"N Engl J Med"[journal] 检索结果

101. Nivolumab for Resected Stage III or IV Melanoma at 9 Years.

作者: Paolo A Ascierto.;Michele Del Vecchio.;Barbara Merelli.;Helen Gogas.;Ana M Arance.;Stéphane Dalle.;Charles Lance Cowey.;Michael Schenker.;Caroline Gaudy-Marqueste.;Jacopo Pigozzo.;Iván Márquez-Rodas.;Marcus O Butler.;Anna Maria Di Giacomo.;Oleg Gligich.;Luis De La Cruz-Merino.;Petr Arenberger.;Victoria Atkinson.;Paul Nathan.;Andrew Hill.;Michael Millward.;Leslie A Fecher.;Nikhil I Khushalani.;Paola Queirolo.;Raheela Soomro.;Dhanrajsinh Rathod.;Margarita Askelson.;Melanie Pe Benito.;Devanand Joseph.;James Larkin.
来源: N Engl J Med. 2025年

In the CheckMate 238 trial, patients with resected stage IIIB-C or stage IV melanoma who were treated with nivolumab had longer recurrence-free survival than those who received ipilimumab. Data were needed on longer-term survival.

102. Thirty Years of Hydroxyurea for Sickle Cell Anemia - Scientific Progress, Global Health Gaps.

作者: Enrico Costa.;Russell Ware.;Leon Tshilolo.;Lucio Luzzatto.
来源: N Engl J Med. 2025年393卷16期1556-1559页

103. Fetal Personhood and Reproductive Criminalization - Implications for Patients, Clinicians, and Public Health.

作者: Taylor Riley.;Asha Hassan.
来源: N Engl J Med. 2025年393卷16期1559-1561页

104. Involving Palliative Care to Improve Outcomes in Sickle Cell Disease.

作者: Eberechi Nwogu-Onyemkpa.;Griffin Collins.;Mgbechi Erondu.;Erica C Kaye.
来源: N Engl J Med. 2025年393卷16期1553-1556页

105. Living in the Present Tense.

作者: James A Feinstein.
来源: N Engl J Med. 2025年393卷16期1561-1563页

106. Thoracic Ectopia Cordis.

作者: Zeljko Duric.;Hrvoje Gasparovic.
来源: N Engl J Med. 2025年393卷16期e26页

107. Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC.

作者: Pasi A Jänne.;David Planchard.;Kunihiko Kobayashi.;James Chih-Hsin Yang.;Ying Liu.;Natalia Valdiviezo.;Tae Min Kim.;Liyan Jiang.;Hiroshi Kagamu.;Noriko Yanagitani.;Jialei Wang.;Bivas Biswas.;Artem Poltoratskiy.;Yeni Neron.;Carlos Rojas.;Leona Koubkova.;Carles Escriu.;Doreen A Ezeife.;Helen Mann.;Elena Armenteros-Monterroso.;Yuri Rukazenkov.;Chee Khoon Lee.; .
来源: N Engl J Med. 2025年

The primary analysis of this trial showed that first-line treatment with osimertinib plus chemotherapy with a platinum-based agent and pemetrexed led to significantly longer progression-free survival than osimertinib monotherapy among patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC). Results from the planned final analysis of overall survival are needed.

108. Sevabertinib in Advanced HER2-Mutant Non-Small-Cell Lung Cancer.

作者: Xiuning Le.;Tae Min Kim.;Herbert H Loong.;Arsela Prelaj.;Boon Cher Goh.;Lin Li.;Yong Fang.;Shun Lu.;Xiaorong Dong.;Lin Wu.;Yuki Shinno.;Gennaro Daniele.;Tsung-Ying Yang.;Hye Ryun Kim.;Gerrina Ruiter.;Jun Zhao.;Silvia Novello.;Liyun Miao.;Pasi A Jänne.;Koichi Goto.;Dominik Rüttinger.;Tine Descamps.;Jan Christoph Brase.;Weichao Bao.;Rui Li.;Nicoletta Brega.;Paolo Grassi.;Nicolas Girard.;Daniel Shao-Weng Tan.; .
来源: N Engl J Med. 2025年393卷18期1819-1832页

HER2 gene mutations occur in 2 to 4% of patients with non-small-cell lung cancer (NSCLC). Sevabertinib is an oral, reversible tyrosine kinase inhibitor that has shown anti-HER2 activity in preclinical models.

109. Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today.

作者: Lisa Rosenbaum.
来源: N Engl J Med. 2025年393卷15期1537-1541页

110. More about the Phase 2a Study of Baxdrostat in Primary Aldosteronism. Reply.

作者: Adina F Turcu.;Mason W Freeman.;Morris J Brown.
来源: N Engl J Med. 2025年393卷15期1550-1552页

111. More about the Phase 2a Study of Baxdrostat in Primary Aldosteronism.

作者: Tobias Carling.;Ute I Scholl.
来源: N Engl J Med. 2025年393卷15期1550页

112. Competency-Based Medical Education at the Front Lines of Patient Care. Reply.

作者: Dawn Cooper.;Eric S Holmboe.
来源: N Engl J Med. 2025年393卷15期1549-1550页

113. Competency-Based Medical Education at the Front Lines of Patient Care.

作者: Kévin Yauy.;Camille Roubille.
来源: N Engl J Med. 2025年393卷15期1548-1549页

114. Competency-Based Medical Education at the Front Lines of Patient Care.

作者: George W Meyer.
来源: N Engl J Med. 2025年393卷15期1548页

115. Competency-Based Medical Education at the Front Lines of Patient Care.

作者: Alexander A Iyer.;Nicole M Dubosh.;Richard M Schwartzstein.
来源: N Engl J Med. 2025年393卷15期1548页

116. BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease.

作者: Laura Bucci.;Sebastian Böltz.;Melanie Hagen.;Carlo Tur.;Danae-Mona Nöthling.;Tobias Rothe.;Andreas Wirsching.;Janina Auth.;Jochen Wacker.;Markus Eckstein.;Stefano Alivernini.;Aline Bozec.;Christina Bergmann.;Maria-Antonietta D'Agostino.;Luis Munoz.;Jürgen Rech.;Lars Kihm.;Maria Gabriella Raimondo.;Georg Schett.;Ricardo Grieshaber-Bouyer.
来源: N Engl J Med. 2025年393卷15期1544-1547页

117. Sentinel Lymphadenectomy for Early-Stage Cervical Cancer - the New Standard?

作者: Kristin Bixel.
来源: N Engl J Med. 2025年393卷15期1534-1536页

118. Case 29-2025: A 43-Year-Old Woman with Depression, Suicidal Ideation, and Fever.

作者: Michael S Abers.;Robert J Lawson.;Sandra B Nelson.;Melanie C Kwan.
来源: N Engl J Med. 2025年393卷15期1522-1531页

119. Stercoral Colitis.

作者: Aleksandra Bajer.;Erica Levine.
来源: N Engl J Med. 2025年393卷15期e23页

120. Hair Loss in Women.

作者: Elise A Olsen.
来源: N Engl J Med. 2025年393卷15期1509-1520页

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