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1001. CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.
作者: Jonas Nørskov Søndergaard.;Christian Sommerauer.;Ionut Atanasoai.;Laura C Hinte.;Keyi Geng.;Giulia Guiducci.;Lars Bräutigam.;Myriam Aouadi.;Lovorka Stojic.;Isabel Barragan.;Claudia Kutter.
来源: Gut. 2022年71卷10期2081-92页
To better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs).
1002. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis.
作者: Gaia Bellomo.;Carolyn Rainer.;Valeria Quaranta.;Yuliana Astuti.;Meirion Raymant.;Elzbieta Boyd.;Ruth Stafferton.;Fiona Campbell.;Paula Ghaneh.;Christopher M Halloran.;Dean E Hammond.;Jennifer P Morton.;Daniel Palmer.;Dale Vimalachandran.;Robert Jones.;Ainhoa Mielgo.;Michael C Schmid.
来源: Gut. 2022年71卷11期2284-2299页
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood.
1003. Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis.
作者: Alexander C Ford.;Evangelos Tsipotis.;Yuhong Yuan.;Grigorios I Leontiadis.;Paul Moayyedi.
来源: Gut. 2022年
Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs) published since. We evaluated impact of eradication therapy on both cure and improvement of FD, as well as whether any benefit was likely to arise from eradication of H. pylori.
1004. Establishment of a validated central reading system for ileocolonoscopy in an academic setting.
作者: Tim Raine.;Holly Pavey.;Wendi Qian.;Gordon W Moran.;Sreedhar Subramanian.;Lizzie Swaby.;Simon Pl Travis.;Shahida Din.;Peter M Irving.;James O Lindsay.;Miles Parkes.;Nicholas A Kennedy.
来源: Gut. 2022年71卷4期661-664页 1006. Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health.
作者: Menglei Shuai.;Yuanqing Fu.;Hai-Li Zhong.;Wanglong Gou.;Zengliang Jiang.;Yuhui Liang.;Zelei Miao.;Jin-Jian Xu.;Tien Huynh.;Mark L Wahlqvist.;Yu-Ming Chen.;Ju-Sheng Zheng.
来源: Gut. 2022年71卷9期1812-1820页
The human gut fungal community, known as the mycobiome, plays a fundamental role in the gut ecosystem and health. Here we aimed to investigate the determinants and long-term stability of gut mycobiome among middle-aged and elderly adults. We further explored the interplay between gut fungi and bacteria on metabolic health.
1007. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
作者: Chun Chen.;Jianming Liao.;Yiyuan Xia.;Xia Liu.;Rheinallt Jones.;John Haran.;Beth McCormick.;Timothy Robert Sampson.;Ashfaqul Alam.;Keqiang Ye.
来源: Gut. 2022年71卷11期2233-2252页
This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer's disease (AD) pathogenesis.
1008. Risk of acute arterial events associated with treatment of inflammatory bowel diseases: a nationwide Danish cohort study.
作者: Daniel Ward.;Mikael Andersson.;Nynne Nyboe Andersen.;Kristine Højgaard Allin.;Laurent Beaugerie.;Tine Jess.;Julien Kirchgesner.
来源: Gut. 2022年71卷11期2373-2374页 1009. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
作者: Eugeni Belda.;Lise Voland.;Valentina Tremaroli.;Gwen Falony.;Solia Adriouch.;Karen E Assmann.;Edi Prifti.;Judith Aron-Wisnewsky.;Jean Debédat.;Tiphaine Le Roy.;Trine Nielsen.;Chloé Amouyal.;Sébastien André.;Fabrizio Andreelli.;Matthias Blüher.;Rima Chakaroun.;Julien Chilloux.;Luis Pedro Coelho.;Maria Carlota Dao.;Promi Das.;Soraya Fellahi.;Sofia Forslund.;Nathalie Galleron.;Tue H Hansen.;Bridget Holmes.;Boyang Ji.;Helle Krogh Pedersen.;Phuong Le.;Emmanuelle Le Chatelier.;Christian Lewinter.;Louise Mannerås-Holm.;Florian Marquet.;Antonis Myridakis.;Veronique Pelloux.;Nicolas Pons.;Benoit Quinquis.;Christine Rouault.;Hugo Roume.;Joe-Elie Salem.;Nataliya Sokolovska.;Nadja B Søndertoft.;Sothea Touch.;Sara Vieira-Silva.; .;Pilar Galan.;Jens Holst.;Jens Peter Gøtze.;Lars Køber.;Henrik Vestergaard.;Torben Hansen.;Serge Hercberg.;Jean-Michel Oppert.;Jens Nielsen.;Ivica Letunic.;Marc-Emmanuel Dumas.;Michael Stumvoll.;Oluf Borbye Pedersen.;Peer Bork.;Stanislav Dusko Ehrlich.;Jean-Daniel Zucker.;Fredrik Bäckhed.;Jeroen Raes.;Karine Clément.
