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1. Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD.
作者: Frank G Holz.;Yannick Le Mer.;Mahiul M K Muqit.;Lars-Olof Hattenbach.;Andrea Cusumano.;Salvatore Grisanti.;Laurent Kodjikian.;Marco Andrea Pileri.;Frederic Matonti.;Eric Souied.;Boris V Stanzel.;Peter Szurman.;Michel Weber.;Karl Ulrich Bartz-Schmidt.;Nicole Eter.;Marie Noelle Delyfer.;Jean François Girmens.;Koen A van Overdam.;Armin Wolf.;Ralf Hornig.;Martina Corazzol.;Frank Brodie.;Lisa Olmos de Koo.;Daniel Palanker.;José-Alain Sahel.
来源: N Engl J Med. 2025年
Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in such persons currently exist. The photovoltaic retina implant microarray (PRIMA) system combines a subretinal photovoltaic implant and glasses that project near-infrared light to the implant in order to restore sight to areas of central retinal atrophy.
2. Permethrin-Treated Baby Wraps for the Prevention of Malaria.
作者: Ross M Boyce.;Bonnie E Shook-Sa.;Ronnie Ndizeye.;Emmanuel Baguma.;Dana Giandomenico.;Caitlin A Cassidy.;Solomon Eshun.;Mark J Siedner.;Sarah G Staedke.;Moses Ntaro.;Jonathan J Juliano.;Raquel Reyes.;Edgar M Mulogo.
来源: N Engl J Med. 2025年393卷14期1399-1408页
Malaria remains a major cause of childhood death in sub-Saharan Africa. We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating the wraps with an insect repellent might provide a layer of protection against malaria.
3. Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk.
作者: Rebecca Smith-Bindman.;Susan A Alber.;Marilyn L Kwan.;Priscila Pequeno.;Wesley E Bolch.;Erin J A Bowles.;Robert T Greenlee.;Natasha K Stout.;Sheila Weinmann.;Lisa M Moy.;Carly Stewart.;Melanie Francisco.;Cameron Kofler.;James R Duncan.;Jonathan Ducore.;Malini Mahendra.;Jason D Pole.;Diana L Miglioretti.
来源: N Engl J Med. 2025年393卷13期1269-1278页
Assessing the risk of radiation-induced hematologic cancer from medical imaging in children and adolescents might support informed decisions on the use of imaging.
4. Introduction of Mpox Virus Clade Ib into the Republic of the Congo.
作者: Félix Koukouikila-Koussounda.;Claude Kwe Yinda.;Pembe I Mayengue.;Reiche G Elenga.;Dachel A E Boussam.;Ghislain D Indolo.;Lucette N Macosso.;Vincent J Munster.;Fabien R Niama.
来源: N Engl J Med. 2025年393卷11期1135-1137页 5. Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia.
作者: Jared Treverton.;Donald M Arnold.;Daniil G Ivanov.;Nikola Ivetic.;Yi Zhang.;Hossam A Ali.;Rumi Clare.;Igor A Kaltashov.;John G Kelton.;Ishac Nazy.
来源: N Engl J Med. 2025年393卷9期879-886页
Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a polyclonal immune response; however, studies of other rare anti-PF4 disorders have identified clonally restricted antibodies.
6. Home-Based Care for Hypertension in Rural South Africa.
作者: Mark J Siedner.;Nombulelo Magula.;Lusanda Mazibuko.;Nsika Sithole.;Alison Castle.;Siyabonga Nxumalo.;Thabang Manyaapelo.;Shafika Abrahams-Gessel.;Dickman Gareta.;Joanna Orne-Gliemann.;Kathy Baisley.;Max Bachmann.;Thomas A Gaziano.
来源: N Engl J Med. 2025年393卷13期1304-1314页
Poorly controlled hypertension is a common problem worldwide, particularly in low-resource settings.
7. Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension.
