4535. CTLA-4 Blockade Resistance after Relatlimab and Nivolumab.
作者: Alexander M Menzies.;Ines Pires da Silva.;Claudia Trojaniello.;Elisabeth Vieu.;Rodabe N Amaria.;Lisa Zimmer.;Serigne N Lo.;Elizabeth M Burton.;Hussein A Tawbi.;Dirk Schadendorf.;Jean J Grob.;Paolo A Ascierto.;Georgina V Long.
来源: N Engl J Med. 2022年386卷17期1668-1669页 4539. Nasal High-Flow Therapy during Neonatal Endotracheal Intubation.
作者: Kate A Hodgson.;Louise S Owen.;C Omar F Kamlin.;Calum T Roberts.;Sophie E Newman.;Kate L Francis.;Susan M Donath.;Peter G Davis.;Brett J Manley.
来源: N Engl J Med. 2022年386卷17期1627-1637页
Neonatal endotracheal intubation often involves more than one attempt, and oxygen desaturation is common. It is unclear whether nasal high-flow therapy, which extends the time to desaturation during elective intubation in children and adults receiving general anesthesia, can improve the likelihood of successful neonatal intubation on the first attempt.
4540. Prefusion F Protein-Based Respiratory Syncytial Virus Immunization in Pregnancy.
作者: Eric A F Simões.;Kimberly J Center.;Alan T N Tita.;Kena A Swanson.;David Radley.;John Houghton.;Stephanie B McGrory.;Emily Gomme.;Marquita Anderson.;John P Roberts.;Daniel A Scott.;Kathrin U Jansen.;William C Gruber.;Philip R Dormitzer.;Alejandra C Gurtman.
来源: N Engl J Med. 2022年386卷17期1615-1626页
Respiratory syncytial virus (RSV), a major cause of illness and death in infants worldwide, could be prevented by vaccination during pregnancy. The efficacy, immunogenicity, and safety of a bivalent RSV prefusion F protein-based (RSVpreF) vaccine in pregnant women and their infants are uncertain.
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