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1181. Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma.
作者: Jin Zhou.;Zhong Wu.;Zhouwei Zhang.;Louisa Goss.;James McFarland.;Ankur Nagaraja.;Yingtian Xie.;Shengqing Gu.;Ke Peng.;Yong Zeng.;Xiaoyang Zhang.;Henry Long.;Hiroshi Nakagawa.;Anil Rustgi.;J Alan Diehl.;Matthew Meyerson.;Kwok-Kin Wong.;Adam Bass.
来源: Gut. 2022年71卷4期665-675页
Oesophageal squamous cell carcinoma (OSCC), like other squamous carcinomas, harbour highly recurrent cell cycle pathway alterations, especially hyperactivation of the CCND1/CDK4/6 axis, raising the potential for use of existing CDK4/6 inhibitors in these cancers. Although CDK4/6 inhibition has shown striking success when combined with endocrine therapy in oestrogen receptor positive breast cancer, CDK4/6 inhibitor palbociclib monotherapy has not revealed evidence of efficacy to date in OSCC clinical studies. Herein, we sought to elucidate the identification of key dependencies in OSCC as a foundation for the selection of targets whose blockade could be combined with CDK4/6 inhibition.
1182. Non-compliance with colonoscopy after a positive faecal immunochemical test doubles the risk of dying from colorectal cancer.
作者: Manuel Zorzi.;Jessica Battagello.;Kevin Selby.;Giulia Capodaglio.;Susanna Baracco.;Silvia Rizzato.;Enrico Chinellato.;Stefano Guzzinati.;Massimo Rugge.
来源: Gut. 2022年71卷3期561-567页
The risk of colorectal cancer (CRC) among subjects with a positive faecal immunochemical test (FIT) who do not undergo a colonoscopy is unknown. We estimated whether non-compliance with colonoscopy after a positive FIT is associated with increased CRC incidence and mortality.
1183. Long-term safety of infants from mothers with chronic hepatitis B treated with tenofovir disoproxil in China.
作者: Calvin Q Pan.;Erhei Dai.;Zhongping Duan.;Guorong Han.;Wenjing Zhao.;Yuming Wang.;Huaihong Zhang.;Baoshen Zhu.;Hongxiu Jiang.;Shuqin Zhang.;Xiaohu Zhang.;Huaibin Zou.;Xiuli Chen.;Yu Chen.
来源: Gut. 2022年71卷4期798-806页
The physical and neuromental development of infants remains uncertain after fetal exposure to tenofovir disoproxil fumarate (TDF) for the prevention of mother-to-child transmission of HBV. We aimed to investigate the safety of TDF therapy during the third trimester of pregnancy.
1184. Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-rationale for targeting ARID1A deficiency.
作者: Xiaochuan Dong.;Shumei Song.;Yuan Li.;Yibo Fan.;Lulu Wang.;Ruiping Wang.;Longfei Huo.;Ailing Scott.;Yan Xu.;Melissa Pool Pizzi.;Lang Ma.;Ying Wang.;Jiangkang Jin.;Wei Zhao.;Xiaodan Yao.;Randy L Johnson.;Linghua Wang.;Zhenning Wang.;Guang Peng.;Jaffer A Ajani.
来源: Gut. 2022年71卷3期467-478页
Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A (ARID1A) and mTOR pathway activation occur frequently in GAC. Targeting the mechanistic target of rapamycin (mTOR) pathway in unselected patients has failed to show survival benefit. A deeper understanding of GAC might identify a subset that can benefit from mTOR inhibition.
1186. Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.
作者: Siew C Ng.;Zhilu Xu.;Joyce Wing Yan Mak.;Keli Yang.;Qin Liu.;Tao Zuo.;Whitney Tang.;Louis Lau.;Rashid N Lui.;Sunny H Wong.;Yee Kit Tse.;Amy Y L Li.;Kitty Cheung.;Jessica Y L Ching.;Vincent W S Wong.;Alice P S Kong.;Ronald C W Ma.;Elaine Y K Chow.;Simon K H Wong.;Ivan Chak Hang Ho.;Paul K S Chan.;Francis K L Chan.
来源: Gut. 2022年71卷4期716-723页
The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).
1188. Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
作者: Nestor Nivardo Jiménez-Vargas.;Yang Yu.;Dane D Jensen.;Diana Daeun Bok.;Matthew Wisdom.;Rocco Latorre.;Cintya Lopez.;Josue O Jaramillo-Polanco.;Claudius Degro.;Mabel Guzman-Rodriguez.;Quentin Tsang.;Zachary Snow.;Brian L Schmidt.;David E Reed.;Alan Edward Lomax.;Kara Gross Margolis.;Christoph Stein.;Nigel W Bunnett.;Stephen J Vanner.