作者: John M Flack.;Michel Azizi.;Jenifer M Brown.;Jamie P Dwyer.;Jakub Fronczek.;Erika S W Jones.;Daniel S Olsson.;Shira Perl.;Hirotaka Shibata.;Ji-Guang Wang.;Ulrica Wilderäng.;Janet Wittes.;Bryan Williams.; .
来源: N Engl J Med. 2025年393卷14期1363-1374页
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pressure of patients with uncontrolled or resistant hypertension.
8. Beta-Blockers after Myocardial Infarction in Patients without Heart Failure.
作者: John Munkhaugen.;Anna Meta D Kristensen.;Sigrun Halvorsen.;Therese Holmager.;Michael Hecht Olsen.;Arnhild Bakken.;Thomas S G Sehested.;Vidar Ruddox.;Michael Mæng.;Kjell Vikenes.;Svend E Jensen.;Terje Steigen.;Jess Lambrechtsen.;Jarle Jortveit.;Ann Bovin.;Henrik Schirmer.;Morten Krogh Christiansen.;Rune Wiseth.;Dennis Mikkelsen.;Alf Inge Larsen.;Camilla Lyngby Kjærgaard.;Kristoffer Andresen.;Ida Gustafsson.;Vegard Tuseth.;Mogens Lytken Larsen.;Peter Stefan Deeg.;Karsten Veien.;Ellen Bøhmer.;Hans Erik Bøtker.;Anja Otrebska Brattrud.;Jens Brønnum-Schou.;Alf-Åge Reistad Pettersen.;Lia Evi Bang.;Erik Øie.;Thomas Engstrøm.;Eva Bostad Borg.;Kjeld Kristensen.;Ståle Haugset Nymo.;Gunnar Gislason.;Nils Tore Vethe.;Jawdat Abdul Majid Abdulla.;Toril Dammen.;Mette Rauhe Mouridsen.;Bjørn Bendz.;Mette Lykke Norgaard Bertelsen.;Jens Dahlgaard Hove.;Louise Schierbeck.;Martin Snoer.;Cedric Davidsen.;Gro Egholm.;Kristian Korsgaard Thomsen.;Ghassan Jadou.;Monica Poenaru.;Nikolaj Thure Krarup.;Morten Böttcher.;Peter Bisgaard Stæhr.;Ann-Dorthe Zwisler.;Thor Edvardsen.;Christian Torp-Pedersen.;Jan Erik Otterstad.;Theis Lange.;Morten W Fagerland.;Dan Atar.;Eva Prescott.; .
来源: N Engl J Med. 2025年
The evidence supporting beta-blocker therapy after myocardial infarction was established before the introduction of modern coronary reperfusion therapy and secondary prevention strategies.
9. Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy.
作者: Adolfo Aleman.;Oliver Van Oekelen.;David T Melnekoff.;Leah Grossman.;Tarek H Mouhieddine.;Agata Kurowski.;Ivan Odak.;Sidorela Reci.;Shriya Desai.;Shannon Meledathu.;Malini P Naidu.;Ravi P Shukla.;Rudra P Dutta.;Katerina Kappes.;Kseniya Serebryakova.;Hayley Jackson.;Jordan Lu.;Anastasia Chatikhine.;Raksha Kulkarni.;Zahra Moinfar.;Matthew M Croken.;Meenakshi Mehrotra.;Brett Baskovich.;Sampanna Rayamajhi.;Shambavi Richard.;Adriana C Rossi.;Christian Salib.;Jane Houldsworth.;Brian D Brown.;Miriam Merad.;Alessandro Laganà.;Patrick M Brunner.;Sundar Jagannath.;Joshua D Brody.;Samir Parekh.
来源: N Engl J Med. 2025年393卷8期823-825页 11. Ciprofloxacin versus Aminoglycoside-Ciprofloxacin for Bubonic Plague.
