4804. EDP-938, a Respiratory Syncytial Virus Inhibitor, in a Human Virus Challenge.
作者: Alaa Ahmad.;Kingsley Eze.;Nicolas Noulin.;Veronika Horvathova.;Bryan Murray.;Mark Baillet.;Laura Grey.;Julie Mori.;Nathalie Adda.
来源: N Engl J Med. 2022年386卷7期655-666页
Respiratory syncytial virus (RSV) infection causes substantial morbidity and mortality among infants, older adults, and immunocompromised adults. EDP-938, a nonfusion replication inhibitor of RSV, acts by modulating the viral nucleoprotein.
4806. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
作者: Jennifer Hammond.;Heidi Leister-Tebbe.;Annie Gardner.;Paula Abreu.;Weihang Bao.;Wayne Wisemandle.;MaryLynn Baniecki.;Victoria M Hendrick.;Bharat Damle.;Abraham Simón-Campos.;Rienk Pypstra.;James M Rusnak.; .
来源: N Engl J Med. 2022年386卷15期1397-1408页
Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (Mpro) inhibitor with potent pan-human-coronavirus activity in vitro.
4809. Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection.
作者: Victoria Hall.;Sarah Foulkes.;Ferdinando Insalata.;Peter Kirwan.;Ayoub Saei.;Ana Atti.;Edgar Wellington.;Jameel Khawam.;Katie Munro.;Michelle Cole.;Caio Tranquillini.;Andrew Taylor-Kerr.;Nipunadi Hettiarachchi.;Davina Calbraith.;Noshin Sajedi.;Iain Milligan.;Yrene Themistocleous.;Diane Corrigan.;Lisa Cromey.;Lesley Price.;Sally Stewart.;Elen de Lacy.;Chris Norman.;Ezra Linley.;Ashley D Otter.;Amanda Semper.;Jacqueline Hewson.;Silvia D'Arcangelo.;Meera Chand.;Colin S Brown.;Tim Brooks.;Jasmin Islam.;Andre Charlett.;Susan Hopkins.; .
来源: N Engl J Med. 2022年386卷13期1207-1220页
The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccine boosters.
4820. Five-Year Outcomes of the Partial Oral Treatment of Endocarditis (POET) Trial.
作者: Mia M Pries-Heje.;Christoffer Wiingaard.;Nikolaj Ihlemann.;Sabine U Gill.;Niels E Bruun.;Hanne Elming.;Jonas A Povlsen.;Trine Madsen.;Kaare T Jensen.;Kurt Fursted.;Martin Schultz.;Lauge Østergaard.;Jens J Christensen.;Ulrik Christiansen.;Flemming Rosenvinge.;Jannik Helweg-Larsen.;Emil L Fosbøl.;Lars Køber.;Christian Torp-Pedersen.;Niels Tønder.;Claus Moser.;Kasper Iversen.;Henning Bundgaard.
来源: N Engl J Med. 2022年386卷6期601-602页 |