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104. Relationship of coffee consumption with colonic diverticulosis.
作者: Osman Cagin Buldukoglu.;Serkan Ocal.;Serdar Akca.;Galip Egemen Atar.;Ferda Akbay Harmandar.;Ayhan Hilmi Cekin.
来源: BMC Gastroenterol. 2025年25卷1期548页
Diverticulosis is the most common benign pathology of the colon. Genetics, inflammation, neuromuscular abnormalities, colonic motility and lifestyle including dietary habits play roles in disease pathogenesis. Coffee is one of the most commonly consumed beverages worldwide and exerts antiinflammatory functions in the human body as well as affecting colonic motility and neuromuscular physiology of the gastrointestinal system. Therefore, this study was planned to investigate the relationship between coffee consumption and diverticulosis.
105. Prognostic value of neutrophil-to-lymphocyte ratio in septic patients with liver cirrhosis: a cohort study.
Inflammation plays a critical role in the pathogenesis of both sepsis and cirrhosis. The neutrophil-to-lymphocyte ratio (NLR), a composite inflammatory marker, has garnered increasing attention. However, the association between NLR and the risk of mortality in patients with cirrhosis and sepsis remains unclarified.
106. Preoperative albumin-bilirubin grade combined with sarcopenia predicts long-term outcomes after laparoscopic gastrectomy for advanced gastric cancer.
作者: Shuangshuang Hou.;Yang Yu.;Nanbo Li.;Wenjing Yu.;Zhiyuan Dai.;He Li.;Lianyi Guo.;Jiajun Yin.;Ju Wu.
来源: BMC Gastroenterol. 2025年25卷1期550页
This retrospective study evaluated the predictive value of preoperative albumin–bilirubin (ALBI) grade combined with sarcopenia for the long-term prognosis of patients with advanced gastric cancer (AGC) undergoing laparoscopic radical surgery.
107. Association of alterations in transcriptomics and intestinal immune responses with Bifidobacterium longum BAA2573 in improving dextran sulfate sodium-induced colitis.
作者: Wujuan Hao.;Lan Gu.;Renmin Zhou.;Cuilan Huang.;Xuyang Wang.;Yanshan Liu.;Qiong Lin.
来源: BMC Gastroenterol. 2025年25卷1期551页
Preliminary studies have demonstrated the potential of Bifidobacterium longum (B. longum) BAA2573 in alleviating dextran sulfate sodium (DSS)-induced colitis; however, the underlying mechanisms are still unclear.
108. GastroNet-5M: A Multicenter Dataset for Developing Foundation Models in Gastrointestinal Endoscopy.
作者: Martijn R Jong.;Tim G W Boers.;Kiki N Fockens.;Jelmer B Jukema.;Carolus H J Kusters.;Tim J M Jaspers.;Rixta A H van Eijck van Heslinga.;Floor C Slooter.;Maarten R Struyvenberg.;Raf Bisschops.;Joost A van der Putten.;Peter H N de With.;Fons van der Sommen.;Albert J de Groof.;Jacques J G H M Bergman.; .
来源: Gastroenterology. 2025年
Training deep learning systems in endoscopy generally requires vast datasets of annotated images, which are often scarce and costly to obtain. Foundation models are pretrained on large, diverse datasets and can be applied across a wide range of tasks with minimal additional fine-tuning. For endoscopy, foundation models require datasets of general endoscopic images. Yet, datasets for developing such models remain limited. In this study, we present GastroNet-5M, a dataset comprising 4,820,653 endoscopic images of ∼500,000 procedures.
109. Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Improves Colonic Barrier Function and Mast Cell Activation in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: A Mechanistic Trial.
作者: Jun Gao.;Allen A Lee.;Shabnam Abtahi.;Jerrold R Turner.;Madhusudan Grover.;Alexander Schmidt.;Thomas M Schmidt.;Judy W Nee.;Johanna Iturrino.;Anthony Lembo.;William D Chey.;John W Wiley.;Prashant Singh.
来源: Gastroenterology. 2025年
A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (LFD) is the most efficacious dietary therapy for irritable bowel syndrome (IBS). However, the mechanisms by which fermentable oligosaccharides, disaccharides, monosaccharides, and polyols drive IBS pathophysiology are unclear.
110. Selective urokinase inhibition plus chemotherapy: A novel approach to pancreatic cancer treatment via enhanced anti-tumour immunity and decreased metastasis.
作者: S M Zahid Hosen.;Ashna A Kumar.;Zhihong Xu.;Alpha Raj Mekapogu.;Chamini Perera.;Tony Pang.;Ron Pirola.;Jeremy Wilson.;David Goldstein.;Benjamin J Buckley.;Michael J Kelso.;Marie Ranson.;Minoti Apte.
来源: Gastroenterology. 2025年
Improving outcomes for pancreatic ductal adenocarcinoma (PDAC) is critical, as current therapies offer limited benefits for most patients. The urokinase plasminogen activator (uPA) system is key in PDAC progression, driving invasion and metastasis and mediating interactions between pancreatic stellate cells (PSCs) and cancer cells. We previously developed BB2-30F, a potent uPA-selective inhibitor. This study evaluates the therapeutic potential of BB2-30F alone and with gemcitabine in metastatic pancreatic cancer models. Additionally, we aim to clarify the mechanisms underlying these effects.
111. A randomized trial of Endoscopic Submucosal Dissection vs Transanal Minimally Invasive Surgery in Early Rectal Neoplasms. DSETAMIS-2018 Study.
