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1. A serum TNFR2-based model effectively predicates preoperative microvascular invasion and stratifies the tumor recurrence risk in hepatocellular carcinoma.
作者: Peiru Zhang.;Jianyong Zhuo.;Huigang Li.;Modan Yang.;Jinyan Chen.;Xudong Yang.;Chenghao Cao.;Shusen Zheng.;Xiao Xu.;Di Lu.
来源: BMC Gastroenterol. 2025年25卷1期622页
Microvascular invasion (MVI) is a key risk factor for hepatocellular carcinoma (HCC) recurrence. There is a lack of methods to diagnose MVI preoperatively. The objective of this study was to develop a model for preoperative prediction of MVI in HCC.
2. A Multi-marker model based on serum IL-10 predicts response to conversion immunochemotherapy in gastric cancer patients: a retrospective cohort study.
作者: Xingzhou Wang.;Hang Jiang.;Mengjie Liang.;Daming Cai.;Shichao Ai.;Qiongyuan Hu.;Feng Wang.;Feng Sun.;Xuefeng Xia.;Peng Song.;Liang Tao.;Song Liu.;Meng Wang.;Xiaofeng Lu.;Wenxian Guan.;Xiaofei Shen.
来源: BMC Gastroenterol. 2025年25卷1期621页
Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low. Little evidence has shown how to easily predict therapeutic efficacy from hematological biomarkers, apart from tissue biomarkers. This study aimed to identify predictive factors for treatment response from hematological biomarkers and propose strategies for non-responsive patients.
3. Resveratrol mitigates aspirin-induced intestinal injury in rats in a high-altitude hypoxic environment associated with reducing the expression levels of angiotensin II.
作者: Paziliya Abulaiti.;Wen Hui Shi.;Huan Liu.;Ailifeire Tuerxuntayi.;Kailibinuer Nuermaimaiti.;Zhuo Shuyi Liu.;Yingying Xing.;Najimangu Rehemutula.;Kudelaiti Abdukelimu.;Weidong Liu.;Jiang Wei Liu.;Feng Gao.
来源: BMC Gastroenterol. 2025年25卷1期623页
This study aimed to investigate whether the polyphenolic compound resveratrol can protect against intestinal injury induced by aspirin in hypoxic rats associated with the inhibition of angiotensin II (Ang-II), as well as mitigating intestinal mucosal oxidative stress and inflammation.
4. Association between serum albumin to creatinine ratio and non-alcoholic fatty liver disease: a longitudinal cohort study in non-obese Chinese individuals.
作者: Weitao Wu.;Donghai Wu.;Fanglan Chen.;Shihua Ding.;Ying Ying.;Dayong Sun.;Haofei Hu.
来源: BMC Gastroenterol. 2025年25卷1期620页
There is limited research on the association between serum albumin to creatinine ratio (sACR) and non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the association between sACR and NAFLD risk in non-obese Chinese individuals.
6. Prognostic comparison between LNM and MaVI of hepatocellular carcinoma: a multicenter population-based propensity scores matching study.
作者: Jinyu Zhang.;Yifan Chen.;Peng Ye.;Qionglan Wu.;Jingfeng Liu.;Jianxing Zeng.
来源: BMC Gastroenterol. 2025年25卷1期618页
Hepatocellular carcinoma (HCC) with lymph node metastases (LNM) is an uncommon neoplasm and has an ambivalent prognosis compared to the common type of HCC with macrovascular invasion (MaVI).
7. Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study.
作者: Xing Gao.;Hao Gao.;Song Wang.;Futian Tang.;Yang Zhao.;Yumin Li.
来源: BMC Gastroenterol. 2025年25卷1期619页
Over the past few decades, the global incidence of cholangiocarcinoma has risen overall. In particular, the incidence of intrahepatic cholangiocarcinoma increased by 109% over a ten-year period, rising from 0.67 per 100,000 in 2007 to 1.40 per 100,000 in 20161. Epidemiological studies have suggested that cholecystitis may increase the risk of hepatobiliary cancers. However, whether this association indicates an independent causal relationship remains unclear. Given that observational studies are prone to residual confounding and bias, limiting the strength of causal inference. Our study aimed to evaluate whether cholecystitis is an independent risk factor for cholangiocarcinoma.
8. MAFLD outperforms NAFLD in identifying metabolic dysfunction in U.S. adolescents: a NHANES 2017-2020 analysis.
作者: Yigui Zou.;Yu Dai.;Hu Chen.;Ziyuan Li.;Baixian Lin.;Zeling Zhuang.;Wenwen Li.;Qinghua Yang.;Dongling Dai.
来源: BMC Gastroenterol. 2025年25卷1期617页
The newly proposed metabolic-associated fatty liver disease (MAFLD) definition better reflects the metabolic pathogenesis shared with non-alcoholic fatty liver disease (NAFLD), though with incomplete diagnostic overlap; this study systematically compares their prevalence and risk profiles in U.S. adolescents to inform optimal clinical management strategies.
9. Investigating the relationship between Helicobacter pylori and intestinal Clostridioides difficile infection: evidence from a cross-sectional study.
作者: Linlin Yin.;Hongfei Tu.;Yue Zhu.;Jingjing Qian.;Yang Yang.;Chen Wei.;Chengliang Ding.;Bin Zhang.
来源: BMC Gastroenterol. 2025年25卷1期616页
Helicobacter pylori (H. pylori) infection in the stomach can lead to alterations in the gut microbiota. However, the association between H. pylori infection and Clostridioides difficile infection (CDI) remains unclear.
