cancer in Glycemically Defined New-Onset Diabetes: A Prospective Cohort Study.
作者: Suresh T Chari.;Bechien Wu.;Camden Lopez.;Eva Lustigova.;Qiaoling Chen.;Stephen K Van Den Eeden.;Amethyst D Leimpeter.;William Fisher.;Amy Wood.;Ashley S Alexander.;John Valenta.;Santhi Swaroop Vege.;Erin E Carlson.;Kari G Rabe.;Phil A Hart.;Lu Qian.;Ying-Qi Zhao.;Nadia Yosuf.;Lynn Matrisian.;Barbara Kenner.;Jo Ann Rinaudo.;Anirban Maitra.;Ziding Feng.
来源: Gastroenterology. 2025年
The increased 3-year incidence of pancreatic cancer after new-onset diabetes observed in retrospective studies needs prospective validation. It is unknown whether incidence varies by race and ethnicity.
192. Chemical Perturbations Impacting Histone Acetylation Govern Colorectal Cancer Differentiation.
作者: Pornlada Likasitwatanakul.;Zhixin Li.;Paul Doan.;Sandor Spisak.;Akhouri Kishore Raghawan.;Qi Liu.;Priscilla Liow.;Sunwoo Lee.;David Chen.;Pratyusha Bala.;Pranshu Sahgal.;Daulet Aitymbayev.;Jennifer S Thalappillil.;Malvina Papanastasiou.;William Hawkins.;Steven A Carr.;Haeseong Park.;James M Cleary.;Jun Qi.;Nilay S Sethi.
来源: Gastroenterology. 2025年
Aberrant epigenetic programs that suppress differentiation and enhance plasticity drive colorectal cancer (CRC), yet the molecular determinants underlying these processes remain elusive. We aimed to identify and characterize epigenetic regulators of CRC differentiation, uncovering mechanisms that reprogram cancer cell states.
193. Metabolic dysfunction, cirrhosis, and HCV genotype 3a drive type 2 diabetes risk in chronic hepatitis C: a Southern Chinese cohort study.
Chronic hepatitis C (CHC) is associated with an increased risk of type 2 diabetes mellitus (T2DM). However, regional variations in HCV genotypes and clinical characteristics may influence this association. This study aimed to investigate the association between chronic hepatitis C virus (CHC) infection and the development of T2DM in CHC patients in Southern China.
194. Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series.
作者: Junzhen Hou.;Fandong Meng.;Bing Yue.;Peng Li.;Ningning Dong.
来源: BMC Gastroenterol. 2025年25卷1期507页
To investigate the clinicopathological characteristics of patients with pyloric gland adenoma (PGA), as well as their prognosis.
195. Efficacy and safety of ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma at specific anatomic sites of the liver: a systematic review and meta-analysis.
This meta-analysis aims to evaluate the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for hepatocellular carcinoma (HCC) located at specific anatomical sites of the liver compared with non-specific sites.
196. Intestinal microbiota in adults with cholangiocarcinoma identifies the dysregulated Blautia species and bile acid metabolic pathways.
作者: Tianyu De.;Tian Ma.;Wei Wang.;Xusheng An.;Di Liu.;Hongkun Yin.;Qi Wang.;Ting Zhao.;Hao Wang.
来源: BMC Gastroenterol. 2025年25卷1期506页
Cholangiocarcinoma (CCA) represents a significant global health concern. The gut and bile microbiota, which can influence the gut-liver axis and disease progression, have not been thoroughly characterized in CCA patients.
197. Long-term quality of life after acute pancreatitis: a systematic review and meta-analysis.
The long-term impact of acute pancreatitis (AP) on quality of life (QoL) remains inconclusive. This systematic review and meta-analysis aimed to evaluate long-term QoL outcomes in patients after AP.
198. Explainable machine learning model for predicting the transarterial chemoembolization response and subtypes of hepatocellular carcinoma patients.
作者: Yunjie Zhang.;Songjian Tong.;Junhui Yang.;Jiawei Lin.;Yifan Kong.;Deyu Lu.;Yan Chen.;Yingchao Li.;Linfeng Xu.;Xiuyan Kong.;Guoqing Zhu.;Hao Zhang.;Pixu Liu.;Zhijie Yu.;Jinglin Xia.
来源: BMC Gastroenterol. 2025年25卷1期503页
Hepatocellular carcinoma (HCC), the third leading cause of cancer-related deaths globally, faces heterogeneous responses to transarterial chemoembolization (TACE) in intermediate-stage disease. We developed a Machine Learning (ML)-based model integrating routine clinical variables to preoperatively predict TACE efficacy, enabling tailored TACE candidate selection and optimized therapeutic decision-making.
199. Sexual function, depression, and quality of life in patients with irritable bowel syndrome.
作者: Amir Keshavarzi.;Seyed Saman Talebi.;Mohammad Ahmadpanah.;Alireza Soltanian.;Saman Torkashvand.
来源: BMC Gastroenterol. 2025年25卷1期504页
Irritable bowel syndrome (IBS) is a prevalent functional disorder of the gastrointestinal (GI) tract, often accompanied by depression and sexual dysfunction. Depression and IBS may share similar pathophysiological mechanisms, making it essential to understand them for effective treatment. This study aims to compare the state of sexual function, depression, and quality of life in IBS patients experiencing depression with that of healthy subjects.
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