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123. Ventilatory Efficiency in Transgender Women: Implications of Gender-Affirming Hormone Therapy for Cardiorespiratory Responses.
作者: Fabrício Braga.;Mauricio Milani.;Ana Carolina Fachetti.;Bruna Kalichsztein.;Gabriel Espinosa.;Fernanda Domecg.;Roberto Zagury.;Karen De Marca.;Rossano Fiorelli.;Dominique Hansen.;Gerson Cipriano.;Ricardo Mourilhe-Rocha.
来源: Chest. 2025年
Ventilatory efficiency, a key parameter of cardiopulmonary function assessed through cardiopulmonary exercise testing (CPET), often demonstrates significant variability in transgender women because of the physiological changes induced by gender-affirming hormone therapy. Understanding these differences is essential for optimizing clinical management and enhancing health outcomes within this population.
124. Association Between Airway Mucus Plugs and Risk of Moderate-to-Severe Exacerbations in Patients With COPD: Results From a Chinese Prospective Cohort Study.
作者: Xueping Li.;Shengchuan Feng.;Yuqiong Yang.;Zhenyu Liang.;Aiqi Song.;Jiawei Chen.;Zijun Guo.;Zizheng Chen.;Chengyu Miao.;Huajing Yang.;Wenqiang He.;Zifei Zhou.;M Brad Drummond.;Rongchang Chen.;Fengyan Wang.
来源: Chest. 2025年
Airway mucus plugs are frequently identified on CT scans of patients with COPD and are associated with worse airflow obstruction and higher mortality. However, the association between airway mucus plugs and the risk of acute exacerbation of COPD (AECOPD) has not been extensively studied.
125. Effect of Admilparant, an Lysophosphatidic Acid Receptor 1 Antagonist, on Disease Progression in Pulmonary Fibrosis.
作者: Michael Kreuter.;Toby M Maher.;Wim A Wuyts.;Claudia Valenzuela.;Mark Hamblin.;Sinae Kim.;Aditya Patel.;Brandon Elpers.;Luca Richeldi.
来源: Chest. 2025年
Idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) are chronic fibrosing interstitial lung diseases associated with irreversible loss of lung function and early mortality. Admilparant (BMS-986278) is an oral lysophosphatidic acid receptor 1 antagonist under development for treatment of IPF and PPF.
126. Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial.
作者: Kevin P Seitz.;Bradley D Lloyd.;Li Wang.;Matthew S Shotwell.;Edward T Qian.;Amelia L Muhs.;Roger K Richardson.;J Craig Rooks.;Vanessa Hennings-Williams.;Claire E Sandoval.;Whitney D Richardson.;Tracy L Morgan.;Amber N Thompson.;Pamela G Hastings.;Terry P Ring.;Joanna L Stollings.;Erica M Talbot.;David J Krasinski.;Bailey R DeCoursey.;Tanya K Marvi.;Stephanie C DeMasi.;Kevin W Gibbs.;Wesley H Self.;Amanda S Mixon.;Todd W Rice.;Matthew W Semler.;Jonathan D Casey.; .
来源: Chest. 2025年
Whether the choice of ventilator mode affects outcomes for critically ill patients is unknown.
127. Investigating the Long-Term Effects of COVID-19 Infection on Health Care Utilization in Individuals With COPD.
作者: Joseph Munn.;Peter Austin.;Clare Atzema.;Stacey Butler.;Candace McNaughton.;Xuesong Wang.;Andrea S Gershon.
来源: Chest. 2025年
Individuals with COPD are at elevated risk of severe outcomes following COVID-19 infection.
128. The Association Between Mechanical Power Within the First 24 Hours and ICU Mortality in Mechanically Ventilated Adult Patients With Acute Hypoxemic Respiratory Failure: A Registry-Based Cohort Study.
作者: Stephan von Düring.;Kuan Liu.;Laveena Munshi.;S Joseph Kim.;Martin Urner.;Neill K J Adhikari.;Ken Kuljit S Parhar.;Eddy Fan.
