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4602. One-Year Major Cardiovascular Events After Restrictive Versus Liberal Blood Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Trial.
作者: Jose R Gonzalez-Juanatey.;Gilles Lemesle.;Etienne Puymirat.;Gregory Ducrocq.;Marine Cachanado.;Joan Albert Arnaiz.;Manuel Martínez-Sellés.;Johanne Silvain.;Albert Ariza-Solé.;Emile Ferrari.;Gonzalo Calvo.;Nicolas Danchin.;Cristina Avendano-Solá.;Alexandra Rousseau.;Eric Vicaut.;Teba Gonzalez-Ferrero.;Philippe Gabriel Steg.;Tabassome Simon.; .
来源: Circulation. 2022年145卷6期486-488页 4604. Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort.
作者: Swati Tomar.;David C Klinzing.;Ching Kit Chen.;Louis Hanqiang Gan.;Tia Moscarello.;Chloe Reuter.;Euan A Ashley.;Roger Foo.
来源: Circ Genom Precis Med. 2022年15卷2期e003536页
Variable penetrance and late-onset phenotypes are key challenges for classifying causal as well as incidental findings in inherited cardiac conditions. Allele frequencies of variants in ancestry-specific populations, along with clinical variant analysis and interpretation, are critical to determine their true significance.
4605. Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion.
作者: Sébastien Soubeyrand.;Paulina Lau.;Majid Nikpay.;Anh-Thu Dang.;Ruth McPherson.
来源: Circ Genom Precis Med. 2022年15卷2期e003428页
Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling that have been proposed to contribute to atherosclerosis. Moreover, recent large-scale genome-wide association studies (GWAS) have linked common genetic variants within the FN1 gene to coronary artery disease risk.
4606. How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior: an Observational Follow-up Study.
作者: Elisabeth Widén.;Nella Junna.;Sanni Ruotsalainen.;Ida Surakka.;Nina Mars.;Pietari Ripatti.;Juulia J Partanen.;Johanna Aro.;Pekka Mustonen.;Tiinamaija Tuomi.;Aarno Palotie.;Veikko Salomaa.;Jaakko Kaprio.;Jukka Partanen.;Kristina Hotakainen.;Pasi Pöllänen.;Samuli Ripatti.
来源: Circ Genom Precis Med. 2022年15卷2期e003459页
Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear.
4607. Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity.
作者: Sarah U Morton.;Alexandre C Pereira.;Daniel Quiat.;Felix Richter.;Alexander Kitaygorodsky.;Jacob Hagen.;Daniel Bernstein.;Martina Brueckner.;Elizabeth Goldmuntz.;Richard W Kim.;Richard P Lifton.;George A Porter.;Martin Tristani-Firouzi.;Wendy K Chung.;Amy Roberts.;Bruce D Gelb.;Yufeng Shen.;Jane W Newburger.;J G Seidman.;Christine E Seidman.
来源: Circ Genom Precis Med. 2022年15卷2期e003500页
Congenital heart disease (CHD) is the most common anomaly at birth, with a prevalence of ≈1%. While infants born to mothers with diabetes or obesity have a 2- to 3-fold increased incidence of CHD, the cause of the increase is unknown. Damaging de novo variants (DNV) in coding regions are more common among patients with CHD, but genome-wide rates of coding and noncoding DNVs associated with these prenatal exposures have not been studied in patients with CHD.
4608. Monomorphic and Polymorphic Ventricular Arrhythmias in Heterozygous Calsequestrin-2 Mutation Carriers.
作者: Juan Jiménez-Jáimez.;Mercedes Cabrera Ramos.;Francisco Bermúdez-Jiménez.;José Manuel García Pinilla.;Ainhoa Robles Mezcua.;Rosa Macías Ruiz.;Miguel Álvarez.;Luis Tercedor.
来源: Circ Genom Precis Med. 2022年15卷2期e003518页 4609. End Stage Mitochondrial Cardiomyopathy and Heart Transplantation Due to Biallelic Pathogenic C1QBP Variants.
作者: Nicholas S Wilcox.;Stuart B Prenner.;Marisa Cevasco.;Courtney Condit.;Amy Goldstein.;James T Peterson.;Isabella Tondi Resta.;Matthew Palmer.;Priti Lal.;Anjali Tiku Owens.;Janice Pieretti.;Theodore G Drivas.;Nosheen Reza.
来源: Circ Genom Precis Med. 2022年15卷2期e003559页 4610. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth.
作者: Haobo Li.;Lena E Trager.;Xiaojun Liu.;Margaret H Hastings.;Chunyang Xiao.;Justin Guerra.;Samantha To.;Guoping Li.;Ashish Yeri.;Rodosthenis Rodosthenous.;Michael G Silverman.;Saumya Das.;Amrut V Ambardekar.;Michael R Bristow.;Juan Manuel González-Rosa.;Anthony Rosenzweig.
来源: Circulation. 2022年145卷16期1218-1233页
The heart grows in response to pathological and physiological stimuli. The former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects the heart and enhances cardiomyogenesis. The mechanisms underlying these differences remain incompletely understood. Although long noncoding RNAs (lncRNAs) are important in cardiac development and disease, less is known about their roles in physiological hypertrophy or cardiomyogenesis.
4611. Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction.
