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4621. Pulse Oximetry for Monitoring Patients with Covid-19 at Home - A Pragmatic, Randomized Trial.
作者: Kathleen C Lee.;Anna U Morgan.;Krisda H Chaiyachati.;David A Asch.;Ruiying A Xiong.;David Do.;Austin S Kilaru.;Doreen Lam.;Andrew Parambath.;Ari B Friedman.;Zachary F Meisel.;Christopher K Snider.;Deena L Chisholm.;Sheila Kelly.;Jessica E Hemmons.;Dina Abdel-Rahman.;Jeffrey Ebert.;Medha Ghosh.;Julianne Reilly.;Christina J O'Malley.;Lauren Hahn.;Nancy M Mannion.;Ann M Huffenberger.;Susan McGinley.;Mohan Balachandran.;Neda Khan.;Judy A Shea.;Nandita Mitra.;M Kit Delgado.
来源: N Engl J Med. 2022年386卷19期1857-1859页 4622. Protection by a Fourth Dose of BNT162b2 against Omicron in Israel.
作者: Yinon M Bar-On.;Yair Goldberg.;Micha Mandel.;Omri Bodenheimer.;Ofra Amir.;Laurence Freedman.;Sharon Alroy-Preis.;Nachman Ash.;Amit Huppert.;Ron Milo.
来源: N Engl J Med. 2022年386卷18期1712-1720页
On January 2, 2022, Israel began administering a fourth dose of BNT162b2 vaccine to persons 60 years of age or older. Data are needed regarding the effect of the fourth dose on rates of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and of severe coronavirus disease 2019 (Covid-19).
4624. Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events.
作者: David R Jacobs.;Jessica G Woo.;Alan R Sinaiko.;Stephen R Daniels.;Johanna Ikonen.;Markus Juonala.;Noora Kartiosuo.;Terho Lehtimäki.;Costan G Magnussen.;Jorma S A Viikari.;Nanhua Zhang.;Lydia A Bazzano.;Trudy L Burns.;Ronald J Prineas.;Julia Steinberger.;Elaine M Urbina.;Alison J Venn.;Olli T Raitakari.;Terence Dwyer.
来源: N Engl J Med. 2022年386卷20期1877-1888页
Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease, but links to clinical events are unclear.
4626. Treatment for Mild Chronic Hypertension during Pregnancy.
作者: Alan T Tita.;Jeff M Szychowski.;Kim Boggess.;Lorraine Dugoff.;Baha Sibai.;Kirsten Lawrence.;Brenna L Hughes.;Joseph Bell.;Kjersti Aagaard.;Rodney K Edwards.;Kelly Gibson.;David M Haas.;Lauren Plante.;Torri Metz.;Brian Casey.;Sean Esplin.;Sherri Longo.;Matthew Hoffman.;George R Saade.;Kara K Hoppe.;Janelle Foroutan.;Methodius Tuuli.;Michelle Y Owens.;Hyagriv N Simhan.;Heather Frey.;Todd Rosen.;Anna Palatnik.;Susan Baker.;Phyllis August.;Uma M Reddy.;Wendy Kinzler.;Emily Su.;Iris Krishna.;Nicki Nguyen.;Mary E Norton.;Daniel Skupski.;Yasser Y El-Sayed.;Dotum Ogunyemi.;Zorina S Galis.;Lorie Harper.;Namasivayam Ambalavanan.;Nancy L Geller.;Suzanne Oparil.;Gary R Cutter.;William W Andrews.; .
来源: N Engl J Med. 2022年386卷19期1781-1792页
The benefits and safety of the treatment of mild chronic hypertension (blood pressure, <160/100 mm Hg) during pregnancy are uncertain. Data are needed on whether a strategy of targeting a blood pressure of less than 140/90 mm Hg reduces the incidence of adverse pregnancy outcomes without compromising fetal growth.
