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4606. Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer.
作者: Peter Schmid.;Javier Cortes.;Rebecca Dent.;Lajos Pusztai.;Heather McArthur.;Sherko Kümmel.;Jonas Bergh.;Carsten Denkert.;Yeon Hee Park.;Rina Hui.;Nadia Harbeck.;Masato Takahashi.;Michael Untch.;Peter A Fasching.;Fatima Cardoso.;Jay Andersen.;Debra Patt.;Michael Danso.;Marta Ferreira.;Marie-Ange Mouret-Reynier.;Seock-Ah Im.;Jin-Hee Ahn.;Maria Gion.;Sally Baron-Hay.;Jean-François Boileau.;Yu Ding.;Konstantinos Tryfonidis.;Gursel Aktan.;Vassiliki Karantza.;Joyce O'Shaughnessy.; .
来源: N Engl J Med. 2022年386卷6期556-567页
The addition of pembrolizumab to neoadjuvant chemotherapy led to a significantly higher percentage of patients with early triple-negative breast cancer having a pathological complete response (defined as no invasive cancer in the breast and negative nodes) at definitive surgery in an earlier analysis of this phase 3 trial of neoadjuvant and adjuvant therapy. The primary results regarding event-free survival in this trial have not been reported.
4607. Survival with Cemiplimab in Recurrent Cervical Cancer.
作者: Krishnansu S Tewari.;Bradley J Monk.;Ignace Vergote.;Austin Miller.;Andreia C de Melo.;Hee-Seung Kim.;Yong Man Kim.;Alla Lisyanskaya.;Vanessa Samouëlian.;Domenica Lorusso.;Fernanda Damian.;Chih-Long Chang.;Evgeniy A Gotovkin.;Shunji Takahashi.;Daniella Ramone.;Joanna Pikiel.;Beata Maćkowiak-Matejczyk.;Eva M Guerra Alía.;Nicoletta Colombo.;Yulia Makarova.;Danny Rischin.;Stephanie Lheureux.;Kosei Hasegawa.;Keiichi Fujiwara.;Jingjin Li.;Shaheda Jamil.;Vladimir Jankovic.;Chieh-I Chen.;Frank Seebach.;David M Weinreich.;George D Yancopoulos.;Israel Lowy.;Melissa Mathias.;Matthew G Fury.;Ana Oaknin.; .
来源: N Engl J Med. 2022年386卷6期544-555页
Patients with recurrent cervical cancer have a poor prognosis. Cemiplimab, the fully human programmed cell death 1 (PD-1)-blocking antibody approved to treat lung and skin cancers, has been shown to have preliminary clinical activity in this population.
4608. Cemented or Uncemented Hemiarthroplasty for Intracapsular Hip Fracture.
作者: Miguel A Fernandez.;Juul Achten.;Nicholas Parsons.;Xavier L Griffin.;May-Ee Png.;Jenny Gould.;Alwin McGibbon.;Matthew L Costa.; .
来源: N Engl J Med. 2022年386卷6期521-530页
Controversy exists over the use of bone cement in hip fractures treated with hemiarthroplasty. Only limited data on quality of life after cemented as compared with modern uncemented hemiarthroplasties are available.
4609. Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S.
作者: Jerald Sadoff.;Glenda Gray.;An Vandebosch.;Vicky Cárdenas.;Georgi Shukarev.;Beatriz Grinsztejn.;Paul A Goepfert.;Carla Truyers.;Ilse Van Dromme.;Bart Spiessens.;Johan Vingerhoets.;Jerome Custers.;Gert Scheper.;Merlin L Robb.;John Treanor.;Martin F Ryser.;Dan H Barouch.;Edith Swann.;Mary A Marovich.;Kathleen M Neuzil.;Lawrence Corey.;Jeffrey Stoddard.;Karin Hardt.;Javier Ruiz-Guiñazú.;Mathieu Le Gars.;Hanneke Schuitemaker.;Johan Van Hoof.;Frank Struyf.;Macaya Douoguih.; .
来源: N Engl J Med. 2022年386卷9期847-860页
The Ad26.COV2.S vaccine was highly effective against severe-critical coronavirus disease 2019 (Covid-19), hospitalization, and death in the primary phase 3 efficacy analysis.
4611. Protection against the Omicron Variant from Previous SARS-CoV-2 Infection.
作者: Heba N Altarawneh.;Hiam Chemaitelly.;Mohammad R Hasan.;Houssein H Ayoub.;Suelen Qassim.;Sawsan AlMukdad.;Peter Coyle.;Hadi M Yassine.;Hebah A Al-Khatib.;Fatiha M Benslimane.;Zaina Al-Kanaani.;Einas Al-Kuwari.;Andrew Jeremijenko.;Anvar H Kaleeckal.;Ali N Latif.;Riyazuddin M Shaik.;Hanan F Abdul-Rahim.;Gheyath K Nasrallah.;Mohamed G Al-Kuwari.;Adeel A Butt.;Hamad E Al-Romaihi.;Mohamed H Al-Thani.;Abdullatif Al-Khal.;Roberto Bertollini.;Patrick Tang.;Laith J Abu-Raddad.
来源: N Engl J Med. 2022年386卷13期1288-1290页 4616. Endovascular Therapy for Acute Stroke with a Large Ischemic Region.
作者: Shinichi Yoshimura.;Nobuyuki Sakai.;Hiroshi Yamagami.;Kazutaka Uchida.;Mikiya Beppu.;Kazunori Toyoda.;Yuji Matsumaru.;Yasushi Matsumoto.;Kazumi Kimura.;Masataka Takeuchi.;Yukako Yazawa.;Naoto Kimura.;Keigo Shigeta.;Hirotoshi Imamura.;Ichiro Suzuki.;Yukiko Enomoto.;So Tokunaga.;Kenichi Morita.;Fumihiro Sakakibara.;Norito Kinjo.;Takuya Saito.;Reiichi Ishikura.;Manabu Inoue.;Takeshi Morimoto.
来源: N Engl J Med. 2022年386卷14期1303-1313页
Endovascular therapy for acute ischemic stroke is generally avoided when the infarction is large, but the effect of endovascular therapy with medical care as compared with medical care alone for large strokes has not been well studied.
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