作者: Rindra Vatosoa Randremanana.;Mihaja Raberahona.;Josephine Bourner.;Minoarisoa Rajerison.;Tansy Edwards.;Ravaka Randriamparany.;Tsinjo Fehizoro Razafindratsinana.;Lisy Hanitra Razananaivo.;Gabriella Zadonirina.;Théodora Mayouya-Gamana.;Alex Paddy Abdel Salam.;Reziky Tiandraza Mangahasimbola.;Voahangy Andrianaivoarimanana.;Elise Pesonel.;Rivonirina Andry Rakotoarivelo.;Mamy Jean de Dieu Randria.;Peter Horby.;Piero Olliaro.; .
来源: N Engl J Med. 2025年393卷6期544-555页
Plague is a high-consequence infectious disease with epidemic potential. Current treatment guidelines are based on weak evidence.
12. Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling.
作者: Peiying Ye.;Jenna R E Bergerson.;Isaac Brownell.;Gabriel J Starrett.;Roshini S Abraham.;Megan V Anderson.;Triscia Martin.;Derek MacMath.;Hye Sun Kuehn.;Jyothi Padiadpu.;Siqi Zhao.;Sergio D Rosenzweig.;Roxane Tussiwand.;Warren J Leonard.;Stefania Pittaluga.;Mark Raffeld.;Danielle E Arnold.;Andrea Lisco.
来源: N Engl J Med. 2025年393卷5期469-478页
Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is dispensable for the maintenance of cutaneous SCC. Here, we describe a woman with benign and malignant HPV-related diseases that include a recurrent, unresectable, invasive cutaneous SCC with β-HPV19 genomic integration in the context of germline pathogenic mutations in ZAP70, an adapter required for T-cell receptor (TCR) signal transduction. Restoration of the integrity of TCR signaling by allogeneic hematopoietic-cell transplantation led to the resolution of all HPV-related diseases, thereby revealing a direct role of β-HPV in skin carcinogenesis in hosts with defective adaptive T-cell responses. (Funded by the National Institutes of Health.).
13. Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease.
作者: Robert McFarland.;Louise A Hyslop.;Catherine Feeney.;Rekha N Pillai.;Emma L Blakely.;Eilis Moody.;Matthew Prior.;Anita Devlin.;Robert W Taylor.;Mary Herbert.;Meenakshi Choudhary.;Jane A Stewart.;Douglass M Turnbull.
来源: N Engl J Med. 2025年393卷5期461-468页
Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathogenic mtDNA variants with reproductive options. A total of 22 women with pathogenic mtDNA variants have commenced or completed pronuclear transfer (and thus receipt of a mitochondrial donation), and there have been 8 live births. All 8 children were healthy at birth, with no or low levels of mtDNA heteroplasmy in blood. Hyperlipidemia and cardiac arrhythmia developed in a child whose mother had hyperlipidemia during pregnancy; both of the child's conditions responded to treatment. Infant myoclonic epilepsy developed in another child, with spontaneous remission. At the time of this report, all the children have made normal developmental progress. (Funded by the U.K. National Health Service and others.).
14. Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease.
作者: Louise A Hyslop.;Emma L Blakely.;Magomet Aushev.;Jordan Marley.;Yuko Takeda.;Angela Pyle.;Eilis Moody.;Catherine Feeney.;Jan Dutton.;Carol Shaw.;Sarah J Smith.;Kate Craig.;Charlotte L Alston.;Lisa Lister.;Karina Endacott.;Samantha Byerley.;Helen McDermott.;Kathryn Wilson.;Lynne Botham.;Beth Matthew.;Nilendran Prathalingam.;Matthew Prior.;Alison Murdoch.;Douglass M Turnbull.;Gavin Hudson.;Meenakshi Choudhary.;Robert W Taylor.;Rekha N Pillai.;Jane A Stewart.;Robert McFarland.;Mary Herbert.
来源: N Engl J Med. 2025年393卷5期438-449页
Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuclear transfer involves transplantation of nuclear genome from a fertilized egg from the affected woman to an enucleated fertilized egg donated by an unaffected woman. Thus, pronuclear transfer offers affected women the potential to have a genetically related child with a reduced risk of mtDNA disease.