作者: Antoinette F van Ouwerkerk.;Fernanda M Bosada.;Karel van Duijvenboden.;Arjan C Houweling.;Koen T Scholman.;Vincent Wakker.;Cornelis P Allaart.;Jae-Sun Uhm.;Inge B Mathijssen.;Ton Baartscheer.;Alex V Postma.;Phil Barnett.;Arie O Verkerk.;Bastiaan J Boukens.;Vincent M Christoffels.
来源: Circulation. 2022年145卷8期606-619页
The pathogenic missense variant p.G125R in TBX5 (T-box transcription factor 5) causes Holt-Oram syndrome (also known as hand-heart syndrome) and early onset of atrial fibrillation. Revealing how an altered key developmental transcription factor modulates cardiac physiology in vivo will provide unique insights into the mechanisms underlying atrial fibrillation in these patients.
4612. CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.
作者: Guoshuai Feng.;Geetika Bajpai.;Pan Ma.;Andrew Koenig.;Andrea Bredemeyer.;Inessa Lokshina.;Lulu Lai.;Irmgard Förster.;Florian Leuschner.;Daniel Kreisel.;Kory J Lavine.
来源: Circulation. 2022年145卷10期765-782页
Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that contribute to adverse left ventricle (LV) remodeling and heart failure progression. Elucidation of the effector mechanisms that mediate adverse effects of CCR2+ monocytes, macrophages, and dendritic cells will yield important insights into therapeutic strategies to suppress myocardial inflammation.
4614. Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome.
作者: Belinda Gray.;Alban-Elouen Baruteau.;Albert A Antolin.;Alan Pittman.;Giselle Sarganas.;Mariam Molokhia.;Marieke T Blom.;Rachel Bastiaenen.;Abdenasser Bardai.;Silvia G Priori.;Carlo Napolitano.;Peter E Weeke.;Saad A Shakir.;Wilhelm Haverkamp.;Jordi Mestres.;Bo Gregers Winkel.;Adam A Witney.;Irina Chis-Ster.;Ajanthah Sangaralingam.;A John Camm.;Jacob Tfelt-Hansen.;Dan M Roden.;Hanno L Tan.;Edeltraut Garbe.;Miriam Sturkenboom.;Elijah R Behr.
来源: Circ Genom Precis Med. 2022年15卷1期e003391页
Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk.
4615. Efficacy and Safety of Chinese Herbal Medicine Compared With Losartan for Mild Essential Hypertension: A Randomized, Multicenter, Double-Blind, Noninferiority Trial.
作者: Xinxing Lai.;Zhenyu Dong.;Shengxian Wu.;Xiaohua Zhou.;Genming Zhang.;Shangquan Xiong.;Wei Wu.;Rui Cao.;Xiaolong Wang.;Qi Hua.;Jinhang Du.;Jinying Fan.;Jingyuan Mao.;Weimin Jiang.;Huishu Yuan.;Yushan Chen.;Yong Xu.;Zhanquan Li.;Jun Zhang.;Guiying Dong.;Hui Zhen.;Ru Ding.;Zonggui Wu.;Ying Gao.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷3期e007923页
Hypertension is one of the most challenging public health problems worldwide. Previous studies suggested that the Songling Xuemaikang capsule (SXC)-a Chinese herbal formula-was effective for essential hypertension. However, the efficacy of SXC monotherapy for hypertension remains unclear. We aimed to compare the blood pressure (BP)-lowering efficacy and safety of SXC versus losartan in patients with essential hypertension.
4616. Cost-Effectiveness of Antibiotic-Eluting Envelope for Prevention of Cardiac Implantable Electronic Device Infections in Heart Failure.
作者: Ronuk M Modi.;Chia-Liang Liu.;Nicolas Isaza.;Inbar Raber.;Paola Calvachi.;Peter Zimetbaum.;Brandon K Bellows.;Daniel B Kramer.;Dhruv S Kazi.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷3期e008443页
Use of an antibiotic-eluting envelope (AEE) during cardiac implantable electronic device procedures reduces infection risk but increases procedural costs. We aim to estimate the cost-effectiveness of AEE use during cardiac implantable electronic device procedures among patients with heart failure.
4619. Exposure to Neighborhood-Level Racial Residential Segregation in Young Adulthood to Midlife and Incident Subclinical Atherosclerosis in Black Adults: The Coronary Artery Risk Development in Young Adults Study.
作者: Naveen M Reddy.;Stephanie L Mayne.;Lindsay R Pool.;Penny Gordon-Larsen.;John Jeffrey Carr.;James G Terry.;Kiarri N Kershaw.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷2期e007986页
Neighborhood-level racial residential segregation has been linked to several cardiovascular disease risk factors and outcomes in Black adults, but its impact on subclinical atherosclerosis remains unknown. In addition, although the impact of segregation on health may vary over the life course, most studies have examined segregation exposure at a single point in time. This article takes a life course approach by examining associations of exposure to neighborhood-level racial residential segregation in young adulthood and patterns of exposure from young adulthood to midlife with coronary artery calcification (CAC) incidence.
4620. Changes in Emergency Department Arrival Times for Acute Myocardial Infarction During the COVID-19 Pandemic Suggest Delays in Care Seeking.
作者: Alexander T Janke.;Cameron J Gettel.;Adrian Haimovich.;Keith E Kocher.;Harlan M Krumholz.;Arjun K Venkatesh.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷2期e008402页 |