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4661. Integrating Exercise Into Personalized Ventricular Arrhythmia Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy.
作者: Laurens P Bosman.;Weijia Wang.;Øyvind H Lie.;Freyja H M van Lint.;Christine Rootwelt-Norberg.;Brittney Murray.;Crystal Tichnell.;Julia Cadrin-Tourigny.;J Peter van Tintelen.;Folkert W Asselbergs.;Hugh Calkins.;Anneline S J M Te Riele.;Kristina H Haugaa.;Cynthia A James.
来源: Circ Arrhythm Electrophysiol. 2022年15卷2期e010221页
Exercise is associated with sustained ventricular arrhythmias (VA) in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) but is not included in the ARVC risk calculator (arvcrisk.com). The objective of this study is to quantify the influence of exercise at diagnosis on incident VA risk and evaluate whether the risk calculator needs adjustment for exercise.
4662. Clinical Presentation and Heart Failure in Children With Arrhythmogenic Cardiomyopathy.
作者: Elodie Surget.;Alice Maltret.;Francesca Raimondi.;Veronique Fressart.;Damien Bonnet.;Estelle Gandjbakhch.;Diala Khraiche.
来源: Circ Arrhythm Electrophysiol. 2022年15卷2期e010346页 4663. Pattern of Atrial Fibrillation and Cognitive Function in Young Patients With Atrial Fibrillation and Low CHADS2 Score: Insights From the BRAIN-AF Trial.
作者: Tudor Vrinceanu.;Paul Khairy.;Denis Roy.;Marie Payer.;Christine Gagnon.;Navin Kaushal.;Mario Talajic.;Jean-Claude Tardif.;Stanley Nattel.;Sandra E Black.;Jeffrey Healey.;Sylvain Lanthier.;Jason Andrade.;Fadi Massoud.;Isabelle Nault.;Marie-Claude Guertin.;Paul Dorian.;Simon Kouz.;Vidal Essebag.;Kenneth A Ellenbogen.;Normand Racine.;Anna Nozza.;Louis Bherer.;Léna Rivard.
来源: Circ Arrhythm Electrophysiol. 2022年15卷2期e010462页 4664. Longitudinal Invasive Hemodynamic Assessment in Patients With Acute Decompensated Heart Failure-Related Cardiogenic Shock: A Single-Center Experience.
作者: Luca Baldetti.;Stefania Sacchi.;Vittorio Pazzanese.;Francesco Calvo.;Mario Gramegna.;Giuseppe Barone.;Antonio Boccellino.;Matteo Pagnesi.;Alberto Maria Cappelletti.
来源: Circ Heart Fail. 2022年15卷2期e008976页 4666. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.
作者: Connie W Tsao.;Aaron W Aday.;Zaid I Almarzooq.;Alvaro Alonso.;Andrea Z Beaton.;Marcio S Bittencourt.;Amelia K Boehme.;Alfred E Buxton.;April P Carson.;Yvonne Commodore-Mensah.;Mitchell S V Elkind.;Kelly R Evenson.;Chete Eze-Nliam.;Jane F Ferguson.;Giuliano Generoso.;Jennifer E Ho.;Rizwan Kalani.;Sadiya S Khan.;Brett M Kissela.;Kristen L Knutson.;Deborah A Levine.;Tené T Lewis.;Junxiu Liu.;Matthew Shane Loop.;Jun Ma.;Michael E Mussolino.;Sankar D Navaneethan.;Amanda Marma Perak.;Remy Poudel.;Mary Rezk-Hanna.;Gregory A Roth.;Emily B Schroeder.;Svati H Shah.;Evan L Thacker.;Lisa B VanWagner.;Salim S Virani.;Jenifer H Voecks.;Nae-Yuh Wang.;Kristine Yaffe.;Seth S Martin.
来源: Circulation. 2022年145卷8期e153-e639页
The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).
4667. Trends in Characteristics and Outcomes in Primary Heart Failure Hospitalizations Among Older Population in the United States, 2004 to 2018.
作者: Abdul Mannan Khan Minhas.;Sardar Hassan Ijaz.;Shakeel Jamal.;Sourbha S Dani.;Muhammad Shahzeb Khan.;Stephen J Greene.;Marat Fudim.;Haider J Warraich.;Michael D Shapiro.;Salim S Virani.;Khurram Nasir.;Safi U Khan.
来源: Circ Heart Fail. 2022年15卷5期e008943页
Heart failure (HF) accounts for a significant proportion of morbidity, mortality, and health care costs among older adults in the United States. We evaluated trends in clinical outcomes and the economic burden of HF hospitalizations in older patients (≥80 years).
4669. Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart.
