当前位置: 首页 >> 检索结果
1162. International consensus to standardise histopathological scoring for small bowel strictures in Crohn's disease.
作者: Ilyssa O Gordon.;Dominik Bettenworth.;Arne Bokemeyer.;Amitabh Srivastava.;Christophe Rosty.;Gert de Hertogh.;Marie E Robert.;Mark A Valasek.;Ren Mao.;Jiannan Li.;Noam Harpaz.;Paula Borralho.;Reetesh K Pai.;Robert Odze.;Roger Feakins.;Claire E Parker.;Leonardo Guizzetti.;Tran Nguyen.;Lisa M Shackelton.;William J Sandborn.;Vipul Jairath.;Mark Baker.;David Bruining.;Joel G Fletcher.;Brian G Feagan.;Rish K Pai.;Florian Rieder.; .
来源: Gut. 2022年71卷3期479-486页
Effective medical therapy and validated trial outcomes are lacking for small bowel Crohn's disease (CD) strictures. Histopathology of surgically resected specimens is the gold standard for correlation with imaging techniques. However, no validated histopathological scoring systems are currently available for small bowel stricturing disease. We convened an expert panel to evaluate the appropriateness of histopathology scoring systems and items generated based on panel opinion.
1164. Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men.
作者: Jun Li.;Yanping Li.;Kerry L Ivey.;Dong D Wang.;Jeremy E Wilkinson.;Adrian Franke.;Kyu Ha Lee.;Andrew Chan.;Curtis Huttenhower.;Frank B Hu.;Eric B Rimm.;Qi Sun.
来源: Gut. 2022年71卷4期724-733页
Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link between red meat intake and poor cardiometabolic health. We investigated whether gut microbiome could modify associations of dietary precursors with TMAO concentrations and cardiometabolic risk markers among free-living individuals.
1165. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
作者: Sarra Smati.;Arnaud Polizzi.;Anne Fougerat.;Sandrine Ellero-Simatos.;Yuna Blum.;Yannick Lippi.;Marion Régnier.;Alexia Laroyenne.;Marine Huillet.;Muhammad Arif.;Cheng Zhang.;Frederic Lasserre.;Alain Marrot.;Talal Al Saati.;JingHong Wan.;Caroline Sommer.;Claire Naylies.;Aurelie Batut.;Celine Lukowicz.;Tiffany Fougeray.;Blandine Tramunt.;Patricia Dubot.;Lorraine Smith.;Justine Bertrand-Michel.;Nathalie Hennuyer.;Jean-Philippe Pradere.;Bart Staels.;Remy Burcelin.;Françoise Lenfant.;Jean-François Arnal.;Thierry Levade.;Laurence Gamet-Payrastre.;Sandrine Lagarrigue.;Nicolas Loiseau.;Sophie Lotersztajn.;Catherine Postic.;Walter Wahli.;Christophe Bureau.;Maeva Guillaume.;Adil Mardinoglu.;Alexandra Montagner.;Pierre Gourdy.;Hervé Guillou.
来源: Gut. 2022年71卷4期807-821页
We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty liver disease (NAFLD). We investigated diet-induced phenotypic responses to define sex-specific regulation between healthy liver and NAFLD to identify influential pathways in different preclinical murine models and their relevance in humans.
1166. Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease.
作者: Nobuharu Tamaki.;Nagambika Munaganuru.;Jinho Jung.;Aed Qas Yonan.;Rohan R Loomba.;Richele Bettencourt.;Veeral Ajmera.;Mark A Valasek.;Cynthia Behling.;Claude B Sirlin.;Rohit Loomba.
来源: Gut. 2022年71卷5期983-990页
Emerging data suggest that a 30% relative decline in liver fat, as assessed by MRI-proton density fat fraction (MRI-PDFF), may be associated with Non-Alcoholic Fatty Liver Disease Activity Score improvement, but the association between decline in MRI-PDFF and fibrosis regression is not known. Therefore, we aimed to examine the association between ≥30% relative decline in MRI-PDFF and fibrosis regression in non-alcoholic fatty liver disease (NAFLD).
1168. Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size.
作者: Wenzel M Hackeng.;Lodewijk A A Brosens.;Joo Young Kim.;Roderick O'Sullivan.;You-Na Sung.;Ta-Chiang Liu.;Dengfeng Cao.;Michelle Heayn.;Jacqueline Brosnan-Cashman.;Soyeon An.;Folkert H M Morsink.;Charlotte M Heidsma.;Gerlof D Valk.;Menno R Vriens.;Els Nieveen van Dijkum.;G Johan A Offerhaus.;Koen M A Dreijerink.;Herbert Zeh.;Amer H Zureikat.;Melissa Hogg.;Kenneth Lee.;David Geller.;J Wallis Marsh.;Alessandro Paniccia.;Melanie Ongchin.;James F Pingpank.;Nathan Bahary.;Muaz Aijazi.;Randall Brand.;Jennifer Chennat.;Rohit Das.;Kenneth E Fasanella.;Asif Khalid.;Kevin McGrath.;Savreet Sarkaria.;Harkirat Singh.;Adam Slivka.;Michael Nalesnik.;Xiaoli Han.;Marina N Nikiforova.;Rita Teresa Lawlor.;Andrea Mafficini.;Boris Rusev.;Vincenzo Corbo.;Claudio Luchini.;Samantha Bersani.;Antonio Pea.;Sara Cingarlini.;Luca Landoni.;Roberto Salvia.;Massimo Milione.;Michele Milella.;Aldo Scarpa.;Seung-Mo Hong.;Christopher M Heaphy.;Aatur D Singhi.
