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4521. CT or Invasive Coronary Angiography in Stable Chest Pain.
作者: .;Pál Maurovich-Horvat.;Maria Bosserdt.;Klaus F Kofoed.;Nina Rieckmann.;Theodora Benedek.;Patrick Donnelly.;José Rodriguez-Palomares.;Andrejs Erglis.;Cyril Štěchovský.;Gintare Šakalyte.;Nada Čemerlić Adić.;Matthias Gutberlet.;Jonathan D Dodd.;Ignacio Diez.;Gershan Davis.;Elke Zimmermann.;Cezary Kępka.;Radosav Vidakovic.;Marco Francone.;Małgorzata Ilnicka-Suckiel.;Fabian Plank.;Juhani Knuuti.;Rita Faria.;Stephen Schröder.;Colin Berry.;Luca Saba.;Balazs Ruzsics.;Christine Kubiak.;Iñaki Gutierrez-Ibarluzea.;Kristian Schultz Hansen.;Jacqueline Müller-Nordhorn.;Bela Merkely.;Andreas D Knudsen.;Imre Benedek.;Clare Orr.;Filipa Xavier Valente.;Ligita Zvaigzne.;Vojtěch Suchánek.;Laura Zajančkauskiene.;Filip Adić.;Michael Woinke.;Mark Hensey.;Iñigo Lecumberri.;Erica Thwaite.;Michael Laule.;Mariusz Kruk.;Aleksandar N Neskovic.;Massimo Mancone.;Donata Kuśmierz.;Gudrun Feuchtner.;Mikko Pietilä.;Vasco Gama Ribeiro.;Tanja Drosch.;Christian Delles.;Gildo Matta.;Michael Fisher.;Bálint Szilveszter.;Linnea Larsen.;Mihaela Ratiu.;Stephanie Kelly.;Bruno Garcia Del Blanco.;Ainhoa Rubio.;Zsófia D Drobni.;Birgit Jurlander.;Ioana Rodean.;Susan Regan.;Hug Cuéllar Calabria.;Melinda Boussoussou.;Thomas Engstrøm.;Roxana Hodas.;Adriane E Napp.;Robert Haase.;Sarah Feger.;Lina M Serna-Higuita.;Konrad Neumann.;Henryk Dreger.;Matthias Rief.;Viktoria Wieske.;Melanie Estrella.;Peter Martus.;Marc Dewey.
来源: N Engl J Med. 2022年386卷17期1591-1602页
In the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive coronary angiography (ICA). However, the comparative effectiveness of CT and ICA in the management of CAD to reduce the frequency of major adverse cardiovascular events is uncertain.
4529. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity.
作者: Joseph Domachowske.;Shabir A Madhi.;Eric A F Simões.;Victoria Atanasova.;Fernando Cabañas.;Kenji Furuno.;Maria L Garcia-Garcia.;Ineta Grantina.;Kim A Nguyen.;Dennis Brooks.;Yue Chang.;Amanda Leach.;Therese Takas.;Yuan Yuan.;M Pamela Griffin.;Vaishali S Mankad.;Tonya Villafana.; .
来源: N Engl J Med. 2022年386卷9期892-894页 4535. Multistate Outbreak of Melioidosis Associated with Imported Aromatherapy Spray.
作者: Jay E Gee.;William A Bower.;Amber Kunkel.;Julia Petras.;Jenna Gettings.;Maria Bye.;Melanie Firestone.;Mindy G Elrod.;Lindy Liu.;David D Blaney.;Allison Zaldivar.;Chelsea Raybern.;Farah S Ahmed.;Heidi Honza.;Shelley Stonecipher.;Briana J O'Sullivan.;Ruth Lynfield.;Melissa Hunter.;Skyler Brennan.;Jessica Pavlick.;Julie Gabel.;Cherie Drenzek.;Rachel Geller.;Crystal Lee.;Jana M Ritter.;Sherif R Zaki.;Christopher A Gulvik.;W Wyatt Wilson.;Elizabeth Beshearse.;Bart J Currie.;Jessica R Webb.;Zachary P Weiner.;María E Negrón.;Alex R Hoffmaster.
来源: N Engl J Med. 2022年386卷9期861-868页
Melioidosis, caused by the bacterium Burkholderia pseudomallei, is an uncommon infection that is typically associated with exposure to soil and water in tropical and subtropical environments. It is rarely diagnosed in the continental United States. Patients with melioidosis in the United States commonly report travel to regions where melioidosis is endemic. We report a cluster of four non-travel-associated cases of melioidosis in Georgia, Kansas, Minnesota, and Texas. These cases were caused by the same strain of B. pseudomallei that was linked to an aromatherapy spray product imported from a melioidosis-endemic area.
4536. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants.
作者: Laura L Hammitt.;Ron Dagan.;Yuan Yuan.;Manuel Baca Cots.;Miroslava Bosheva.;Shabir A Madhi.;William J Muller.;Heather J Zar.;Dennis Brooks.;Amy Grenham.;Ulrika Wählby Hamrén.;Vaishali S Mankad.;Pin Ren.;Therese Takas.;Michael E Abram.;Amanda Leach.;M Pamela Griffin.;Tonya Villafana.; .
来源: N Engl J Med. 2022年386卷9期837-846页
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection and hospitalization in infants. Nirsevimab is a monoclonal antibody to the RSV fusion protein that has an extended half-life. The efficacy and safety of nirsevimab in healthy late-preterm and term infants are uncertain.
4537. High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality.
作者: P J Devereaux.;Andre Lamy.;Matthew T V Chan.;René V Allard.;Vladimir V Lomivorotov.;Giovanni Landoni.;Hong Zheng.;Domenico Paparella.;Michael H McGillion.;Emilie P Belley-Côté.;Joel L Parlow.;Malcolm J Underwood.;Chew Yin Wang.;Nazari Dvirnik.;Marat Abubakirov.;Evgeny Fominskiy.;Stephen Choi.;Stephen Fremes.;Fabrizio Monaco.;Gerard Urrútia.;Marialuz Maestre.;Ludhmila A Hajjar.;Graham S Hillis.;Nicholas L Mills.;Vito Margari.;Joseph D Mills.;J Stephen Billing.;Emily Methangkool.;Carisi A Polanczyk.;Roberto Sant'Anna.;Dmitry Shukevich.;David Conen.;Peter A Kavsak.;Matthew J McQueen.;Katheryn Brady.;Jessica Spence.;Yannick Le Manach.;Rajibul Mian.;Shun Fu Lee.;Shrikant I Bangdiwala.;Sara Hussain.;Flavia K Borges.;Shirley Pettit.;Jessica Vincent.;Gordon H Guyatt.;Salim Yusuf.;Joseph S Alpert.;Harvey D White.;Richard P Whitlock.; .
来源: N Engl J Med. 2022年386卷9期827-836页
Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations.
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