作者: Liang Chen.;Kui Hua.;Ningning Zhang.;Jingyu Wang.;Jian Meng.;Zhenliang Hu.;Haoxiang Gao.;Fanhong Li.;Yang Chen.;Jie Ren.;Liyang Liu.;Qiming Zhou.;Jin Gu.;Jiangping Song.;Xuegong Zhang.;Shengshou Hu.
来源: Circulation. 2022年145卷4期315-318页 4675. 2022 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration With the American Academy of Pediatrics, American Association for Respiratory Care, the Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists.
作者: Dianne L Atkins.;Comilla Sasson.;Antony Hsu.;Khalid Aziz.;Lance B Becker.;Robert A Berg.;Farhan Bhanji.;Steven M Bradley.;Steven C Brooks.;Melissa Chan.;Paul S Chan.;Adam Cheng.;Brian M Clemency.;Allan de Caen.;Jonathan P Duff.;Dana P Edelson.;Gustavo E Flores.;Susan Fuchs.;Saket Girotra.;Carl Hinkson.;Benny L Joyner.;Beena D Kamath-Rayne.;Monica Kleinman.;Peter J Kudenchuk.;Javier J Lasa.;Eric J Lavonas.;Henry C Lee.;Rebecca E Lehotzky.;Arielle Levy.;Mary E McBride.;Garth Meckler.;Raina M Merchant.;Vivek K Moitra.;Vinay Nadkarni.;Ashish R Panchal.;Mary Ann Peberdy.;Tia Raymond.;Kathryn Roberts.;Michael R Sayre.;Stephen M Schexnayder.;Robert M Sutton.;Mark Terry.;Alexis Topjian.;Brian Walsh.;David S Wang.;Carolyn M Zelop.;Ryan W Morgan.; .
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷4期e008900页 4678. Autologous CD34+ Stem Cell Therapy Increases Coronary Flow Reserve and Reduces Angina in Patients With Coronary Microvascular Dysfunction.
作者: Timothy D Henry.;C Noel Bairey Merz.;Janet Wei.;Michel T Corban.;Odayme Quesada.;Sandy Joung.;Christine L Kotynski.;Jian Wang.;Michelle Lewis.;Ann M Schumacher.;Ronnda L Bartel.;Hiroshi Takagi.;Vishal Shah.;Anna Lee.;William K Sietsema.;Douglas W Losordo.;Amir Lerman.
来源: Circ Cardiovasc Interv. 2022年15卷2期e010802页
Coronary microvascular dysfunction results in angina and adverse outcomes in patients with evidence of ischemia and nonobstructive coronary artery disease; however, no specific therapy exists. CD34+ cell therapy increases microvasculature in preclinical models and improves symptoms, exercise tolerance, and mortality in refractory angina patients with obstructive coronary artery disease. The objective of this research was to evaluate the safety, tolerability, and efficacy of intracoronary CD34+ cell therapy in patients with coronary microvascular dysfunction.
4679. Sex Differences in Health Status and Clinical Outcomes After Nonprimary Percutaneous Coronary Intervention.
作者: Pranoti G Hiremath.;Thomas Aversano.;John A Spertus.;Cynthia C Lemmon.;Daniel Q Naiman.;Matthew J Czarny.
来源: Circ Cardiovasc Interv. 2022年15卷2期e011308页
Greater insight into sex-based differences in health status can lay the foundation for more equitable health care. This study compares differences in health status of women and men in the CPORT-E trial (Cardiovascular Patient Outcomes Research Team Non-Primary Percutaneous Coronary Intervention) undergoing nonprimary percutaneous coronary intervention.
4680. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
作者: Riham R E Abouleisa.;Abou Bakr M Salama.;Qinghui Ou.;Xian-Liang Tang.;Mitesh Solanki.;Yiru Guo.;Yibing Nong.;Lindsey McNally.;Pawel K Lorkiewicz.;Kamal M Kassem.;Brooke M Ahern.;Krishna Choudhary.;Reuben Thomas.;Yu Huang.;Hamzah R Juhardeen.;Aisha Siddique.;Zainab Ifthikar.;Sally K Hammad.;Ayman S Elbaz.;Kathryn N Ivey.;Daniel J Conklin.;Jonathan Satin.;Bradford G Hill.;Deepak Srivastava.;Roberto Bolli.;Tamer M A Mohamed.
来源: Circulation. 2022年145卷17期1339-1355页
The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinase 4], CCNB [cyclin B1], and CCND [cyclin D1]) promotes cardiomyocyte proliferation in 15% to 20% of infected cardiomyocytes in vitro and in vivo and improves cardiac function after myocardial infarction in mice.
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