来源: Gut. 2022年71卷4期695-704页
The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), which preferentially activates MOPr in acidified diseased tissues, would inhibit pain in a preclinical model of inflammatory bowel disease (IBD) without side effects in healthy tissues.
1193. Predicting endoscopic remission in Crohn's disease by the modified multiplier SES-CD (MM-SES-CD).
作者: Neeraj Narula.;Emily C L Wong.;Jean-Frederic Colombel.;William J Sandborn.;John Kenneth Marshall.;Marco Daperno.;Walter Reinisch.;Parambir S Dulai.
来源: Gut. 2022年71卷6期1078-1087页
The Simple Endoscopic Score for Crohn's disease (SES-CD) is the primary tool for measurement of mucosal inflammation in clinical trials but lacks prognostic potential. We set to develop and validate a modified multiplier of the SES-CD (MM-SES-CD), which takes into consideration each individual parameter's prognostic value for achieving endoscopic remission (ER) while on active therapy.
1194. Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment.
作者: Ester Pagano.;Joshua E Elias.;Georg Schneditz.;Svetlana Saveljeva.;Lorraine M Holland.;Francesca Borrelli.;Tom H Karlsen.;Arthur Kaser.;Nicole C Kaneider.
来源: Gut. 2022年71卷3期509-520页
Primary sclerosing cholangitis (PSC) is in 70% of cases associated with inflammatory bowel disease. The hypermorphic T108M variant of the orphan G protein-coupled receptor GPR35 increases risk for PSC and ulcerative colitis (UC), conditions strongly predisposing for inflammation-associated liver and colon cancer. Lack of GPR35 reduces tumour numbers in mouse models of spontaneous and colitis associated cancer. The tumour microenvironment substantially determines tumour growth, and tumour-associated macrophages are crucial for neovascularisation. We aim to understand the role of the GPR35 pathway in the tumour microenvironment of spontaneous and colitis-associated colon cancers.
1198. Composition, diversity and potential utility of intervention-naïve pancreatic cancer intratumoral microbiome signature profiling via endoscopic ultrasound.
作者: Ferga C Gleeson.;Patricio Jeraldo.;Michael J Levy.;Stephen J Murphy.;Helena Mendes-Soares.;Giannoula Karagouga.;Alexa F Mccune.;Ana Garcia Garcia Deparedes.;Benjamin R Kipp.;Stephanie D Song.;Sahil Khanna.;Darrell S Pardi.;Nicholas Chia.
来源: Gut. 2022年71卷2期441-443页 1199. Long-term outcomes after endoscopic treatment for Barrett's neoplasia with radiofrequency ablation ± endoscopic resection: results from the national Dutch database in a 10-year period.
作者: Sanne van Munster.;Esther Nieuwenhuis.;Bas L A M Weusten.;Lorenza Alvarez Herrero.;Auke Bogte.;Alaa Alkhalaf.;B E Schenk.;Erik J Schoon.;Wouter Curvers.;Arjun D Koch.;Steffi Elisabeth Maria van de Ven.;Pieter Jan Floris de Jonge.;Tjon J Tang.;Wouter B Nagengast.;Frans T M Peters.;Jessie Westerhof.;Martin H M G Houben.;Jacques Jghm Bergman.;Roos E Pouw.; .
来源: Gut. 2022年71卷2期265-276页
Radiofrequency ablation (RFA)±endoscopic resection (ER) is the preferred treatment for early neoplasia in Barrett's oesophagus (BE). We aimed to report short-term and long-term outcomes for all 1384 patients treated in the Netherlands (NL) from 2008 to 2018, with uniform treatment and follow-up (FU) in a centralised setting.
1200. Gastric per-oral endoscopic myotomy (G-POEM) for refractory gastroparesis: results from an international prospective trial.
作者: Kia Vosoughi.;Yervant Ichkhanian.;Petros Benias.;Larry Miller.;A Aziz Aadam.;Joseph R Triggs.;Ryan Law.;William Hasler.;Nicole Bowers.;Dalton Chaves.;Alberto M Ponte-Neto.;Peter Draganov.;Dennis Yang.;Maan El Halabi.;Omid Sanaei.;Olaya Isabella Brewer Gutierrez.;Robert Stephen Bulat.;John Pandolfino.;Mouen Khashab.
来源: Gut. 2022年71卷1期25-33页
Although gastric per-oral endoscopic myotomy (G-POEM) is considered a promising technique for the management of refractory gastroparesis, high-quality evidence is limited. We prospectively investigated the efficacy and safety of G-POEM in unselected patients with refractory gastroparesis.
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