1146. Attention Among Health Care Professionals : A Scoping Review.
作者: Mark J Kissler.;Samuel Porter.;Michelle Knees.;Katherine Kissler.;Angela Keniston.;Marisha Burden.
来源: Ann Intern Med. 2024年177卷7期941-952页
The concept of attention can provide insight into the needs of clinicians and how health systems design can impact patient care quality and medical errors.
1147. Trends in Diet Quality Among U.S. Adults From 1999 to 2020 by Race, Ethnicity, and Socioeconomic Disadvantage.
Few data have assessed trends in diet quality among U.S. adults.
1149. Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data.
作者: Yu-Han Chiu.;Krista F Huybrechts.;Elisabetta Patorno.;Jennifer J Yland.;Carolyn E Cesta.;Brian T Bateman.;Ellen W Seely.;Miguel A Hernán.;Sonia Hernández-Díaz.
来源: Ann Intern Med. 2024年177卷7期862-870页
Metformin is a first-line pharmacotherapy for type 2 diabetes, but there is limited evidence about its safety in early pregnancy.
1153. Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns.
作者: Ran S Rotem.;Marc G Weisskopf.;Krista F Huybrechts.;Sonia Hernández-Díaz.
来源: Ann Intern Med. 2024年177卷7期851-861页
Metformin is the most used oral antidiabetic medication. Despite its established safety profile, it has known antiandrogenic and epigenetic modifying effects. This raised concerns about possible adverse developmental effects caused by genomic alterations related to paternal use of metformin during the spermatogenesis period preceding conception.
1154. COVID-19 Vaccine Side Effects and Long-Term Neutralizing Antibody Response : A Prospective Cohort Study.
作者: Ethan G Dutcher.;Elissa S Epel.;Ashley E Mason.;Frederick M Hecht.;James E Robinson.;Stacy S Drury.;Aric A Prather.
来源: Ann Intern Med. 2024年177卷7期892-900页
Concern about side effects is a common reason for SARS-CoV-2 vaccine hesitancy.
1155. Type 2 Diabetes.
Type 2 diabetes (T2D) is a prevalent disease that increases risk for vascular, renal, and neurologic complications. Prevention and treatment of T2D and its complications are paramount. Many advancements in T2D care have emerged over the past 5 years, including increased understanding of the importance of early intensive glycemic control, mental health, social determinants of health, healthy eating patterns, continuous glucose monitoring, and the benefits of some drugs for preventing cardiorenal disease. This review summarizes the evidence supporting T2D prevention and treatment, focusing on aspects that are commonly in the purview of primary care physicians.
1157. The Effect of Heat Exposure on Myocardial Blood Flow and Cardiovascular Function.
作者: Hadiatou Barry.;Josep Iglesies-Grau.;Georgia K Chaseling.;Jade Paul.;Camila Gosselin.;Caroline D'Oliviera-Sousa.;Martin Juneau.;Francois Harel.;David Kaiser.;Matthieu Pelletier-Galarneau.;Daniel Gagnon.
来源: Ann Intern Med. 2024年177卷7期901-910页
Heat extremes are associated with greater risk for cardiovascular death. The pathophysiologic mechanisms mediating this association are unknown.
1158. How Would You Manage This Patient With Type 2 Diabetes and Chronic Kidney Disease? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
作者: Gerald W Smetana.;Giulio R Romeo.;Sylvia E Rosas.;Risa B Burns.
来源: Ann Intern Med. 2024年177卷6期800-811页
Nearly 15% of U.S. adults have diabetes; type 2 diabetes (T2D) accounts for more than 90% of cases. Approximately one third of all patients with diabetes will develop chronic kidney disease (CKD). All patients with T2D should be screened annually for CKD with both a urine albumin-creatinine ratio and an estimated glomerular filtration rate. Research into strategies to slow the worsening of CKD and reduce renal and cardiovascular morbidity in patients with T2D and CKD has evolved substantially. In 2022, a consensus statement from the American Diabetes Association and the Kidney Disease: Improving Global Outcomes recommended prioritizing the use of sodium-glucose cotransporter-2 inhibitors and metformin and included guidance for add-on therapy with glucagon-like peptide 1 receptors agonists for most patients whose first-line therapy failed. It also recommended nonsteroidal mineralocorticoid receptor antagonists for patients with hypertension that is not adequately controlled with angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Here, an endocrinologist and a nephrologist discuss the care of patients with T2D and CKD and how they would apply the consensus statement to the care of an individual patient with T2D who is unaware that he has CKD.
|