来源: Gut. 2022年71卷5期961-973页
Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic biomarkers for non-functional pancreatic neuroendocrine tumours (NF-PanNETs). However, they have not been comprehensively evaluated, especially among small NF-PanNETs (≤2.0 cm). Moreover, their status in neuroendocrine tumours (NETs) from other sites remains unknown.
1169. Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial.
作者: Rakesh Kalapala.;Arun Karyampudi.;Zaheer Nabi.;Santosh Darisetty.;Nitin Jagtap.;Mohan Ramchandani.;Rajesh Gupta.;Sundeep Lakhtakia.;Rajesh Goud.;G Venkat Rao.;Prateek Sharma.;D Nageshwar Reddy.
来源: Gut. 2022年71卷4期686-694页
The majority of endoscopic antireflux procedures for GERD are cumbersome to use and randomised long-term data are sparse. We conducted such a trial to determine the efficacy and safety of a novel, easy to use endoscopic full-thickness fundoplication (EFTP) device in patients with GERD.
1171. A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.
作者: Bernhard Kloesch.;Vivien Ionasz.;Sumit Paliwal.;Natascha Hruschka.;Jaime Martinez de Villarreal.;Rupert Öllinger.;Sebastian Mueller.;Hans Peter Dienes.;Martin Schindl.;Elisabeth S Gruber.;Judith Stift.;Dietmar Herndler-Brandstetter.;Gwen A Lomberk.;Barbara Seidler.;Dieter Saur.;Roland Rad.;Raul A Urrutia.;Francisco X Real.;Paola Martinelli.
来源: Gut. 2022年71卷4期766-777页
Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal adenocarcinoma (PDAC) exist, which consistently identified a subtype of highly aggressive PDACs with basal-like features, including ΔNp63 expression and loss of the epithelial master regulator GATA6. We investigated the precise molecular events driving PDAC progression and the emergence of the basal programme.
1174. HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4.
作者: Long V Pham.;Martin Schou Pedersen.;Ulrik Fahnøe.;Carlota Fernandez-Antunez.;Daryl Humes.;Kristian Schønning.;Santseharay Ramirez.;Jens Bukh.
来源: Gut. 2022年71卷3期627-642页
HCV-genotype 4 infections are a major cause of liver diseases in the Middle East/Africa with certain subtypes associated with increased risk of direct-acting antiviral (DAA) treatment failures. We aimed at developing infectious genotype 4 cell culture systems to understand the evolutionary genetic landscapes of antiviral resistance, which can help preserve the future efficacy of DAA-based therapy.
1175. Six-month follow-up of gut microbiota richness in patients with COVID-19.
作者: Yanfei Chen.;Silan Gu.;Yunbo Chen.;Haifeng Lu.;Ding Shi.;Jing Guo.;Wen-Rui Wu.;Ya Yang.;Yongtao Li.;Kai-Jin Xu.;Cheng Ding.;Rui Luo.;Chenjie Huang.;Ling Yu.;Min Xu.;Ping Yi.;Jun Liu.;Jing-Jing Tao.;Hua Zhang.;Longxian Lv.;Baohong Wang.;Jifang Sheng.;Lanjuan Li.
来源: Gut. 2022年71卷1期222-225页 1176. Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment.
作者: Zhibo Xie.;Ya Gao.;Chiakang Ho.;Lequn Li.;Chen Jin.;Xiaoyi Wang.;Caifeng Zou.;Yishen Mao.;Xiaobo Wang.;Qingfeng Li.;Deliang Fu.;Yi-Fan Zhang.
来源: Gut. 2022年71卷3期568-579页
Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial for pre-metastatic microenvironment formation and metastasis. This study aimed to explore the underlying mechanisms of how PDAC-derived exosomes (Pex) modulate the liver microenvironment and promote metastasis.
1178. Long-term yield of pancreatic cancer surveillance in high-risk individuals.
作者: Kasper A Overbeek.;Iris J M Levink.;Brechtje D M Koopmann.;Femme Harinck.;Ingrid C A W Konings.;Margreet G E M Ausems.;Anja Wagner.;Paul Fockens.;Casper H van Eijck.;Bas Groot Koerkamp.;Olivier R C Busch.;Marc G Besselink.;Barbara A J Bastiaansen.;Lydi M J W van Driel.;Nicole S Erler.;Frank P Vleggaar.;Jan-Werner Poley.;Djuna L Cahen.;Jeanin E van Hooft.;Marco J Bruno.; .
来源: Gut. 2022年71卷6期1152-1160页
We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.
|