来源: Gut. 2022年71卷12期2463-2480页
Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome's functional composition in healthy metabolic state and the most severe states of obesity and type 2 diabetes within the MetaCardis cohort. We focused on the role of B vitamins and B7/B8 biotin for regulation of host metabolic state, as these vitamins influence both microbial function and host metabolism and inflammation.
1010. Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.
作者: Carolina F Ruivo.;Nuno Bastos.;Barbara Adem.;Ines Batista.;Cecilia Duraes.;Carlos A Melo.;Stephanie A Castaldo.;Francisco Campos-Laborie.;Pedro Moutinho-Ribeiro.;Barbara Morão.;Ana Costa-Pinto.;Soraia Silva.;Hugo Osorio.;Sergio Ciordia.;Jose Luis Costa.;David Goodrich.;Bruno Cavadas.;Luisa Pereira.;Tony Kouzarides.;Guilherme Macedo.;Rui Maio.;Fatima Carneiro.;Marília Cravo.;Raghu Kalluri.;Jose Carlos Machado.;Sonia A Melo.
来源: Gut. 2022年71卷10期2043-68页
Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.
1011. Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression.
作者: Fubo Ji.;Jianjuan Zhang.;Niya Liu.;Yuanzhuo Gu.;Yan Zhang.;Peipei Huang.;Nachuan Zhang.;Shengda Lin.;Ran Pan.;Zhuoxian Meng.;Xin-Hua Feng.;Stephanie Roessler.;Xin Zheng.;Junfang Ji.
来源: Gut. 2022年71卷11期2313-2324页
The incidence of hepatocellular carcinoma (HCC) shows an obvious male dominance in rodents and humans. We aimed to identify the key autosomal liver-specific sex-related genes and investigate their roles in hepatocarcinogenesis.
1013. Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner.
作者: Yuan-Chen Wang.;Xiao-Tong Mao.;Dong Yu.;Sheng-Han Mao.;Zhao-Shen Li.;Wen-Bin Zou.;Zhuan Liao.
来源: Gut. 2022年71卷11期2369-2371页 1014. Reprogramming the spleen into a functioning 'liver' in vivo.
作者: Chunyan Liu.;Lintao Wang.;Mengzhen Xu.;Yajie Sun.;Zhen Xing.;Junfeng Zhang.;Chunming Wang.;Lei Dong.
来源: Gut. 2022年71卷11期2325-2336页
Liver regeneration remains one of the biggest clinical challenges. Here, we aim to transform the spleen into a liver-like organ via directly reprogramming the splenic fibroblasts into hepatocytes in vivo.
1015. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.
