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4542. Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
作者: Jin-Kai Wang.;Yang Li.;Xiao-Lu Zhao.;Yuan-Bin Liu.;Jing Tan.;Yu-Ying Xing.;Dilare Adi.;Yong-Tao Wang.;Zhen-Yan Fu.;Yi-Tong Ma.;Song-Mei Liu.;Yong Liu.;Yan Wang.;Xiong-Jie Shi.;Xiao-Yi Lu.;Bao-Liang Song.;Jie Luo.
来源: Circulation. 2022年145卷9期675-687页
High blood cholesterol accelerates the progression of atherosclerosis, which is an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces thrombosis, which results in myocardial infarction or stroke. Lowering cholesterol levels is beneficial for preventing atherosclerotic cardiovascular disease.
4543. Transcatheter Mitral Intervention Relieves Dynamic Outflow Obstruction and Reduces Cardiac Workload in Hypertrophic Cardiomyopathy.
作者: Carey Kimmelstiel.;Kay D Everett.;Pankaj Jain.;Satoshi Miyashita.;Richard Botto.;Charles Resor.;Ethan Rowin.;Martin Maron.;Navin K Kapur.
来源: Circ Heart Fail. 2022年15卷4期e009171页 4544. Peripheral Venous Pressure-Assisted Exercise Stress Echocardiography in the Evaluation of Pulmonary Hypertension During Exercise in Patients With Suspected Heart Failure With Preserved Ejection Fraction.
作者: Jeong Hoon Yang.;Tomonari Harada.;Ki Hong Choi.;Toshimitsu Kato.;Darae Kim.;Noriaki Takama.;Taek Kyu Park.;Masahiko Kurabayashi.;Sung-A Chang.;Masaru Obokata.
来源: Circ Heart Fail. 2022年15卷3期e009028页
Identification of elevated pulmonary artery (PA) pressures during exercise may provide diagnostic, prognostic, and therapeutic implications in heart failure with preserved ejection fraction. Although widely performed, exercise stress echocardiography may underestimate true PA pressures due to the difficulty in estimating right atrial pressure (RAP) during exercise. We hypothesized that peripheral venous pressure (PVP) could allow for reliable estimation of RAP, and thus PA pressures during exercise stress echocardiography.
4545. Strategies to Reduce Low-Value Cardiovascular Care: A Scientific Statement From the American Heart Association.
作者: Vinay Kini.;Khadijah Breathett.;Peter W Groeneveld.;P Michael Ho.;Brahmajee K Nallamothu.;Pamela N Peterson.;Pam Rush.;Tracy Y Wang.;Emily P Zeitler.;William B Borden.; .
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷3期e000105页
Low-value health care services that provide little or no benefit to patients are common, potentially harmful, and costly. Nearly half of the patients in the United States will receive at least 1 low-value test or procedure annually, creating risk of avoidable complications from subsequent cascades of care and excess costs to patients and society. Reducing low-value care is of particular importance to cardiovascular health given the high prevalence and costs of cardiovascular disease in the United States. This scientific statement describes the current scope and impact of low-value cardiovascular care; reviews existing literature on patient-, clinician-, health system-, payer-, and policy-level interventions to reduce low-value care; proposes solutions to achieve meaningful and equitable reductions in low-value care; and suggests areas for future research priorities.
4551. Response by Zhang and Ji to Letter Regarding Article, "HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression".4554. Letter by Wang et al Regarding Article, "HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression".4556. Long-Term Efficacy of Colchicine in Patients With Chronic Coronary Disease: Insights From LoDoCo2.
作者: Tjerk S J Opstal.;Amber van Broekhoven.;Aernoud T L Fiolet.;Arend Mosterd.;John W Eikelboom.;Stefan M Nidorf.;Peter L Thompson.;Charley A Budgeon.;Louis Bartels.;Ron de Nooijer.;Willem A Bax.;Jan G P Tijssen.;Saloua El Messaoudi.;Jan H Cornel.
来源: Circulation. 2022年145卷8期626-628页 4558. Anterior Mitral Leaflet Dissection and Pseudoaneurysm Late After Transcatheter Aortic Valve Replacement: Look Beyond the Obvious.
作者: David Del Val.;Beatriz López-Melgar.;Fernando Rivero.;Mariel Fabiola Valdivia-Mazeyra.;Teresa Bastante.;Javier Cuesta.;Pilar Roquero.;Fernando Alfonso.
来源: Circ Cardiovasc Imaging. 2022年15卷3期e013724页 4559. Blood Pressure Drops During Hospitalization for Acute Heart Failure Treated With Serelaxin: A Patient-Level Analysis of 4 Randomized Controlled Trials.
作者: Johannes Grand.;Kristina Miger.;Ahmad Sajadieh.;Lars Køber.;Christian Torp-Pedersen.;Georg Ertl.;José López-Sendón.;Aldo Pietro Maggioni.;John R Teerlink.;Naoki Sato.;Claudio Gimpelewicz.;Marco Metra.;Thomas Holbro.;Olav W Nielsen.
来源: Circ Heart Fail. 2022年15卷4期e009199页
Hypotensive events and drops in systolic blood pressure (SBP-drop) are frequent in patients hospitalized with acute heart failure. We investigated whether SBP-drops are associated with outcomes in patients treated with serelaxin.
4560. Hemodynamic Determinants of Left Atrial Strain in Symptomatic Patients With Significant Primary Mitral Regurgitation.
作者: Payam Pournazari.;Nadeen N Faza.;Sachin S Goel.;Momin U Islam.;Stephen H Little.;Sherif F Nagueh.
来源: Circ Cardiovasc Imaging. 2022年15卷3期e013836页 |