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1221. Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.
作者: Malin Fromme.;Carolin V Schneider.;Vitor Pereira.;Karim Hamesch.;Monica Pons.;Matthias C Reichert.;Federica Benini.;Paul Ellis.;Katrine H Thorhauge.;Mattias Mandorfer.;Barbara Burbaum.;Vivien Woditsch.;Joanna Chorostowska-Wynimko.;Jef Verbeek.;Frederik Nevens.;Joan Genesca.;Marc Miravitlles.;Alexa Nuñez.;Benedikt Schaefer.;Heinz Zoller.;Sabina Janciauskiene.;Nélia Abreu.;Luís Jasmins.;Rui Gaspar.;Rodrigo Liberal.;Guilherme Macedo.;Ravi Mahadeva.;Catarina Gomes.;Kai Markus Schneider.;Michael Trauner.;Aleksander Krag.;Bibek Gooptu.;Douglas Thorburn.;Aileen Marshall.;John R Hurst.;David A Lomas.;Frank Lammert.;Nadine T Gaisa.;Virginia Clark.;William Griffiths.;Christian Trautwein.;Alice M Turner.;Noel G McElvaney.;Pavel Strnad.
来源: Gut. 2022年71卷2期415-423页
Alpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn disorder caused by mutations in alpha-1 antitrypsin (AAT). Homozygosity for the 'Pi*Z' variant of AAT (Pi*ZZ genotype) causes lung and liver disease, whereas heterozygous 'Pi*Z' carriage (Pi*MZ genotype) predisposes to gallstones and liver fibrosis. The clinical significance of the more common 'Pi*S' variant remains largely undefined and no robust data exist on the prevalence of liver tumours in AATD.
1222. Risks of post-colonoscopic polypectomy bleeding and thromboembolism with warfarin and direct oral anticoagulants: a population-based analysis.
作者: Louis Hs Lau.;Cosmos Lt Guo.;Terry Cf Yip.;Joyce Wy Mak.;Sunny H Wong.;Kelvin Ly Lam.;Grace Lh Wong.;Siew C Ng.;Francis Kl Chan.
来源: Gut. 2022年71卷1期100-110页
There were limited data on the risk of post-polypectomy bleeding (PPB) in patients on direct oral anticoagulants (DOAC). We aimed to evaluate the PPB and thromboembolic risks among DOAC and warfarin users in a population-based cohort.
1224. Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial.
作者: Geltrude Mingrone.;Annieke Cg van Baar.;Jacques Devière.;David Hopkins.;Eduardo Moura.;Cintia Cercato.;Harith Rajagopalan.;Juan Carlos Lopez-Talavera.;Kelly White.;Vijeta Bhambhani.;Guido Costamagna.;Rehan Haidry.;Eduardo Grecco.;Manoel Galvao Neto.;Guruprasad Aithal.;Alessandro Repici.;Bu'Hussain Hayee.;Amyn Haji.;A John Morris.;Raf Bisschops.;Manil D Chouhan.;Naomi S Sakai.;Deepak L Bhatt.;Arun J Sanyal.;J J G H M Bergman.; .
来源: Gut. 2022年71卷2期254-264页
Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR (catheter and system)), on glycaemic control and liver fat content in type 2 diabetes (T2D).
1225. Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia.
作者: Matthieu Rouland.;Lucie Beaudoin.;Ophélie Rouxel.;Léo Bertrand.;Lucie Cagninacci.;Azadeh Saffarian.;Thierry Pedron.;Dalale Gueddouri.;Sandra Guilmeau.;Anne-Françoise Burnol.;Latif Rachdi.;Asmaa Tazi.;Juliette Mouriès.;Maria Rescigno.;Nathalie Vergnolle.;Philippe Sansonetti.;Ute Christine Rogner.;Agnès Lehuen.
来源: Gut. 2022年71卷2期296-308页
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β-cells producing insulin. Both T1D patients and animal models exhibit gut microbiota and mucosa alterations, although the exact cause for these remains poorly understood. We investigated the production of key cytokines controlling gut integrity, the abundance of segmented filamentous bacteria (SFB) involved in the production of these cytokines, and the respective role of autoimmune inflammation and hyperglycaemia.
1226. Oncogenetic landscape of lymphomagenesis in coeliac disease.
作者: Sascha Cording.;Ludovic Lhermitte.;Georgia Malamut.;Sofia Berrabah.;Amélie Trinquand.;Nicolas Guegan.;Patrick Villarese.;Sophie Kaltenbach.;Bertrand Meresse.;Sherine Khater.;Michael Dussiot.;Marc Bras.;Morgane Cheminant.;Bruno Tesson.;Christine Bole-Feysot.;Julie Bruneau.;Thierry Jo Molina.;David Sibon.;Elizabeth Macintyre.;Olivier Hermine.;Christophe Cellier.;Vahid Asnafi.;Nadine Cerf-Bensussan.; .