作者: Meritxell Ventura-Cots.;Josepmaria Argemi.;Patricia D Jones.;Carolin Lackner.;Mohamed El Hag.;Juan G Abraldes.;Edilmar Alvarado.;Ana Clemente.;Samhita Ravi.;Antonio Alves.;Mohamed Alboraie.;Jose Altamirano.;Sergio Barace.;Francisco Bosques.;Robert Brown.;Juan Caballeria.;Joaquin Cabezas.;Sofia Carvalhana.;Helena Cortez-Pinto.;Adilia Costa.;Delphine Degré.;Carlos Fernandez-Carrillo.;Nathalie Ganne-Carrie.;Guadalupe Garcia-Tsao.;Joan Genesca.;John Koskinas.;Nicolas Lanthier.;Alexandre Louvet.;Juan José Lozano.;Michael R Lucey.;Steven Masson.;Philippe Mathurin.;Nahum Mendez-Sanchez.;Rosa Miquel.;Christophe Moreno.;Taofic Mounajjed.;Gemma Odena.;Won Kim.;Pau Sancho-Bru.;R Warren Sands.;Justyna Szafranska.;Laurine Verset.;Bern Schnabl.;Christine Sempoux.;Vijay Shah.;Debbie Lindsay Shawcross.;Rudolf E Stauber.;Beate K Straub.;Elizabeth Verna.;Dina Tiniakos.;Eric Trépo.;Victor Vargas.;Càndid Villanueva.;John T Woosley.;Marianne Ziol.;Sebastian Mueller.;Peter Stärkel.;Ramon Bataller.
来源: Gut. 2022年71卷9期1856-1866页
Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking.
1017. Humoral response to SARS-CoV-2 infection among liver transplant recipients.
作者: Chiara Becchetti.;Annelotte G C Broekhoven.;Géraldine Dahlqvist.;Montserrat Fraga.;Marco Fabrizio Zambelli.;Olga Ciccarelli.;Anne-Catherine Saouli.;Arianna Trizzino.;Vanessa Banz.;Jean-François Dufour.;Anna H E Roukens.;Shessy P Torres Morales.;Sebenzile K Myeni.;Marjolein Kikkert.;Mariet C W Feltkamp.;Minneke J Coenraad.
来源: Gut. 2022年71卷4期746-756页
Immunosuppressive agents are known to interfere with T and/or B lymphocytes, which are required to mount an adequate serologic response. Therefore, we aim to investigate the antibody response to SARS-CoV-2 in liver transplant (LT) recipients after COVID-19.
1018. Modulation of gut microbiota impacts diet-induced and drug-induced alopecia in mice.
作者: Siu Lam.;Jingwan Zhang.;Keli Yang.;Lok Cheung Chu.;Wenyi Zhu.;Whitney Tang.;Francis K L Chan.;Paul K S Chan.;William K K Wu.;Siew C Ng.
来源: Gut. 2022年71卷11期2366-2369页 1019. Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database.
作者: Alessandro Vitale.;Gianluca Svegliati-Baroni.;Alessio Ortolani.;Monica Cucco.;Giulio V Dalla Riva.;Edoardo G Giannini.;Fabio Piscaglia.;Gianludovico Rapaccini.;Mariella Di Marco.;Eugenio Caturelli.;Marco Zoli.;Rodolfo Sacco.;Giuseppe Cabibbo.;Fabio Marra.;Andrea Mega.;Filomena Morisco.;Antonio Gasbarrini.;Francesco Giuseppe Foschi.;Gabriele Missale.;Alberto Masotto.;Gerardo Nardone.;Giovanni Raimondo.;Francesco Azzaroli.;Gianpaolo Vidili.;Filippo Oliveri.;Filippo Pelizzaro.;Rafael Ramirez Morales.;Umberto Cillo.;Franco Trevisani.;Luca Miele.;Giulio Marchesini.;Fabio Farinati.; .
来源: Gut. 2023年72卷1期141-152页
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort.
1020. Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling.
作者: Chen-Ting Hung.;Tung-Hung Su.;Yen-Ting Chen.;Yueh-Feng Wu.;You-Tzung Chen.;Sung-Jan Lin.;Shuei-Liong Lin.;Kai-Chien Yang.
来源: Gut. 2022年71卷9期1876-1891页
Liver fibrosis (LF) occurs following chronic liver injuries. Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain containing 5 (TXNDC5), an ER protein disulfide isomerase (PDI), as a critical mediator of cardiac and lung fibrosis. We aimed to determine if TXNDC5 also contributes to LF and its potential as a therapeutic target for LF.
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