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41. Safety and Effectiveness of Intracoronary Imaging-Guided PCI in Contemporary Practice: Insights From BMC2.
作者: Thomas Basala.;Milan Seth.;Ryan D Madder.;Brett Wanamaker.;Brittany Fuller.;Evan Shlofmitz.;Edouard Daher.;Michael Tucciarone.;Chadi Alraies.;Amir Kaki.;Sunil V Rao.;Hitinder S Gurm.;Devraj Sukul.
来源: Circ Cardiovasc Interv. 2025年e014886页
Studies suggest percutaneous coronary intervention (PCI) guided by intracoronary imaging (ICI) results in larger balloon/stent diameters and longer stents. Whether this occurs in real-world PCI is poorly understood.
42. Response by Demir et al to Letter Regarding Article, "Pressure Derived Indices in the Left Main Coronary Artery: Insights From Comprehensive In Vivo Hemodynamic Studies of Diseased and Unobstructed Vessels".43. American Heart Association National Integrated ASCVD Initiative: An Implementation Initiative to Improve Lipid Management Among Patients With ASCVD.
作者: Chiadi E Ndumele.;Ankeet S Bhatt.;Lynne T Braun.;Steven Chen.;Seth S Martin.;Michael T Mullen.;Nishant P Shah.;Stephen L Sigal.;Tracy Yu-Ping Wang.;Rebecca Alicki.;Chandler Beon.;Haoyun Hong.;Sara O'Kane.;Katherine J Overton.;Kathie Thomas.;Howard Haft.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011627页 44. Cost-Effectiveness of Hypertension Treatment According to 2017 American College of Cardiology and American Heart Association Guidelines.
作者: Joanne M Penko.;Brandon K Bellows.;Susan Hennessy.;Dhruv S Kazi.;Ross Boylan.;Yiyi Zhang.;Pamela G Coxson.;Lee Goldman.;Kirsten Bibbins-Domingo.;Andrew E Moran.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011872页
Compared with the 2003 Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) guideline, the 2017 American College of Cardiology and American Heart Association guideline (ACC/AHA 2017) expanded hypertension diagnostic criteria to blood pressure (BP) ≥130/80 mm Hg and intensified treatment goals to <130/80 mm Hg. The cost-effectiveness of ACC/AHA 2017 guideline treatment has not been quantified.
47. Letter by Kornelius Regarding Article, "Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial".48. Reformulation of the Necroptosis Pathway in Reperfused Myocardial Infarction.
作者: Dongze Qin.;Radheshyam Modanwal.;Madeeha Ghazi.;J Jose Corbalan.;Xiaotong F Jia.;Joshua L Axelrod.;Roneldine Mesidor.;Hee Jae Jang.;Claudio Humeres.;Anis Hanna.;Fahimeh Varzideh.;Michelle D Tallquist.;Gaetano Santulli.;Qinghang Liu.;Lorrie A Kirshenbaum.;Hongmin Ni.;Timothy J Kamp.;Rebekah L Gundry.;Siddharth Balachandran.;Alexei Degterev.;John W Calvert.;Richard N Kitsis.
来源: Circulation. 2025年152卷7期486-488页 49. Response by Docherty et al to Letter Regarding Article, "Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial".
作者: Kieran F Docherty.;Alasdair D Henderson.;Pardeep S Jhund.;Scott D Solomon.;John J V McMurray.
来源: Circulation. 2025年152卷7期e65-e66页 51. An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.
作者: Junhao Xiong.;Shasha Zhang.;Zilong Geng.;Juntao Lin.;Kang Cheng.;Huan Hu.;Yuze Wang.;Xing Liu.;Yuanzhe Sheng.;Ping Yang.;Yige Li.;Shuo Wu.;Xiao Cheng.;Yelan Li.;Aijun Sun.;Alex F Chen.;Daowen Wang.;Chen Chen.;Yan Zhang.;Gengze Wu.;Chunyu Zeng.;Xiaoling Guo.;Xumin Hou.;Ruogu Li.;Yuliang Feng.;Dan Zhu.;Kun Sun.;Bing Zhang.
来源: Circulation. 2025年
Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV resurgence in heart failure (HF), a leading cause of global morbidity and mortality, remain unexplored.
53. Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis.
作者: Daniele Giacoppo.;Hector Alvarez-Covarrubias.;Erion Xhepa.;Yuji Matsuda.;Stefano Cangemi.;Jonathan M Michel.;Anna Sannino.;Johannes Ziegelmüller.;Enrico Criscione.;Motoki Fukutomi.;Manuel Hein.;Romain Didier.;David Meier.;Taishi Okuno.;Sebastian Ludwig.;Marco Ancona.;Dimitry Schewel.;Tommaso Fabris.;Flavien Vincent.;Lisa Voigtlaender.;Francesca Ziviello.;Richard Tanner.;Claudia Tamburino.;Hendrik Ruge.;Mattia Lunardi.;Pablo Codner.;Marco Barbanti.;Fabian Nietlispach.;Holger Nef.;Ivan Casserly.;Vasilis Babaliaros.;Tchetche Didier.;Rudiger Lange.;Martine Gilard.;Matteo Montorfano.;Martin Landt.;Paul Grayburn.;Philipp Ruile.;Nicolas M Van Mieghem.;Francesco Bedogni.;George Dangas.;Corrado Tamburino.;Niklas Schofer.;Francesco Burzotta.;Eric Van Belle.;Franz-Josef Neumann.;Ran Kornowski.;Flavio Ribichini.;Darren Mylotte.;Stephan Windecker.;Gert Richardt.;Lars Sondergaard.;John G Webb.;Giuseppe Tarantini.;Thomas Pilgrim.;Roxana Mehran.;Davide Capodanno.;Adnan Kastrati.;Michael Joner.;Mark S Spence.;Albert M Kasel.;Robert A Byrne.
