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4803. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial.
作者: Javier Delgado-Lista.;Juan F Alcala-Diaz.;Jose D Torres-Peña.;Gracia M Quintana-Navarro.;Francisco Fuentes.;Antonio Garcia-Rios.;Ana M Ortiz-Morales.;Ana I Gonzalez-Requero.;Ana I Perez-Caballero.;Elena M Yubero-Serrano.;Oriol A Rangel-Zuñiga.;Antonio Camargo.;Fernando Rodriguez-Cantalejo.;Fernando Lopez-Segura.;Lina Badimon.;Jose M Ordovas.;Francisco Perez-Jimenez.;Pablo Perez-Martinez.;Jose Lopez-Miranda.; .
来源: Lancet. 2022年399卷10338期1876-1885页
Mediterranean and low-fat diets are effective in the primary prevention of cardiovascular disease. We did a long-term randomised trial to compare the effects of these two diets in secondary prevention of cardiovascular disease.
4805. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued for futility but randomisation to remdesivir continued. Here, we report the final results of Solidarity and meta-analyses of mortality in all relevant trials to date.
4806. Suicide and self-harm.
作者: Duleeka Knipe.;Prianka Padmanathan.;Giles Newton-Howes.;Lai Fong Chan.;Nav Kapur.
来源: Lancet. 2022年399卷10338期1903-1916页
Suicide and self-harm are major health and societal issues worldwide, but the greatest burden of both behaviours occurs in low-income and middle-income countries. Although rates of suicide are higher in male than in female individuals, self-harm is more common in female individuals. Rather than having a single cause, suicide and self-harm are the result of a complex interplay of several factors that occur throughout the life course, and vary by gender, age, ethnicity, and geography. Several clinical and public health interventions show promise, although our understanding of their effectiveness has largely originated from high-income countries. Attempting to predict suicide is unlikely to be helpful. Intervention and prevention must include both a clinical and community focus, and every health professional has a crucial part to play.
4808. A village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial.
作者: Yingxian Sun.;Jianjun Mu.;Dao Wen Wang.;Nanxiang Ouyang.;Liying Xing.;Xiaofan Guo.;Chunxia Zhao.;Guocheng Ren.;Ning Ye.;Ying Zhou.;Jun Wang.;Zhao Li.;Guozhe Sun.;Ruihai Yang.;Chung-Shiuan Chen.;Jiang He.; .
来源: Lancet. 2022年399卷10339期1964-1975页
The prevalence of uncontrolled hypertension is high and increasing in low-income and middle-income countries. We tested the effectiveness of a multifaceted intervention for blood pressure control in rural China led by village doctors (community health workers on the front line of primary health care).
4809. Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial.
作者: F Jasmijn Smits.;Anne Claire Henry.;Marc G Besselink.;Olivier R Busch.;Casper H van Eijck.;Mark Arntz.;Thomas L Bollen.;Otto M van Delden.;Daniel van den Heuvel.;Christiaan van der Leij.;Krijn P van Lienden.;Adriaan Moelker.;Bert A Bonsing.;Inne H Borel Rinkes.;Koop Bosscha.;Ronald M van Dam.;Wouter J M Derksen.;Marcel den Dulk.;Sebastiaan Festen.;Bas Groot Koerkamp.;Robbert J de Haas.;Jeroen Hagendoorn.;Erwin van der Harst.;Ignace H de Hingh.;Geert Kazemier.;Marion van der Kolk.;Mike Liem.;Daan J Lips.;Misha D Luyer.;Vincent E de Meijer.;J Sven Mieog.;Vincent B Nieuwenhuijs.;Gijs A Patijn.;Wouter W Te Riele.;Daphne Roos.;Jennifer M Schreinemakers.;Martijn W J Stommel.;Fennie Wit.;Babs A Zonderhuis.;Lois A Daamen.;C Henri van Werkhoven.;I Quintus Molenaar.;Hjalmar C van Santvoort.; .
来源: Lancet. 2022年399卷10338期1867-1875页
Early recognition and management of postoperative complications, before they become clinically relevant, can improve postoperative outcomes for patients, especially for high-risk procedures such as pancreatic resection.
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