来源: Chest. 2025年
Despite the widespread adoption of lung-protective ventilation strategies, mortality among patients receiving invasive mechanical ventilation (IMV) remains high. Mechanical power (MP) integrates some variables responsible for ventilator-induced lung injury and has been associated with mortality in patients with ARDS. However, the impact of MP on ICU mortality in the larger group of patients with acute hypoxemic respiratory failure (AHRF) has not been well established, and previous studies have reported inconsistent thresholds for predicting outcomes.
129. Effects of the Combination of Pimavanserin and Atomoxetine on OSA Severity: A Randomized Crossover Trial.
作者: Ludovico Messineo.;Madison Preuss.;Ali Azarbarzin.;Daniel Vena.;Laura Gell.;Atqiya Aishah.;Neda Esmaeili.;Molly Kim.;Isabel Burdick.;Tom Chen.;David White.;Scott A Sands.;Andrew Wellman.
来源: Chest. 2025年
OSA pharmacologic interventions like the noradrenergic muscle stimulant atomoxetine have wake-promoting properties. Pimavanserin, a promising serotonin 2A receptor antagonist, may help to counteract atomoxetine's noradrenergic effects by increasing arousal threshold and possibly reducing OSA severity.
130. Bronchiectasis in Patients With Inflammatory Bowel Diseases: Prevalence, Predictors, and Clinical Characteristics.
作者: Ophir Freund.;Amir Bar-Shai.;Arik Alkhazov.;Dana Stav.;Yitzhac Hadad.;Tal Moshe Perluk.;Neta Sror.;Ayal Hirsch.;Yulia Ron.;Tamar Thurm.;Amit Herling.;Haim Leibovitzh.;Nitsan Maharshak.;Nathaniel Aviv Cohen.
来源: Chest. 2025年
Inflammatory bowel diseases (IBDs) are known to be associated with bronchiectasis (BE). However, data on patients IBD-related bronchiectasis (IBD-BE) are limited.
131. Timely Spirometry Is Associated With Lower All-Cause Mortality: A Nationwide Obstructive Cohort Study.
Although spirometry is the gold standard for diagnosing COPD, it is underused in clinical practice.
132. CT Emphysema Subtypes and Cardiac Hemodynamics Estimated on MRI: The Multi-Ethnic Study of Atherosclerosis COPD Study.
作者: Emilia A Hermann.;Jesse X Yang.;Elsa Angelini.;Pallavi Balte.;David A Bluemke.;James Carr.;Katja Derlin.;Antoinette S Gomes.;Mohammadali Habibi.;Eric A Hoffman.;Chris Johns.;Steven M Kawut.;David G Kiely.;Andrew Laine.;Joao A C Lima.;Martin R Prince.;Benjamin Smith.;Jens Vogel-Claussen.;Karol Watson.;Jim M Wild.;Andrew J Swift.;R Graham Barr.
来源: Chest. 2025年
COPD is traditionally associated with pulmonary hypertension, but treatments targeting elevated pulmonary artery pressure in COPD have largely failed, possibly due to an incomplete understanding of subphenotypes of the disease.
133. US Physicians' Perceived Impacts of Abortion Bans in Pulmonary and Critical Care Medicine.
作者: Katrina E Hauschildt.;Avnee J Kumar.;Elizabeth M Viglianti.;Kelly C Vranas.;Taylor Bernstein.;Leslie Moroz.;Theodore J Iwashyna.
来源: Chest. 2025年
Eighteen US states implemented abortion bans between 2022 and 2024. Although emerging evidence shows bans have impacted obstetrics and gynecology, little is known about their impact on other specialties. We hypothesize that pulmonary and critical care medicine may be adversely impacted due to the time-sensitive, high-acuity needs of their patients.
134. Accuracy of Pulse Oximetry and Risk Factors Associated With Discrepancy From Arterial Oxygenation in Asian Patients in the ICU: An Observational Study.