来源: Circulation. 2025年
Differences between balloon- and self-expandable transcatheter heart valves (BE-THVs and SE-THVs, respectively) may influence the outcomes of transcatheter aortic valve replacement for bicuspid aortic valve (BAV) stenosis.
54. Performance of Creatinine and Cystatin C-Based Equations to Estimate Glomerular Filtration Rate Among Patients With Heart Failure.
作者: John Roth.;John C Lieske.;Sandra M Herrmann.;A M Arruda-Olson.;Joerg Herrmann.;Wendy McCallum.;Timothy S Larson.;Andrew D Rule.;Silvia M Titan.
来源: Circ Heart Fail. 2025年e013014页
The performance of estimated glomerular filtration rate (eGFR) among patients with heart failure (HF) may be worse than in the general population due to a higher prevalence of confounding factors affecting creatinine and cystatin C. Studies in this area are scarce and not stratified by type of HF. We evaluated the performance of current creatinine and cystatin C equations (eGFR creatinine-based equation [eGFRcr], eGFR serum cystatin C-based, and eGFR creatinine-cystatin C equation) compared with measured GFR (mGFR) among patients with HF stratified by ejection fraction.
55. Procedural and Clinical Outcomes After Orbital Atherectomy Versus Intravascular Lithotripsy in Patients With Calcified Nodules.
作者: Ali H Dakroub.;Doosup Shin.;Mandeep Singh.;Sarah Malik.;Rick H J A Volleberg.;Jonathan Weber.;Yasemin Ciftcikal.;Alysse Fazal.;Koshiro Sakai.;Takao Sato.;Akiko Maehara.;Mitsuaki Matsumura.;Jeffrey W Moses.;Gary S Mintz.;Omar Khalique.;Fernando Sosa.;Evan Shlofmitz.;Allen Jeremias.;Richard A Shlofmitz.;Ziad A Ali.
来源: Circ Cardiovasc Interv. 2025年e015254页
Calcified nodules (CNs) remain a major challenge in percutaneous coronary intervention (PCI). We sought to compare procedural and clinical outcomes after orbital atherectomy (OA) versus intravascular lithotripsy (IVL)-facilitated PCI in patients with CNs.
56. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
作者: Daniel W Jones.;Keith C Ferdinand.;Sandra J Taler.;Heather M Johnson.;Daichi Shimbo.;Marwah Abdalla.;M Martine Altieri.;Nisha Bansal.;Natalie A Bello.;Adam P Bress.;Jocelyn Carter.;Jordana B Cohen.;Karen J Collins.;Yvonne Commodore-Mensah.;Leslie L Davis.;Brent Egan.;Sadiya S Khan.;Donald M Lloyd-Jones.;Bernadette Mazurek Melnyk.;Eva A Mistry.;Modele O Ogunniyi.;Stacey L Schott.;Sidney C Smith.;Amy W Talbot.;Wanpen Vongpatanasin.;Karol E Watson.;Paul K Whelton.;Jeff D Williamson.
来源: Circulation. 2025年
The "2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults" retires and replaces the "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults."
58. Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy.
作者: Zhen Guo.;Anahita Ataran.;Pan Ma.;Wenjing Yu.;Hamidreza Hajirezaei.;Carla Valenzuela Ripoll.;Lauren Pedersen.;Omid Rashidi.;Mandy M Chan.;Mengcheng Shen.;Shannon Kelley.;Alireza Sargazi.;Mualla Ozcan.;Aynaz Lotfinaghsh.;Yoonje Cho.;Ahmed Diab.;Felicia Grogan.;Amanda Klaas.;Alexander Pompian.;Adnan Imam.;Rehman Lodhi.;Amen Bekele Zelleke.;Attila Kovacs.;Kenneth B Margulies.;Jeff Szymanski.;Marco Sardiello.;Babak Razani.;Aarti Asnani.;Benjamin Kopecky.;Pierre E Signore.;B Alexander Yi.;Craig T Basson.;Kodi S Ravichandran.;Sumanth D Prabhu.;Carmen Bergom.;Joel D Schilling.;Kory J Lavine.;Ali Javaheri.
来源: Circulation. 2025年
Doxorubicin cardiomyopathy (DoxCM) remains a significant clinical problem, but its underlying mechanisms remain incompletely understood. Identifying DoxCM mechanisms can lead to therapeutic interventions that improve patient outcomes.
59. TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.
作者: Mason E Sweat.;Wei Shi.;Yan Y Sweat.;Jie Li.;Jiajin Li.;Erin M Keating.;Anna Ponek.;Qing Ma.;Chaehyoung Park.;Michael A Trembley.;Yi Wang.;Cuilan Hou.;Vassilios J Bezzerides.;Frank L Conlon.;William T Pu.
来源: Circulation. 2025年
Atrial fibrillation, the most common sustained arrhythmia, affects 59 million individuals worldwide. The transcription factor TBX5 (T-box 5) is essential for normal atrial rhythm. Its inactivation causes loss of atrial cardiomyocyte (aCM) enhancer accessibility, looping, transcriptional identity, and spontaneous atrial fibrillation. TBX5 interacts with CHD4 (chromodomain helicase DNA-binding protein 4), a chromatin remodeling ATPase canonically associated with the NuRD (nucleosome remodeling and deacetylase) repressor complex.
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