15. Monoclonal Anti-Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss.
作者: Natalie R Bavli.;Adam J Kanack.;Yoshito Nishimura.;Noah P Splinter.;Emily E Mauch.;Alessandra J Ainsworth.;Ravi Sarode.;Robert D McBane.;Mindy C Kohlhagen.;David Murray.;Dong Chen.;Rajiv K Pruthi.;Anand Padmanabhan.
来源: N Engl J Med. 2025年393卷3期306-309页 16. Phase 2a Study of Baxdrostat in Primary Aldosteronism.
作者: Adina F Turcu.;Mason W Freeman.;Irina Bancos.;Anat Ben-Shlomo.;Oksana Hamidi.;Amir H Hamrahian.;Wenyu Huang.;Lawrence S Kirschner.;Ramin Sam.;Ashwini Mallappa.;Bonifride Tuyishimire.;Aina S Lihn.;Shira Perl.;Morris J Brown.; .
来源: N Engl J Med. 2025年393卷5期515-518页 19. Three Cases of Vertical Transmission of Clade Ib Mpox Virus.
作者: Emmanuel Hasivirwe Vakaniaki.;Nono-Raymond Swar Kuispond.;Yuichiro Hirata.;Eugene Bangwen.;Isabel Brosius.;Eddy Kinganda-Lusamaki.;Seiya Ozono.;Harutaka Katano.;Laurent Gabanga Ndunge.;Noella Mulopo-Mukanya.;Jean-Claude Tshomba.;Elise De Vos.;Christophe Van Dijck.;Papy Munganga.;Guy Mukari.;Yves Mujula.;Divin Mazambi Mambo.;Steeven Bilembo Kitwanda.;Nadine Maliyamungu-Bubala.;Léandre Mutimbwa-Mambo.;Ian Crozier.;Lori E Dodd.;Olivier Tshiani-Mbaya.;Bienvenu Massamba Lebwaze.;Espoir Bwenge Malembaka.;Isaac Barhishindi.;Susanne Krasemann.;Robert Colebunders.;Patrick D M C Katoto.;Sheila Makiala-Mandanda.;Jason Kindrachuk.;Anne W Rimoin.;Jean-Jacques Muyembe-Tamfum.;Daniel Mukadi-Bamuleka.;Tony Wawina-Bokalanga.;Sabin Sabiti Nundu.;Tadaki Suzuki.;Raphaël Bulakali Chirimwami.;Laurens Liesenborghs.;Placide Mbala-Kingebeni.
来源: N Engl J Med. 2025年392卷23期2385-2387页 20. Measurable Residual Disease-Guided Therapy for Chronic Lymphocytic Leukemia.
作者: Talha Munir.;Sean Girvan.;David A Cairns.;Adrian Bloor.;David Allsup.;Abraham M Varghese.;Satyen Gohil.;Shankara Paneesha.;Andrew Pettitt.;Toby Eyre.;Christopher P Fox.;Francesco Forconi.;Ben Kennedy.;Constantine Balotis.;Nicholas Pemberton.;Oonagh Sheehy.;John Gribben.;Nagah Elmusharaf.;Simona Gatto.;Gavin Preston.;Anna Schuh.;Renata Walewska.;Lelia Duley.;Nichola Webster.;Surita Dalal.;Andrew Rawstron.;Dena Howard.;Anna Hockaday.;Sharon Jackson.;Natasha Greatorex.;Sue Bell.;David Stones.;Julia M Brown.;Piers E M Patten.;Peter Hillmen.; .
来源: N Engl J Med. 2025年393卷12期1177-1190页
An interim analysis of progression-free survival in this trial showed that ibrutinib-venetoclax was superior to fludarabine-cyclophosphamide-rituximab (FCR) among patients with chronic lymphocytic leukemia (CLL). Whether ibrutinib-venetoclax is more effective than ibrutinib alone is unclear.
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