来源: Gut. 2022年71卷3期497-508页
Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of coeliac disease (CeD), often preceded by low-grade clonal intraepithelial lymphoproliferation, referred to as type II refractory CeD (RCDII). Knowledge on underlying oncogenic mechanisms remains scarce. Here, we analysed and compared the mutational landscape of RCDII and EATL in order to identify genetic drivers of CeD-associated lymphomagenesis.
1227. Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.
作者: Xiaoting Sun.;Xingkang He.;Yin Zhang.;Kayoko Hosaka.;Patrik Andersson.;Jing Wu.;Jieyu Wu.;Xu Jing.;Qiqiao Du.;Xiaoli Hui.;Bo Ding.;Ziheng Guo.;An Hong.;Xuan Liu.;Yan Wang.;Qing Ji.;Rudi Beyaert.;Yunlong Yang.;Qi Li.;Yihai Cao.
来源: Gut. 2022年71卷1期129-147页
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy.
1228. Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.
作者: Marianne Rebecca Spalinger.;Ali Shawki.;Pritha Chatterjee.;Vinicius Canale.;Alina Santos.;Anica Sayoc-Becerra.;Michael Scharl.;Michel L Tremblay.;James Borneman.;Declan F McCole.
来源: Gut. 2022年71卷1期89-99页
Alterations in the intestinal microbiota are linked with a wide range of autoimmune and inflammatory conditions, including inflammatory bowel diseases (IBD), where pathobionts penetrate the intestinal barrier and promote inflammatory reactions. In patients with IBD, the ability of intestinal macrophages to efficiently clear invading pathogens is compromised resulting in increased bacterial translocation and excessive immune reactions. Here, we investigated how an IBD-associated loss-of-function variant in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene, or loss of PTPN2 expression affected the ability of macrophages to respond to invading bacteria.
1229. Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma.
作者: Camille Péneau.;Sandrine Imbeaud.;Tiziana La Bella.;Theo Z Hirsch.;Stefano Caruso.;Julien Calderaro.;Valerie Paradis.;Jean-Frederic Blanc.;Eric Letouzé.;Jean-Charles Nault.;Giuliana Amaddeo.;Jessica Zucman-Rossi.
来源: Gut. 2022年71卷3期616-626页
Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC) worldwide. HBV directly drives carcinogenesis through integrations in the human genome. This study aimed to precisely characterise HBV integrations, in relation with viral and host genomics and clinical features.
1231. Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?
作者: Ramy Younes.;Olivier Govaere.;Salvatore Petta.;Luca Miele.;Dina Tiniakos.;Alastair Burt.;Ezio David.;Fabio Maria Vecchio.;Marco Maggioni.;Daniela Cabibi.;Duncan McLeod.;Maria Jesus Pareja.;Anna Ludovica Fracanzani.;Rocio Aller.;Chiara Rosso.;Javier Ampuero.;Rocío Gallego-Durán.;Angelo Armandi.;Gian Paolo Caviglia.;Marco Y W Zaki.;Antonio Liguori.;Paolo Francione.;Grazia Pennisi.;Antonio Grieco.;Giovanni Birolo.;Piero Fariselli.;Mohammed Eslam.;Luca Valenti.;Jacob George.;Manuel Romero-Gómez.;Quentin Mark Anstee.;Elisabetta Bugianesi.
来源: Gut. 2022年71卷2期382-390页
The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD.
1232. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
作者: Ane Olazagoitia-Garmendia.;Linda Zhang.;Paula Mera.;Julie K Godbout.;Maialen Sebastian-DelaCruz.;Iraia Garcia-Santisteban.;Luis Manuel Mendoza.;Alain Huerta.;Iñaki Irastorza.;Govind Bhagat.;Peter H Green.;Laura Herrero.;Dolors Serra.;Jose Antonio Rodriguez.;Elena F Verdu.;Chuan He.;Jose Ramon Bilbao.;Ainara Castellanos-Rubio.
来源: Gut. 2022年71卷1期68-76页
Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet. Human leucocyte antigen (HLA) genes and several non-HLA regions have been associated with the genetic susceptibility to CD, but their role in the pathogenesis of the disease is still essentially unknown, making it complicated to develop much needed non-dietary treatments. Here, we describe the functional involvement of a CD-associated single-nucleotide polymorphism (SNP) located in the 5'UTR of XPO1 in the inflammatory environment characteristic of the coeliac intestinal epithelium.
1233. Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
作者: Lena Allweiss.;Katja Giersch.;Andrea Pirosu.;Tassilo Volz.;Robert C Muench.;Rudolf K Beran.;Stephan Urban.;Hassan Javanbakht.;Simon P Fletcher.;Marc Lütgehetmann.;Maura Dandri.
来源: Gut. 2022年71卷2期372-381页
Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-IFNα) on the viral regulatory HBx protein and the structural maintenance of chromosome 5/6 complex (SMC5/6), a host factor suppressing cccDNA transcription. In particular, we assessed whether interventions lowering HBV transcripts can achieve and maintain silencing of cccDNA transcription in vivo.
1234. Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut-testis axis.
