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2. Hypoxic Burden is Associated with Cardiovascular Events: A Risk Stratification Analysis of the RICCADSA Cohort.
作者: Yüksel Peker.;Yeliz Celik.;Andrey Zinchuk.;Scott A Sands.;Susan Redline.;Ali Azarbarzin.
来源: Chest. 2025年
The Apnea-Hypopnea Index (AHI), the standard measure of obstructive sleep apnea (OSA), has limitations in reflecting disease severity.
3. Contemporary Trends in Pediatric Extubation Failure and Non-Invasive Respiratory Support Use.
作者: Jeremy M Loberger.;Mitchell Moore.;Matthew Scanlon.;Robinder G Khemani.;Samer Abu-Sultaneh.;Colin M Rogerson.
来源: Chest. 2025年
Prolonged invasive mechanical ventilation is associated with morbidity and mortality in children. Timely extubation is essential and must balance the competing risks of extubation failure (EF) and prolonged use of post-extubation non-invasive respiratory support.
4. Geographical Distribution of Phase II/III Pharmaceutical Randomised Controlled Trials in Adults with Interstitial Lung Disease.
作者: Mingkun Guan.;Emma Marshall.;Sadhana Sughesh.;Hong Ye.;Christopher J Ryerson.;Yet H Khor.
来源: Chest. 2025年
Pharmaceutical randomised controlled trials (RCTs) are critical for advancing treatments in interstitial lung disease (ILD). We evaluated global distribution of pharmaceutical RCTs of ILD and their associations with country-specific features.
5. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure.
作者: Jose Victor Jimenez.;Lingxiao Zhang.;Zhenqiu Lin.;Lauren E Ferrante.;Jason R Falvey.;Allan J Walkey.;Harlan M Krumholz.;Snigdha Jain.
来源: Chest. 2025年
Older adults with socioeconomic disadvantage suffer greater decline in function and cognition following critical illness, an adverse outcome potentially preventable through mobilization. Whether safety-net hospitals (SNHs) that serve the highest proportions of patients with socioeconomic disadvantage are less likely to deliver rehabilitation during hospitalization with stay in the intensive care unit (ICU) is unknown.
6. Mortality Outcomes and ACE Inhibitor Use in Patients with Idiopathic Pulmonary Fibrosis.
作者: Burcu Ozaltin.;Robert Chapman.;Tine Follet.;Marie Vermant.;Muhammad Qummer Ul Arfeen.;Natalie Fitzpatick.;Harry Hemingway.;Wim Wuyts.;Kenan Direk.;Joseph Jacob.
来源: Chest. 2025年
ACE inhibitors (ACEi) are widely used antihypertensive agents with proven cardioprotective effects. Previous mechanistic and clinical studies have suggested ACEi therapy may slow disease progression and reduce mortality in idiopathic pulmonary fibrosis (IPF).
19. A 67-Year-Old Woman With Unexplained Nocturnal Hypoxemia.
作者: Kaveh Gaynor-Sodeifi.;Erin Eschbach.;David M Rapoport.;Vaishnavi Kundel.
来源: Chest. 2025年168卷2期e39-e43页
A 67-year-old woman presents for a second opinion for insomnia. She reports falling asleep with ease but difficulty maintaining sleep, with several nighttime awakenings. She has previously undergone cognitive behavioral therapy for insomnia without any improvement in her symptoms. She denies snoring and witnessed apneas but reports occasional daytime sleepiness, with an Epworth Sleepiness Score of 11 out of 24, indicating significant sleepiness. The remainder of her sleep history is unremarkable. Additionally, she has a medical history of anxiety, depression, and chronic pain, which is managed with aripiprazole, bupropion, clonazepam (as needed), and gabapentin. Her surgical history is pertinent for a tonsillectomy at age 5.
20. A 47-Year-Old Female With a Tubular, Nonenhancing Structure in the Left Lower Lobe.
A 47-year-old woman presented to the emergency department with sudden-onset dull nonradiating chest pain and palpitations. She denied other symptoms such as shortness of breath, dizziness, or diaphoresis. Her medical history was significant for generalized anxiety disorder, obesity, and former tobacco use (less than 1 pack per day for 5 years, quit more than 20 years ago). Her only medications included daily multivitamins and ibuprofen as needed for knee pain.
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