作者: Diego de Frutos Rosa.;Isabel Alonso Sebastián.;David Barquero Declara.;Jesús Badia Closa.;Óscar Nogales.;Luis Miguel Jiménez Gómez.;José Santiago García.;Fátima Valentín Gómez.;Ana Royuela Vicente.;Arsenio Sánchez Movilla.;Eduardo Albéniz Arbizu.;Alberto Herreros de Tejada Echanojáuregui.; .
来源: Gastroenterology. 2025年
The optimal approach for the local resection of early rectal neoplasms (ERNs) remains debated, with limited data comparing transanal minimally invasive surgery (TAMIS) and endoscopic submucosal dissection (ESD).
112. Effect of plasma adsorption and low-volume plasma exchange on intracranial pressure in acute-on-chronic liver failure: a prospective observational study.
作者: Yuanji Ma.;Ziyan Li.;Yan Xu.;Shaoqun Zhou.;Qi Yang.;Lingyao Du.;Fang Chen.;Lang Bai.;Hong Tang.
来源: BMC Gastroenterol. 2025年25卷1期545页
Patients with liver failure may be accompanied by cerebral edema and elevated intracranial pressure (ICP). The effect of plasma adsorption (PA) and low-volume plasma exchange (PE) on ICP were unclear.
113. Fibrosis status, extrahepatic multimorbidity and all-cause mortality in 53,093 women and 74,377 men with metabolic dysfunction associated steatotic liver disease (MASLD) in UK biobank.
作者: Qi Feng.;Chioma N Izzi-Engbeaya.;Pinelopi Manousou.;Mark Woodward.
来源: BMC Gastroenterol. 2025年25卷1期546页
People with metabolic-dysfunction associated steatotic liver disease (MASLD) had higher risk of extrahepatic multimorbidity, and fibrosis is the strongest prognostic factor for mortality in MASLD. This study aimed to investigate how fibrosis was associated with multimorbidity and their relationships with all-cause mortality.
114. METS-VF as a novel predictor of gallstones in U.S. adults: a cross-sectional analysis (NHANES 2017-2020).
作者: Hui Wang.;Longlong Li.;Yi Yang.;Siyu Tao.;Yuan Li.;Hangyu Li.;Heshan Chen.;Ping Wu.
来源: BMC Gastroenterol. 2025年25卷1期547页
Obesity is a well-established risk factor for gallstone formation, but traditional anthropometric measures (e.g., BMI, waist circumference) inadequately assess metabolically active visceral adiposity. The novel Metabolic Score for Visceral Fat (METS-VF) may better capture obesity-related metabolic dysfunction. We aimed to investigate the association between METS-VF and gallstone prevalence and compare its predictive performance against conventional obesity indices (WC, LAP, VAI) in a U.S. national cohort.
116. Risk factors and clinical characteristics of occult pancreaticobiliary reflux in benign gallbladder diseases.
作者: Yukai Xiang.;Chen Qiu.;Hai Hu.;Jingli Cai.;Gang Zhao.;Anhua Huang.;Anan Xu.;Chuanqi He.;Cheng Zhang.;Yulong Yang.;Zhaoyan Jiang.
来源: BMC Gastroenterol. 2025年25卷1期542页
This study aimed to elucidate the clinical characteristics of occult pancreaticobiliary reflux (OPBR) in benign gallbladder diseases, including gallbladder stone (GS), gallbladder polyp (GP), and gallbladder adenomyomatosis (GA).
117. Concurrent nonalcoholic fatty liver disease may decrease liver fibrosis severity in patients with primary biliary cholangitis.
作者: Wenhui Ren.;Zilong Wang.;Xinyue Liu.;Xin Liu.;Danli Ma.;Qian Jin.;Jian Wang.;Jiajun Feng.;Huiying Rao.;Xiaoxiao Wang.;Rui Huang.
来源: BMC Gastroenterol. 2025年25卷1期541页
The purpose of this study was to evaluate how nonalcoholic fatty liver disease (NAFLD) impacts the progression and prognosis of primary biliary cholangitis (PBC).
118. The relationships between symptom clusters and contributing factors in patients with esophageal cancer: structural equation modelling based on theory of unpleasant symptoms.
作者: Xiuqin Ren.;Aijuan Wang.;Xiaowei Wei.;Ying Yu.;Xiancui Wu.;Suping Qin.
来源: BMC Gastroenterol. 2025年25卷1期544页
The caring behaviors of nurses play a crucial role in improving the quality of care in hospitals. This study aimed to investigate the symptom clusters of patients with esophageal cancer undergoing radiotherapy or chemoradiotherapy, as well as the relationship among symptom clusters, NLR (neutrophil to lymphocyte ratio), ALB (albumin), anxiety, depression, social support, self-care, and self-efficacy through structural equation modeling based on the theory of unpleasant symptoms (TOUS).
119. Association of liver related biomarkers with incident cardiovascular disease and all-cause mortality in the Hispanic community health study/study of Latinos (HCHS/SOL), a population-based cohort study.
作者: Mario Jesus Trejo.;James S Floyd.;Daniele Massera.;Martha Daviglus.;Olga Garcia-Bedoya.;Jianwen Cai.;Gregory A Talavera.;Dorathy E Tamayo-Murillo.;Daniel Labovitz.;Robert Kaplan.
来源: BMC Gastroenterol. 2025年25卷1期543页
Metabolic dysfunction-associated steatotic liver disease (MASLD) increases risk of cardiovascular disease (CVD). Despite the high prevalence of MASLD among Hispanic populations, there is a scarcity of research on the associations between non-invasive markers of liver disease and incident CVD and all-cause mortality. In this study we investigated the association of liver related biomarkers with CVD events and all-cause mortality in a population based Hispanic/Latino cohort.
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