作者: Teng Zhang.;Peng Sun.;Qi Geng.;Haitao Fan.;Yutian Gong.;Yanting Hu.;Liying Shan.;Yuanchao Sun.;Wei Shen.;Yang Zhou.
来源: Gut. 2022年71卷1期78-87页
Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut-testis axis in the aetiology of impaired spermatogenesis.
1235. Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.
作者: Jonel Trebicka.;Wenyi Gu.;Victor de Ledinghen.;Christophe Aubé.;Aleksander Krag.;Michael Praktiknjo.;Laurent Castera.;Jerome Dumortier.;David Josef Maria Bauer.;Mireen Friedrich-Rust.;Stanislas Pol.;Ivica Grgurevic.;Rongqin Zheng.;Sven Francque.;Halima Gottfriedovà.;Sanda Mustapic.;Ioan Sporea.;Annalisa Berzigotti.;Frank Erhard Uschner.;Benedikt Simbrunner.;Maxime Ronot.;Christophe Cassinotto.;Maria Kjaergaard.;Filipe Andrade.;Martin Schulz.;Georg Semmler.;Ida Tjesic Drinkovic.;Johannes Chang.;Maximilian Joseph Brol.;Pierre Emmanuel Rautou.;Thomas Vanwolleghem.;Christian P Strassburg.;Jerome Boursier.;Philip Georg Ferstl.;Ditlev Nytoft Rasmussen.;Thomas Reiberger.;Valerie Vilgrain.;Aymeric Guibal.;Olivier Guillaud.;Stefan Zeuzem.;Camille Vassord.;Xue Lu.;Luisa Vonghia.;Renata Senkerikova.;Alina Popescu.;Cristina Margini.;Wenping Wang.;Maja Thiele.;Chrisitan Jansen.
来源: Gut. 2022年71卷2期402-414页
Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients.
1236. Artificial intelligence in GI endoscopy: stumbling blocks, gold standards and the role of endoscopy societies.
作者: Rüdiger Schmitz.;Rene Werner.;Alessandro Repici.;Raf Bisschops.;Alexander Meining.;Michael Zornow.;Helmut Messmann.;Cesare Hassan.;Prateek Sharma.;Thomas Rösch.
来源: Gut. 2022年71卷3期451-454页 1237. Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease.
作者: Min-Seok Rha.;Ji Won Han.;June-Young Koh.;Ha Seok Lee.;Jong Hoon Kim.;Kyungjoo Cho.;Soon Il Kim.;Myoung Soo Kim.;Jae Geun Lee.;Su-Hyung Park.;Dong Jin Joo.;Jun Yong Park.;Eui-Cheol Shin.
来源: Gut. 2022年71卷3期605-615页
The liver acts as a frontline barrier against diverse gut-derived pathogens, and the sinusoid is the primary site of liver immune surveillance. However, little is known about liver sinusoidal immune cells in the context of chronic liver disease (CLD). Here, we investigated the antibacterial capacity of liver sinusoidal γδ T cells in patients with various CLDs.
1238. Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
作者: Benjamin Goeppert.;Damian Stichel.;Reka Toth.;Sarah Fritzsche.;Moritz Anton Loeffler.;Anna Melissa Schlitter.;Olaf Neumann.;Yassen Assenov.;Monika Nadja Vogel.;Arianeb Mehrabi.;Katrin Hoffmann.;Bruno Köhler.;Christoph Springfeld.;Dieter Weichenhan.;Christoph Plass.;Irene Esposito.;Peter Schirmacher.;Andreas von Deimling.;Stephanie Roessler.
来源: Gut. 2022年71卷2期391-401页
A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma (CCA) and may pave the way to early diagnosis and better treatment options.
1239. Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn's disease.
作者: Ren Mao.;Genevieve Doyon.;Ilyssa O Gordon.;Jiannan Li.;Sinan Lin.;Jie Wang.;Thi Hong Nga Le.;Michael Elias.;Satya Kurada.;Brian Southern.;Mitchell Olman.;Minhu Chen.;Shuai Zhao.;Dina Dejanovic.;Jyotsna Chandra.;Pranab K Mukherjee.;Gail West.;David R Van Wagoner.;Claudio Fiocchi.;Florian Rieder.
来源: Gut. 2022年71卷1期55-67页
Creeping fat, the wrapping of mesenteric fat around the bowel wall, is a typical feature of Crohn's disease, and is associated with stricture formation and bowel obstruction. How creeping fat forms is unknown, and we interrogated potential mechanisms using novel intestinal tissue and cell interaction systems.
1240. Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial.
作者: Jeroen M Schuitenmaker.;Froukje B van Hoeij.;Marlies P Schijven.;Jan Tack.;José M Conchillo.;Eric J Hazebroek.;André J P M Smout.;Albert J Bredenoord.
来源: Gut. 2022年71卷1期10-15页
There is no evidence-based treatment for persistent dysphagia after laparoscopic fundoplication. The aim of this study was to evaluate the effect of pneumatic dilation on persistent dysphagia after laparoscopic fundoplication.
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