12. Comparative outcomes of ERAS and conventional methods in laparoscopic sleeve gastrectomy: a 5-Year prospective cohort study in Saudi Arabia.
作者: Hager Aref.;Tahir Yunus.;Moheyeldin Farghaly.;Yasser ElDahshan.;Haseeb Javed Khan.;Dalia Alsaadi.;Francis Albert A Jacobo.;Ayan Ahmed.;Amel Mohamed.;Ali Y Saber.;Khairia Ali.;Farah Alefranji.;Edilberta Miranda.;Omar Dakkak.
来源: BMC Gastroenterol. 2025年25卷1期615页
The burden of obesity in Saudi Arabia is partly addressed with Laparoscopic Sleeve Gastrectomy (LSG), a bariatric surgical option, but perioperative complications and prolonged hospital stays persist. Enhanced Recovery After Surgery (ERAS) aims to improve postoperative outcomes.
13. Association between GLP-1 receptor agonists as a class and colorectal cancer risk: a meta-analysis of retrospective cohort studies.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in the management of type 2 diabetes mellitus (T2DM) and obesity. While these medications offer glycemic control and cardiovascular benefits, the risks have increased because of their potential impact on cancer risk, particularly colorectal cancer (CRC). This meta-analysis aimed to evaluate the association between GLP-1 RAs and CRC risk in patients receiving GLP-1 RAs.
14. Mechanism of NOTCH2 in promoting intrahepatic bile duct development.
作者: Chen Dong.;Sheng-Xuan Liu.;Biao Zou.;Sai-Nan Shu.;Ben-Ping Zhang.
来源: BMC Gastroenterol. 2025年25卷1期612页
The Notch signaling pathway plays a crucial role in intrahepatic bile duct development. Here, we aimed to investigate the effect of the Notch receptor, NOTCH2, on intrahepatic bile duct development to better understand congenital intrahepatic bile duct dysplasia.
15. Mycophenolate mofetil versus azathioprine as a first-line treatment for autoimmune hepatitis: a comparative systematic review and meta-analysis.
Autoimmune hepatitis (AIH) is a chronic progressive inflammatory liver disease of immune-mediated origin, which causes long-term liver inflammation and damage. Traditionally, treatment includes azathioprine (AZA) combined with steroids, but recent studies have highlighted mycophenolate mofetil (MMF) as a potential alternative, particularly for patients who do not respond well to AZA.
17. The effectiveness of radiotherapy and transarterial embolization for advanced gastric cancer bleeding.
作者: Yuki Ushimaru.;Ryohei Kawabata.;Kazuhiro Nishikawa.;Tomohira Takeoka.;Hiroshi Ikeda.;Yutaka Kimura.;Junya Fujita.;Yoichi Makari.;Akihiro Kitagawa.;Nobuyoshi Ohara.;Hideo Tomihara.;Sakae Maeda.;Mitsunobu Imasato.;Shingo Noura.;Atsushi Miyamoto.
来源: BMC Gastroenterol. 2025年25卷1期608页
Advanced gastric cancer frequently leads to severe complications, such as bleeding, which severely impacts patients' quality of life and prognosis. Traditional approaches for hemostasis include endoscopic treatments and surgery, but their invasive nature and potential for significant morbidity have made less invasive options like radiation therapy (RT) and transarterial embolization (TAE) appealing. Nonetheless, studies comparing the therapeutic effects and prognosis of RT and TAE are limited, underscoring a significant gap in research and clinical practice.
18. Efficacy and safety of programmed death-1 inhibitors combined with chemotherapy in patients with advanced gastric cancer.
作者: Xiaofei Cheng.;Yang Zhang.;Xingyuan Li.;Zhenning Xu.;Yaolin Chen.
来源: BMC Gastroenterol. 2025年25卷1期609页
Programmed death-1 (PD-1) inhibitors combined with chemotherapy show certain clinical benefits in advanced gastric cancer patients, but more evidence is still needed. The present study aimed to investigate the efficacy and safety of PD-1 inhibitors combined with chemotherapy in these patients.
19. The short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease.
作者: Ke Cao.;Zhiwei Zhai.;Xuyin Shi.;Yin Jin.;Chunxiang Ye.;Yunlong Wu.;Mingyu Sun.;Jing Wang.;Zhenjun Wang.;Jiagang Han.
来源: BMC Gastroenterol. 2025年25卷1期611页
While laparoscopic sleeve gastrectomy (LSG) is an established bariatric procedure for obesity, postoperative gastroesophageal reflux disease (GERD) remains a significant complication. This study evaluates the short-term efficacy of a novel technique combining LSG with acute angle of His reconstruction (LSG-His) versus conventional LSG.
20. Clinical anastomosis leakage and determinant factors among patients who underwent intestinal anastomosis in two Ethiopian tertiary hospitals.
作者: Yilkal Teshome Numaro.;Molla Asnake Kebede.;Shimelis Nigussie G Mariam.;Nelbyou Seyoum Abebe.;Bizuayehu Tassew Gossaye.;Sebsibe Dingetu Shenga.;Hezron Adinew Addi.;Melkamu Mitikie Melak.;Turi Abateka Abadiga.;Henok Birhanu Kassa.
来源: BMC Gastroenterol. 2025年25卷1期610页
Intestinal anastomosis is a common surgical procedure, but anastomotic leaks remain significant postoperative complications, causing morbidity, prolonged hospital stays, and readmissions. This study aimed to identify the rate, determinant factors, and outcomes associated with anastomotic leakage for patients undergo gastrointestinal anastomoses in two major hospitals in Addis Ababa, Ethiopia.
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