作者: Toshishige Takagi.;Tomoko Fujii.;Sae Nakamura.;Yusuke Tsutsumi.;Shoichi Uezono.
来源: Chest. 2025年
Oxygen administration is often guided by pulse oximeter readings. However, inaccuracies have been reported, particularly in patients with darker skin tones. During the COVID-19 pandemic, racial and ethnic disparities in hypoxemia detection emerged, with studies showing a higher incidence of hidden hypoxemia in Black and Hispanic patients. However, limited data exist regarding the Asian population.
135. Inhaled Menthol for Dyspnea Relief During Cycle Exercise in COPD: A Randomized Trial.
作者: Michele R Schaeffer.;Lucas Vanden Bossche.;Kaat Beckers.;Kristin Verbeke.;Wim Janssens.;Dennis Jensen.;Jem I Arnold.;Andreas von Leupoldt.;Daniel Langer.
来源: Chest. 2025年
Menthol inhalation (MI) lowers dyspnea ratings during loaded breathing in COPD and cycle exercise in healthy adults. Proposed mechanisms include stimulation of cold receptors in the upper airways, modulating perception of breathing-related effort, and airflow.
136. Low-Intensity vs Moderate-Intensity Anticoagulation for Venovenous Extracorporeal Membrane Oxygenation: The Strategies for Anticoagulation During Venovenous Extracorporeal Membrane Oxygenation Pilot Trial.
作者: Whitney D Gannon.;Elias H Pratt.;Melissa A Vogelsong.;Wren H Adkisson.;Matthew Bacchetta.;Sarah L Bloom.;Daniel J Ford.;Brandon A Guenthart.;Janna S Landsperger.;Edward T Qian.;Craig R Rackley.;Todd W Rice.;Vikram Fielding-Singh.;John W Stokes.;Joanna L Stollings.;Matthew W Semler.;Jonathan D Casey.; .
来源: Chest. 2025年
Bleeding is a common and sometimes fatal complication of venovenous extracorporeal membrane oxygenation (ECMO). Whether lowering the intensity of anticoagulation during venovenous ECMO is safe or effective is unknown.
138. Preserved Ratio Impaired Spirometry Findings and Immune Dysfunction Among Adolescents With and Without HIV in Kenya.
作者: Laura E Ellington.;Elizabeth Maleche-Obimbo.;Brandon L Guthrie.;Margaret Rosenfeld.;T Eoin West.;Christine J McGrath.;Judith Lukorito.;Christine Njiru.;Anthony Cagle.;Sherry Eskander.;Michael H Chung.;Kristina Crothers.;Engi F Attia.
来源: Chest. 2025年
Chronic lung disease and its association with immune dysfunction are characterized poorly among adolescents with HIV (AWHIVs).
139. Peripheral Airways Dysfunction Is a Major Contributor to Poor Quality of Life in Sarcoidosis.
作者: Dimitrios Toumpanakis.;Konstantinos Karagiannis.;Paolo Paredi.;Andras Bikov.;Martina Bonifazi.;Harpreet K Lota.;Harpal Kalsi.;Cosetta Minelli.;Nikolaos Dikaios.;George A Kastis.;Peter J Barnes.;Athol U Wells.;Omar S Usmani.;Elisabetta A Renzoni.
来源: Chest. 2025年
Sarcoidosis is characterized by reduced quality of life (QoL), yet QoL is correlated poorly to conventional spirometric lung function tests.
140. Phenotyping Exertional Breathlessness Using Cardiopulmonary Cycle Exercise Testing in People With Chronic Airflow Limitation.
作者: Magnus Ekström.;Pei Zhi Li.;Hayley Lewthwaite.;Jean Bourbeau.;Wan C Tan.;Dennis Jensen.; .
来源: Chest. 2025年
Exertional breathlessness is a cardinal symptom of people with chronic airflow limitation (CAL) and can be evaluated using cardiopulmonary exercise testing (CPET).
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