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2. Circulating extracellular vesicle long RNA profiling combined with machine learning unveils novel diagnostic signature and molecular features in chronic pancreatitis.
作者: Yu Cao.;Jia Hu.;Jun Ye.;Duowu Zou.;Zheng Wang.;Tao Yin.;Wanxing Duan.;Xuesong Liang.;Jinying Chen.;Yuchen Li.;Hongyan Lai.;Shulin Yu.;Zhen Wang.;Yahui Wang.;Peng Wang.;Zhaoshen Li.;Wenbin Zou.;Shenglin Huang.;Zhuan Liao.
来源: Gut. 2026年
No clinically useful non-invasive biomarkers have been developed for diagnosis of chronic pancreatitis (CP), and molecular features of CP have not been characterised. Extracellular vesicles (EVs) consisted of abundant RNA species with specialised functions and clinical applications.
3. Targeting PKM2-dependent glycolysis reprogrammes monocytes into Cadm1+ macrophages to promote mucosal repair and attenuate colitis progression.
作者: Di Zhang.;Ping Tao.;Jinying Li.;Xingyan Zhou.;Hengdong Qu.;Yaobin Li.;Haoxian Chen.;Hui Yuan.;Jiabin Huang.;Ziyi Ji.;Pengqing Sun.;Haoting Lin.;Keke Zhang.;Wei Huang.;Huixin Chen.;Wencai Ye.;Jian Hong.
来源: Gut. 2026年
Incomplete mucosal healing contributes to progression and relapse in ulcerative colitis (UC). Currently, therapeutic strategies that promote mucosal healing and regeneration are limited and may potentiate oncogenic transformation.
4. CD16+ γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection.
作者: Paulina E Schröter.;Katja Steppich.;Laura Fernández Carrera.;Zheng Song.;Sebastian Klein.;Roni Souleiman.;Melanie Urbanek-Quaing.;Ayesha D Lietzau.;Ansgar Schnieders.;Erich Freyer.;Birgit Bremer.;Ximena León-Lara.;Vicente Almeida.;Rodrigo Gutierrez Jauregui.;Constantin Von Kaisenberg.;Matthias Bruhn.;Carla Meineke.;Ulrich Kalinke.;Heiner Wedemeyer.;Immo Prinz.;Sarina Ravens.;Arnaud Carpentier.;Yannic Christoph Bartsch.;Anke R M Kraft.;Markus Cornberg.
来源: Gut. 2026年
Chronic hepatitis B virus (HBV) infection is characterised by immune dysfunction. While conventional T cell responses have been extensively studied, the role of γδ T cells, innate-like cytotoxic lymphocytes enriched in the liver, remains incompletely understood.
7. Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury.
作者: Ruhong Tu.;Hua-Long Zheng.;Biyun Zheng.;Qing Zhong.;Jin Qian.;Qian Yu.;Feijing Wu.;Toshiro Shiokawa.;Yosuke Ochiai.;Hiroki Kobayashi.;Quin T Waterbury.;Leah Zamechek.;Youxin Gao.;Satoru Takahashi.;Seiya Mizuno.;Chang Ming Huang.;Ping Li.;Yoku Hayakawa.;Timothy C Wang.
来源: Gut. 2026年
Spasmolytic polypeptide-expressing metaplasia (SPEM) arises in the gastric corpus in response to oxyntic atrophy, but its cellular origin and role in gastric cancer remain unclear.
8. Proton pump inhibitors should be continued after endoscopic variceal ligation.
作者: Abhishek Yadav.;Harshal Surendra Mandavdhare.;Vishal Sharma.;Atul Saroch.;Jimil Shah.;Nitin Jagtap.;Anupam Kumar Singh.;Jayanta Samanta.;Vaneet Jearth.;Usha Dutta.;Saroj Kant Sinha.
来源: Gut. 2026年 9. Stromal biomarker-based framework for identifying pMMR/MSS and dMMR/MSI colorectal cancers with poor outcomes and limited benefit from immunotherapy.
作者: Mar Iglesias Coma.;Jordi Badia-Ramentol.;Carolina Martinez-Ciarpaglini.;Jenniffer Linares.;Noelia Tarazona.;Nuria Mulet-Margalef.;Paula Tornero-Piñero.;Anna Sallent-Aragay.;Alba Recort-Bascuas.;Joan Gibert.;Marta Sant-Albors.;Daniele V F Tauriello.;Melba Cruz-Moral.;Marina Carreras-Gallardo.;Elena Sancho.;Clara Morral Martinez.;Marta Garrido.;Jose Luis Manzano Mozo.;Andrés Cervantes.;Clara Montagut.;Eduard Batlle.;Alexandre Calon.
来源: Gut. 2026年
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, with clinical progress limited by intratumoural cellular diversity and the absence of robust, informative markers.
11. Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease.
作者: Sara Reinartz Groba.;Mathis Richter.;Dennis Schwarz.;Philipp Seyfried.;Kristian Serafimov.;Xiaoqing Fu.;Luca Farinola.;Jan-Niklas Heming.;Max Masthoff.;Michael Köhler.;Alexander Zarbock.;Yahya Sohrabi.;Michael Praktiknjo.;Angelika S Rambold.;Raphael Chevre.;Michael Lämmerhofer.;Jonel Trebicka.;Oliver Soehnlein.
来源: Gut. 2026年
Neutrophils guarantee a prompt and robust host response to pathogens. Yet, overshooting neutrophil activation leads to tremendous collateral damage in tissues. In advanced chronic liver disease (ACLD), neutrophils are exposed to the highly immunogenic milieu of the portal circulation prior to entering the liver sinusoids. In alcohol-related liver disease (ALD), neutrophils occupy a central role and therefore mechanisms regulating neutrophil activity pose a possible therapeutic target.
12. Bifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8+ T cells.
作者: Xiang Li.;Mingxu Xie.;Jason Xing Kang.;Yue Chen.;Jing Han.;Yinnan Chen.;Qian Chen.;Tianyu Yu.;Shuyan Liu.;Zhenlin Ouyang.;Qiong Sun.;Kai Li.;Shaoqiang Zhang.;Junjun She.;Jun Yu.
来源: Gut. 2026年
Certain gut bacteria are associated with improved responses to immunotherapy.
13. Quantifying artificial sweeteners and emulsifiers in Crohn's disease and its relationship with disease activity: the ENIGMA study - a novel and targeted approach.
作者: Jingwan Zhang.;Jielun Hu.;Xinyi Tang.;Yanjiao Ruan.;Fangjia Hao.;Wenqing Zhang.;Gina Trakman.;Amy L Hamilton.;Winnie Lin.;Yang Sun.;Jessica Y L Ching.;Jing Jie Teh.;Seungha Kang.;Amy Wilson-O' Brien.;Annalise Stanley.;Lin Zhang.;Joseph J Y Sung.;Jun Yu.;Yinglei Miao.;Francis K L Chan.;Mark Morrison.;Michael Kamm.;Siew C Ng.
来源: Gut. 2026年
Food additives have been linked to increased Crohn's disease (CD) risk and activity, but their human quantification has not been explored.
14. RNA binding protein CAPRIN1 suppresses STAT1 translation and interferon signalling to promote HBV replication.
作者: Jing Peng.;Zheng Ding.;Qu Liu.;Liwei Zhang.;Juan Chen.;Guixi Chen.;Yuebin Gao.;Siyu Wang.;Xiaomin Tian.;Yuqiu Wei.;Ourania Andrisani.;Yixuan Li.;Fazheng Ren.;Jiazeng Sun.
来源: Gut. 2026年
A G-quadruplex (rG4) structure within 5' untranslated region (5'UTR) of Signal Transducer and Activator of Transcription 1 (STAT1) messenger RNA (mRNA) functions as a translational brake modulating STAT1 translation and regulating interferon (IFN) response. We hypothesised that rG4-interacting proteins could be pivotal modulators of STAT1 expression and, consequently, IFN therapy for HBV resistance.
15. Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment.
作者: Jiazheng Jiao.;Lele Song.;Shengjun Xu.;Yuan Xue.;Yanyan Liao.;Keying Xu.;Qian Wen.;Kai Xiang.;Rongrong Chen.;Xiaoxia Dong.;Weiwei Ji.;Yinlong Guo.;Gang Li.;Haibiao Bao.;Xiao Xu.;Lixing Zhan.
来源: Gut. 2026年
The hepatocellular carcinoma (HCC) immune microenvironment is heavily influenced by immunosuppressive neutrophils, yet the mechanisms driving their senescence-associated reprogramming remain elusive.
16. Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case-control study.
作者: Annelies Boven.;Harry Vranken.;Erika Vlieghe.;Annemarie Boleij.;Katja Fall.;Lars Engstrand.;Nele Brusselaers.
来源: Gut. 2026年
Clostridioides difficile infections (CDIs) are associated with antibiotic use, although the link with other drugs remains underexplored.
17. Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes.
作者: Yuping Chen.;Bingtian Dong.;Xinrui Jin.;Chuan Liu.;Ming-Hua Zheng.;Xiao Liang.;Yameng Sun.;Hye Won Lee.;Huapeng Lin.;Emmanuel Tsochatzis.;Salvatore Petta.;Elisabetta Bugianesi.;Masato Yoneda.;Hannes Hagström.;Jérôme Boursier.;José Luis Calleja.;George Boon-Bee Goh.;Wah-Kheong Chan.;Rocio Gallego-Durán.;Arun J Sanyal.;Victor de Lédinghen.;Philip N Newsome.;Jian-Gao Fan.;Laurent Castéra.;Michelle Lai.;Céline Fournier-Poizat.;Grace Lai-Hung Wong.;Grazia Pennisi.;Angelo Armandi.;Atsushi Nakajima.;Wen-Yue Liu.;Ying Shang.;Marc de Saint-Loup.;Elba Llop.;Kevin Kim Jun Teh.;Carmen Lara-Romero.;Amon Asgharpour.;Sara Mahgoub.;Mandy Sau-Wai Chan.;Adrien Lannes.;Manuel Romero-Gomez.;Airong Hu.;Yiling Li.;Qing-Lei Zeng.;Wei Gou.;Hua Bian.;Xiao Han.;Chenlin Sun.;Seung Up Kim.;Terry Cheuk-Fung Yip.;Gao-Jun Teng.;Vincent Wai-Sun Wong.;Xiaolong Qi.; .
来源: Gut. 2026年75卷3期576-587页
Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).
19. Diagnostic endoscopic resection for assessing potential residual disease after neoadjuvant therapy for oesophageal adenocarcinoma.
作者: Aleksandra Sztogrin-Pluta.;Katarzyna Polomska.;Joanna Podgorska.;Andrzej Mroz.;Tomasz Olesinski.;Nastazja Dagny Pilonis.;Michal F Kaminski.
来源: Gut. 2026年 20. Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study.
作者: Jorge F Vázquez-Castellanos.;Sang Jun Yoon.;Sung-Min Won.;Jeroen Raes.;Hak Cheol Kwon.;Jiyeon Si.;Ki Tae Suk.
来源: Gut. 2026年
The gut-liver axis plays a critical role in liver disease progression; however, how gut microbial ecology and function vary across disease stages remains unclear.
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