4628. Tranexamic Acid in Patients Undergoing Noncardiac Surgery.
作者: P J Devereaux.;Maura Marcucci.;Thomas W Painter.;David Conen.;Vladimir Lomivorotov.;Daniel I Sessler.;Matthew T V Chan.;Flavia K Borges.;María J Martínez-Zapata.;Chew Yin Wang.;Denis Xavier.;Sandra N Ofori.;Michael K Wang.;Sergey Efremov.;Giovanni Landoni.;Ydo V Kleinlugtenbelt.;Wojciech Szczeklik.;Denis Schmartz.;Amit X Garg.;Timothy G Short.;Maria Wittmann.;Christian S Meyhoff.;Mohammed Amir.;David Torres.;Ameen Patel.;Emmanuelle Duceppe.;Kurt Ruetzler.;Joel L Parlow.;Vikas Tandon.;Edith Fleischmann.;Carisi A Polanczyk.;Andre Lamy.;Sergey V Astrakov.;Mangala Rao.;William K K Wu.;Keyur Bhatt.;Miriam de Nadal.;Valery V Likhvantsev.;Pilar Paniagua.;Hector J Aguado.;Richard P Whitlock.;Michael H McGillion.;Michael Prystajecky.;Jessica Vincent.;John Eikelboom.;Ingrid Copland.;Kumar Balasubramanian.;Alparslan Turan.;Shrikant I Bangdiwala.;David Stillo.;Peter L Gross.;Teresa Cafaro.;Pascal Alfonsi.;Pavel S Roshanov.;Emilie P Belley-Côté.;Jessica Spence.;Toby Richards.;Tomas VanHelder.;William McIntyre.;Gordon Guyatt.;Salim Yusuf.;Kate Leslie.; .
来源: N Engl J Med. 2022年386卷21期1986-1997页
Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding.
4631. Effect of Early Treatment with Ivermectin among Patients with Covid-19.
作者: Gilmar Reis.;Eduardo A S M Silva.;Daniela C M Silva.;Lehana Thabane.;Aline C Milagres.;Thiago S Ferreira.;Castilho V Q Dos Santos.;Vitoria H S Campos.;Ana M R Nogueira.;Ana P F G de Almeida.;Eduardo D Callegari.;Adhemar D F Neto.;Leonardo C M Savassi.;Maria I C Simplicio.;Luciene B Ribeiro.;Rosemary Oliveira.;Ofir Harari.;Jamie I Forrest.;Hinda Ruton.;Sheila Sprague.;Paula McKay.;Christina M Guo.;Karen Rowland-Yeo.;Gordon H Guyatt.;David R Boulware.;Craig R Rayner.;Edward J Mills.; .
来源: N Engl J Med. 2022年386卷18期1721-1731页
The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.
4634. BNT162b2 Protection against the Omicron Variant in Children and Adolescents.
作者: Ashley M Price.;Samantha M Olson.;Margaret M Newhams.;Natasha B Halasa.;Julie A Boom.;Leila C Sahni.;Pia S Pannaraj.;Katherine Irby.;Katherine E Bline.;Aline B Maddux.;Ryan A Nofziger.;Melissa A Cameron.;Tracie C Walker.;Stephanie P Schwartz.;Elizabeth H Mack.;Laura Smallcomb.;Jennifer E Schuster.;Charlotte V Hobbs.;Satoshi Kamidani.;Keiko M Tarquinio.;Tamara T Bradford.;Emily R Levy.;Kathleen Chiotos.;Samina S Bhumbra.;Natalie Z Cvijanovich.;Sabrina M Heidemann.;Melissa L Cullimore.;Shira J Gertz.;Bria M Coates.;Mary A Staat.;Matt S Zinter.;Michele Kong.;Brandon M Chatani.;Janet R Hume.;Katri V Typpo.;Mia Maamari.;Heidi R Flori.;Mark W Tenforde.;Laura D Zambrano.;Angela P Campbell.;Manish M Patel.;Adrienne G Randolph.; .
来源: N Engl J Med. 2022年386卷20期1899-1909页
Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for coronavirus disease 2019 (Covid-19), generated concern about immune evasion and the duration of protection from vaccines in children and adolescents.
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