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1701. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
作者: Dae Hyun Kim.;Su Been Lee.;Chan Mi Park.;Raisa Levin.;Eran Metzger.;Brian T Bateman.;E Wesley Ely.;Pratik P Pandharipande.;Margaret A Pisani.;Richard N Jones.;Edward R Marcantonio.;Sharon K Inouye.
来源: Ann Intern Med. 2023年176卷9期1153-1162页
Antipsychotics are commonly used to manage postoperative delirium. Recent studies reported that haloperidol use has declined, and atypical antipsychotic use has increased over time.
1702. Evidence-Based Cardiovascular Disease Medicines' Availability in Low-Cost Generic Drug Programs in the United States : A Cross-Sectional Study.
作者: Ivy T Ton.;Jungyeon Moon.;Anthony Sengul.;Freny Vaghaiwalla Mody.;Towhid Rahman.;Janet K Han.;Cynthia A Jackevicius.
来源: Ann Intern Med. 2023年176卷9期1190-1199页
Low-cost generic programs (LCGPs) that expand access to affordable cardiovascular disease (CVD) medicines can assist patients in achieving desired cardiovascular outcomes. It is important that LCGPs offer CVD medicines that promote evidence-based prescribing.
1703. In treatment-resistant major depression, ketamine was noninferior to ECT for treatment response.
Anand A, Mathew SJ, Sanacora G, et al. Ketamine versus ECT for nonpsychotic treatment-resistant major depression. N Engl J Med. 2023;388:2315-2325. 37224232.
1704. In moderate-to-severe Crohn disease, upadacitinib increased clinical remission at 12 and 52 wk.
Loftus EV Jr, Panés J, Lacerda AP, et al. Upadacitinib induction and maintenance therapy for Crohn's disease. N Engl J Med. 2023;388:1966-1980. 37224198.
1706. The 3D-CAM 3-minute interview has 92% sensitivity and 95% specificity for detecting delirium in various care settings.
Ma R, Zhao J, Li C, et al. Diagnostic accuracy of the 3-minute diagnostic interview for confusion assessment method-defined delirium in delirium detection: a systematic review and meta-analysis. Age Ageing. 2023;52:afad074. 37211364.
1708. In chronic HF, empagliflozin reduced a composite of CV death or HF hospitalization across kidney risk categories.
Butler J, Packer M, Siddiqi TJ, et al. Efficacy of empagliflozin in patients with heart failure across kidney risk categories. J Am Coll Cardiol. 2023;81:1902-1914. 37164523.
1709. In HF, with or without PAD, dapagliflozin reduced a composite of worsening HF or CV death and did not increase amputations.
Butt JH, Kondo T, Yang M, et al. Heart failure, peripheral artery disease, and dapagliflozin: a patient-level meta-analysis of DAPA-HF and DELIVER. Eur Heart J. 2023;44:2170-2183. 37220172.
1710. In adults with cancer and VTE, DOACs were noninferior to LMWH for recurrent, nonfatal VTE at 6 mo.
Schrag D, Uno H, Rosovsky R, et al; CANVAS Investigators. Direct oral anticoagulants vs low-molecular-weight heparin and recurrent VTE in patients with cancer: a randomized clinical trial. JAMA. 2023;329:1924-1933. 37266947.
1711. SGLT2 inhibitors improved health status in Black and White patients with HF regardless of race.
Gupta K, Spertus JA, Birmingham M, et al. Racial differences in quality of life in patients with heart failure treated with sodium-glucose cotransporter 2 inhibitors: a patient-level meta-analysis of the CHIEF-HF, DEFINE-HF, and PRESERVED-HF trials. Circulation. 2023;148:220-228. 37191040.
1712. CTFPHC recommends risk assessment-first screening to prevent fragility fractures in women aged ≥65 y.
Thériault G, Limburg H, Klarenbach S, et al; Canadian Task Force on Preventive Health Care. Recommendations on screening for primary prevention of fragility fractures. CMAJ. 2023;195:E639-E649. 37156553.
1713. In older adults with frailty, virtual reality exercise training improves walking speed and balance.
Lee YH, Lin CH, Wu WR, et al. Virtual reality exercise programs ameliorate frailty and fall risks in older adults: a meta-analysis. J Am Geriatr Soc. 2023 May 10. [Epub ahead of print.] 37165743.
1714. In COPD with type 2 inflammation despite inhaled triple therapy, dupilumab safely reduced exacerbations.
Bhatt SP, Rabe KF, Hanania NA, et al; BOREAS Investigators. Dupilumab for COPD with type 2 inflammation indicated by eosinophil counts. N Engl J Med. 2023;389;205-214.37272521.
1715. Standards and Ethics Issues in the Determination of Death: A Position Paper From the American College of Physicians.
The determination of a patient's death is of considerable medical and ethical significance. Death is a biological concept with social implications. Acting with honesty, transparency, respect, and integrity is critical to trust in the patient-physician relationship, and the profession, in life and in death. Over time, cases about the determination of death have raised questions that need to be addressed. This American College of Physicians position paper addresses current controversies and supports a clarification to the Uniform Determination of Death Act; maintaining the 2 current independent standards of determining death, cardiorespiratory and neurologic; retaining the whole brain death standard; aligning medical testing with the standards; keeping issues about the determination of death separate from organ transplantation; reaffirming the importance and role of the dead donor rule; and engaging in educational efforts for health professionals, patients, and the public on these issues. Physicians should advocate for policies and practices on the determination of death that are consistent with the profession's fundamental and timeless commitment to individual patients and the public.
1718. Role of Artificial Intelligence in Colonoscopy Detection of Advanced Neoplasias : A Randomized Trial.
作者: Carolina Mangas-Sanjuan.;Luisa de-Castro.;Joaquín Cubiella.;Pilar Díez-Redondo.;Adolfo Suárez.;María Pellisé.;Nereida Fernández.;Sara Zarraquiños.;Henar Núñez-Rodríguez.;Verónica Álvarez-García.;Oswaldo Ortiz.;Noelia Sala-Miquel.;Pedro Zapater.;Rodrigo Jover.; .
来源: Ann Intern Med. 2023年176卷9期1145-1152页
The role of computer-aided detection in identifying advanced colorectal neoplasia is unknown.
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